Long-term prophylactic insulin treatment can prevent spontaneous diabetes and thyroiditis development in the diabetes-prone bio-breeding rat, while short-term treatment is ineffective

European Journal of Endocrinology

Volumn 149, Issue 3, 2003, Pages 223-229

  Visser, J ^a   Klatter, F ^a   Vis, L ^a   Groen, H ^a   Strubbe, J ^a   Rozing, J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; CELL FUNCTION; CLINICAL PROTOCOL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG PELLET; FEMALE; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; INSULITIS; LONG TERM CARE; MALE; NONHUMAN; ONSET AGE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SHORT COURSE THERAPY; THYROIDITIS;

ANIMALS; AUTOANTIBODIES; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUCOSE TOLERANCE TEST; HISTOCYTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MALE; PREDIABETIC STATE; RATS; RATS, INBRED BB; THYROIDITIS, AUTOIMMUNE;

EID: 0141627768     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1490223     Document Type: Article

References (27)

1. Mordes JP, Bortell R, Groen H, Guberski DL, Rossini AA & Greiner D. Autoimmune diabetes mellitus in the BB rat. In Animal Models for Autoimmune diseases, pp 1-41. Eds AAF Sima & E Shafrir. Amsterdam: Harwood Academic Publishers, 2001.
2. Knip M & Akerblom HK. Environmental factors in the pathogenesis of type 1 diabetes mellitus. Experimental Clinical Endocrinology and Diabetes 1999 107 S93-S100.
3. Akerblom HK & Knip M. Putative environmental factors in type 1 diabetes. Diabetes/Metabolism Reviews 1998 14 31-67.
4. Visser J, Klatter F, Vis L, Groen H, Strubbe J & Rozing J. Short-term dietary adjustment with a hydrolyzed casein based postpones diabetes development in the diabetes prone BB rat. Metabolism: Clinical and Experimental 2003 53 333-337.
5. Saldeen J. Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells. Endocrinology 2000 141 2003-2010.
6. Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes/Metabolism Reviews 1998 14 129-151.
7. Rabinovitch A, Suarez-Pinzon W, El Sheikh A, Sorensen O & Power RF. Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM. Diabetes 1996 45 749-754.
8. Kolb H, Worz-Pagenstert U, Kleemann R, Rothe H, Rowsell P & Scott FW. Cytokine gene expression in the BB rat pancreas: natural course and impact of bacterial vaccines. Diabetologia 1996 39 1448-1454.
9. Gottlieb PA & Eisenbarth GS. Insulin-specific tolerance in diabetes. Clinical Immunology 2002 102 2-11.
10. Jansen A, Rosmalen JG, Homo-Delarche F, Dardenne M & Drexhage HA. Effect of prophylactic insulin treatment on the number of ER-MP23 + macrophages in the pancreas of NOD mice. Is the prevention of diabetes based on beta-cell rest? Journal of Immunity 1996 9 341-348.
11. Gotfredsen CF, Buschard K & Frandsen EK. Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabetologia 1985 28 933-935.
12. Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP & Rossini AA. Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB rats. Diabetologia 1991 34 296-300.
13. Like AA, Kislauskis E, Williams RM, Williams RR & Rossini AA. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science 1982 216 644-646.
14. Burstein D, Mordes JP, Greiner W, Stein D, Nakamura N, Handler ES et al. Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection. Diabetes 1989 38 24-30.
15. Visser J, Groen H, Klatter F & Rozing J. Timing of pentoxifylline treatment determines its protective effect on diabetes development in the Bio Breeding rat. European Journal of Pharmacology 2002 445 133-140.
16. Garofano A, Czernichow P & Breant B. Beta-cell mass and proliferation following late fetal and early postnatal malnutrition in the rat. Diabetologia 1998 41 1114-1120.
17. Chen MC, Proost P, Gysemans C, Mathieu C & Eizerik DL. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia 2001 44 325-332.
18. Piemonti L, Leone BE, Nano R, Saccani A, Monti P, Maffi P et al. Human pancreatic islets produce and secrete MCP-1/CCL2: elevance in human islet transplantation. Diabetes 2002 51 55-65.
19. Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Hollander GA et al. β-cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nature Medicine 2002 8 1414-1420.
20. Luster AD. Chemokines - chemotactic cytokines that mediate inflammation. New England Journal of Medicine 1998 338 436-445.
21. Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? Journal of Clinical Endocrinology and Metabolism 2001 86 3257-3265.
22. Dandona P, Aljada A & Mohanty P. The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm. Diabetologia 2002 45 924-930.
23. Anastasi E, Dotta F, Tiberti C, Vecci E, Ponte E & Di Mario U. Insulin prophylaxis down-regulates islet antigen expression and islet autoimmunity in the low-dose Stz mouse model of diabetes. Autoimmunity 1999 29 249-256.
24. Aaen K, Rygaard J, Josefsen K, Petersen H, Brogren CH, Horn T et al. Dependence of antigen expression on functional state of beta-cells. Diabetes 1990 39 697-701.
25. Delemarre FG, Simons PJ & Drexhage HA. The BB rat as a model for autoimmune thyroiditis: relevance for the pathogenesis of human disease. Experimental and Clinical Endocrinology and Diabetes 1996 104 10-12.
26. Mooij P. The thyroid, iodine and autoimmunity. PhD Thesis University of Rotterdam, The Netherlands, 1993.
27. Diabetes Prevention Trial - Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. New England Journal of Medicine 2002 346 1685-1691.