Optimizing the antibacterial activity of a lead structure discovered by 'SAR by MS' technology

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5257-5261

  Jefferson, Elizabeth A ^a   Seth, Punit P ^a   Robinson, Dale E ^a   Winter, Dana K ^a   Miyaji, Alycia ^a   Risen, Lisa M ^a   Osgood, Stephen A ^a   Bertrand, Myra ^a   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

Antibacterial; Biaryl; MIC; RNA

Indexed keywords

POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MASS SPECTROMETRY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; FURANS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MASS SPECTROMETRY; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; RNA, RIBOSOMAL, 23S; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 5344237422     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.033     Document Type: Article

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