Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5285-5288

  Van Dort, Marcian E ^a,b   Jung, Yong Woon ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Girindus America Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 (4 HYDROXYBUTYL) 4,4 DIMETHYL 2,5 DIOXO 1 IMIDAZOLIDINYL] 2 TRIFLUOROMETHYLBENZONITRILE; ANDROGEN RECEPTOR; BENZYL DERIVATIVE; HYDANTOIN DERIVATIVE; IODINE; RADIOLIGAND; RU 59063; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; HYDANTOINS; IMIDAZOLES; IODINE RADIOISOTOPES; LIGANDS; MALE; NITRILES; PROSTATE; RADIOLIGAND ASSAY; RATS; RECEPTORS, ANDROGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5344236079     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.031     Document Type: Article

References (17)

1. A. Jemal, R.C. Tiwari, T. Murray, A. Gafoor, A. Samuels, E. Ward, E.J. Feuer, and M.J. Thun CA Cancer J. Clin. 54 2004 8 29
2. C.A. Heinlein, and C. Chang Endocrine Rev. 25 2 2004 276 308
3. A. Hobisch, Z. Culig, C. Radmayr, G. Bartsch, H. Klocker, and A. Hittmair Prostate 28 1996 129
4. J.A. Katzenellenbogen J. Nucl. Med. 36 1995 8S
5. P.D. Cutler, F. Dehdashti, B.A. Siegel, J.B. Downer, and M.J. Welch J. Nucl. Med. 37 1996 87P
6. P.K. Garg, D.C. Labaree, R.M. Hoyte, and R.B. Hochberg Nucl. Med. Biol. 28 2001 85 90
7. M.J. Welch, J.B. Downer, and J.A. Katzenellenbogen S.J. Mather Current Directions in Radiopharmaceutical Research and Development 1996 Kluwer Dordrecht 137 156
8. T. Battmann, A. Bonfils, C. Branche, J. Humbert, F. Goubet, G. Teutsch, and D. Philibert J. Steroid Biochem. Mol. Biol. 48 1994 55
9. G. Teutsch, F. Goubet, T. Battmann, A. Bonfils, F. Bouchoux, E. Cerede, D. Gofflo, M. Gaillard-Kelly, and D. Philibert J. Steroid Biochem. Mol. Biol. 48 1994 111
10. M.E. Van Dort, D.M. Robins, and B. Wayburn J. Med. Chem. 43 2000 3344
11. Van Dort, M. E.; Sherman, P. S., unpublished findings
12. D. Cousty-Berlin, B. Bergaud, M.C. Bruyant, T. Battmann, C. Branche, and D. Philibert J. Steroid Biochem. Mol. Biol. 51 1994 47 55
13. Androgen receptor binding assays were conducted by a commercial laboratory (MDS Panlabs, Bothell, WA, USA)
14. K. Schilling, and S. Liao Prostate 5 1984 581
15. S. Liao, D. Witte, K. Schilling, and C. Chang J. Steroid Biochem. 20 1984 11
16. M.E. Van Dort, and Y.-W. Jung Bioorg. Med. Chem. Lett. 11 2001 1045
17. T. Battmann, C. Branche, F. Bouchoux, E. Cerede, D. Philibert, F. Goubet, G. Teutsch, and M. Gaillard-Kelly J. Steroid Biochem. Mol. Biol. 64 1998 103