Synthesis of anthracyclinone precursor: 5,12-dihydroxy-1,3,4- trihydronaphthacene-2,6,11-quinone

Synthetic Communications

Volumn 34, Issue 17, 2004, Pages 3047-3059

  Tririya, Gasirat ^a   Zanger, Murray ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

4 demethoxyaglycones; Anthracyclines; Anthracyclinones; Daunorubicin; Doxorubicin; Idarubicin

Indexed keywords

5,12 DIHYDROXY 1,3,4 TRIHYDRONAPHTHACENE 2,6,11 QUINONE; ANTHRACYCLINONE DERIVATIVE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; MATERIALS; PRECURSOR; TOXICITY;

EID: 5344226987     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-200028508     Document Type: Article

References (15)

1. Arcamone, F. Doxorubicin Anticancer Antibiotics; Medicinal Chemistry, Academic Press: New York, 1981; Vol. 17.
2. Weiss, R.B. Semin. Oncol. 1992, 19, 670.
3. Arcamone, F.; Animati, F.; Capranico, G.; Lombardi, P.; Pratesi, G.; Manzini, S.; Supino, R.; Zunino, F. Pharmacol. Ther. 1997, 76, 117.
4. (a) Kelly, T.R. Annu. Rep. Med. Chem. 1979, 14, 288;
5. (b) Krohn, K. Angew. Chem. Int. Ed. Engl. 1986, 25, 790.
6. Kende, A.S.; Mills, J.E.; Tsay, Y United States Patent 4,021,457, May 3, 1977.
7. Rickborn, B. Comprehensive Organic Synthesis; Pergamon Press: New York, 1991; Vol. 3, 733.
8. Williamson, K.L.; Coburn, J.I.; Herr, M.F. J. Org. Chem. 1967, 32, 3934.
9. Grob, C.A.; Jundt, W. Helv. Chim. Acta 1952, 35, 2111.
10. (a) Scott, R.P. United States Patent 2,379,460, July 3, 1945;
11. (b) Fieser, L.F. J. Am. Chem. Soc. 1948, 70, 3165.
12. Hiers, G.S.; Hager, F.D. Organic Syntheses, Collected; Vol. I; 58.
13. McDonald, R.N.; Tabor, T.E. J. Am. Chem. Soc. 1967, 89, 6573.
14. Blade, R.J.; Hodge, P.J.C.S. Chem. Commun. 1979, 1, 85.
15. Arcamone, F.; Bernadi, L.; Patelli, B.; Di Marco, A.; Casazza, A.M.; Sorano, C.; Pratesi, G. Experientia 1978, 34, 1255.