메뉴 건너뛰기




Volumn 38, Issue 11, 2008, Pages 1130-1139

Rapamycin prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice

Author keywords

Angiogenesis; Hyperdynamic circulation; Portal hypertension; Sirolimus

Indexed keywords

CD31 ANTIGEN; PLACEBO; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; VASCULOTROPIN;

EID: 53349156840     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2008.00369.x     Document Type: Article
Times cited : (16)

References (34)
  • 1
    • 0025972590 scopus 로고
    • Hyperdynamic circulation in cirrhosis: A role for nitric oxide?
    • Vallance P, Moncada S. Hyperdynamic circulation in cirrhosis: A role for nitric oxide? Lancet 1991; 337: 776-8.
    • (1991) Lancet , vol.337 , pp. 776-778
    • Vallance, P.1    Moncada, S.2
  • 2
    • 0032899694 scopus 로고    scopus 로고
    • Vascular endothelial growth factor production in peritoneal macrophages of cirrhotic patients: Regulation by cytokines and bacterial lipopolysaccharide
    • Perez-Ruiz M, Ros J, Morales-Ruiz M et al. Vascular endothelial growth factor production in peritoneal macrophages of cirrhotic patients: regulation by cytokines and bacterial lipopolysaccharide. Hepatology 1999; 29: 1057-63.
    • (1999) Hepatology , vol.29 , pp. 1057-1063
    • Perez-Ruiz, M.1    Ros, J.2    Morales-Ruiz, M.3
  • 4
    • 0034998782 scopus 로고    scopus 로고
    • In vivo angiogenesis in normal and portal hypertensive rats: Role of basic fibroblast growth factor and nitric oxide
    • Sieber CC, Sumanovski LT, Stumm M, van der Kooij M, Battegay E. In vivo angiogenesis in normal and portal hypertensive rats: Role of basic fibroblast growth factor and nitric oxide. J Hepatol 2001; 34: 644-50.
    • (2001) J Hepatol , vol.34 , pp. 644-650
    • Sieber, C.C.1    Sumanovski, L.T.2    Stumm, M.3    van der Kooij, M.4    Battegay, E.5
  • 5
    • 0034872638 scopus 로고    scopus 로고
    • Increased production of vascular endothelial growth factor in peritoneal macrophages of cirrhotic patients with spontaneous bacterial peritonitis
    • Cejudo-Martin P, Ros J, Navasa M et al. Increased production of vascular endothelial growth factor in peritoneal macrophages of cirrhotic patients with spontaneous bacterial peritonitis. Hepatology 2001; 34: 487-93.
    • (2001) Hepatology , vol.34 , pp. 487-493
    • Cejudo-Martin, P.1    Ros, J.2    Navasa, M.3
  • 6
    • 1542347683 scopus 로고    scopus 로고
    • Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice
    • Fernandez M, Vizzutti F, Garcia-Pagan JC, Rodes J, Bosch J. Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice. Gastroenterology 2004; 126: 886-94.
    • (2004) Gastroenterology , vol.126 , pp. 886-894
    • Fernandez, M.1    Vizzutti, F.2    Garcia-Pagan, J.C.3    Rodes, J.4    Bosch, J.5
  • 7
    • 20444367984 scopus 로고    scopus 로고
    • F receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats
    • Fernandez M, Mejias M, Angermayr B et al. F receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. J Hepatol 2005; 43: 98-103.
    • (2005) J Hepatol , vol.43 , pp. 98-103
    • Fernandez, M.1    Mejias, M.2    Angermayr, B.3
  • 8
    • 33746704304 scopus 로고    scopus 로고
    • Increased angiogenesis and permeability in the mesenteric microvasculature of rats with cirrhosis and portal hypertension: An in vivo study
    • Geerts AM, De Vriese AS, Vanheule E et al. Increased angiogenesis and permeability in the mesenteric microvasculature of rats with cirrhosis and portal hypertension: An in vivo study. Liver Int 2006; 26: 889-98.
    • (2006) Liver Int , vol.26 , pp. 889-898
    • Geerts, A.M.1    De Vriese, A.S.2    Vanheule, E.3
  • 9
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932-6.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 10
    • 0029559927 scopus 로고
    • Molecular mechanisms of immunosuppression by cyclosporin, FK506 and rapamycin
    • Cardenas ME, Zhu D, Heitman J. Molecular mechanisms of immunosuppression by cyclosporin, FK506 and rapamycin. Curr Opin Nephrol Hypertens 1995; 4: 472-7.
    • (1995) Curr Opin Nephrol Hypertens , vol.4 , pp. 472-477
    • Cardenas, M.E.1    Zhu, D.2    Heitman, J.3
  • 11
    • 0028869086 scopus 로고
    • Rapamune (sirolimus, rapamycin): An overview and mechanism of action
    • Sehgal SN. Rapamune (sirolimus, rapamycin): An overview and mechanism of action. Ther Drug Monit 1995; 17: 660-5.
    • (1995) Ther Drug Monit , vol.17 , pp. 660-665
    • Sehgal, S.N.1
  • 12
    • 0842281690 scopus 로고    scopus 로고
    • Sirolimus: A ten-year perspective
    • Kahan BD. Sirolimus: A ten-year perspective. Transplant Proc 2004; 36: 71-5.
    • (2004) Transplant Proc , vol.36 , pp. 71-75
    • Kahan, B.D.1
  • 13
    • 6044243632 scopus 로고    scopus 로고
    • Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
    • Stephan S, Datta K, Wang E et al. Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. Clin Cancer Res 2004; 10: 6993-7000.
    • (2004) Clin Cancer Res , vol.10 , pp. 6993-7000
    • Stephan, S.1    Datta, K.2    Wang, E.3
  • 14
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M, Rowinsky EK. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 2000; 19: 6680-6.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 15
    • 0035993565 scopus 로고    scopus 로고
    • Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth
    • Schumacher G, Oidtmann M, Rosewicz S et al. Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth. Transplant Proc 2002; 34: 1392-3.
    • (2002) Transplant Proc , vol.34 , pp. 1392-1393
    • Schumacher, G.1    Oidtmann, M.2    Rosewicz, S.3
  • 16
    • 24644445998 scopus 로고    scopus 로고
    • Rapamycin: An anti-cancer immunosuppressant?
    • Law BK. Rapamycin: An anti-cancer immunosuppressant? Crit Rev Oncol Hematol 2005; 56: 47-60.
    • (2005) Crit Rev Oncol Hematol , vol.56 , pp. 47-60
    • Law, B.K.1
  • 17
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, Von Beitenbuch P, Steinbauer M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-35.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Beitenbuch, P.2    Steinbauer, M.3
  • 18
    • 21644469886 scopus 로고    scopus 로고
    • Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
    • Guba M, Koehl GE, Neppl E et al. Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer. Transpl Int 2005; 18: 89-94.
    • (2005) Transpl Int , vol.18 , pp. 89-94
    • Guba, M.1    Koehl, G.E.2    Neppl, E.3
  • 19
    • 2642527836 scopus 로고    scopus 로고
    • Vascular hyporesponsiveness in the mesenteric artery of rats with cirrhosis and portal hypertension: An in vivo study
    • Colle I, De Vriese AS, Van Vlierberghe H, Lameire N, De Vos M. Vascular hyporesponsiveness in the mesenteric artery of rats with cirrhosis and portal hypertension: An in vivo study. Eur J Gastroenterol Hepatol 2004; 16: 139-45.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 139-145
    • Colle, I.1    De Vriese, A.S.2    Van Vlierberghe, H.3    Lameire, N.4    De Vos, M.5
  • 20
    • 0032738763 scopus 로고    scopus 로고
    • Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
    • Zhu J, Wu J, Frizell E et al. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 1999; 117: 1198-204.
    • (1999) Gastroenterology , vol.117 , pp. 1198-1204
    • Zhu, J.1    Wu, J.2    Frizell, E.3
  • 21
    • 19444366644 scopus 로고    scopus 로고
    • Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: Analysis of the underlying mechanisms
    • Biecker E, De Gottardi A, Neef M et al. Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: Analysis of the underlying mechanisms. J Pharmacol Exp Ther 2005; 313: 952-61.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 952-961
    • Biecker, E.1    De Gottardi, A.2    Neef, M.3
  • 22
    • 33750433893 scopus 로고    scopus 로고
    • Low dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
    • Neef M, Ledermann M, Saegesser H, Schneider V, Reichen J. Low dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis. J Hepatol 2006; 45: 786-96.
    • (2006) J Hepatol , vol.45 , pp. 786-796
    • Neef, M.1    Ledermann, M.2    Saegesser, H.3    Schneider, V.4    Reichen, J.5
  • 23
    • 36348935694 scopus 로고    scopus 로고
    • Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats
    • Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J. Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats. Hepatology 2007; 46: 1208-17.
    • (2007) Hepatology , vol.46 , pp. 1208-1217
    • Fernandez, M.1    Mejias, M.2    Garcia-Pras, E.3    Mendez, R.4    Garcia-Pagan, J.C.5    Bosch, J.6
  • 25
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, Ali SM, Sengupta S et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006; 22: 159-68.
    • (2006) Mol Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3
  • 26
    • 33746800144 scopus 로고    scopus 로고
    • Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
    • Phung TL, Ziv K, Dabydeen D et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 2006; 10: 159-70.
    • (2006) Cancer Cell , vol.10 , pp. 159-170
    • Phung, T.L.1    Ziv, K.2    Dabydeen, D.3
  • 27
    • 20444410027 scopus 로고    scopus 로고
    • Ascites from cirrhotic patients induces angiogenesis through the phopshoinositide 3-kinase/Akt signaling pathway
    • Morales-Ruiz M, Tugues S, Cejudo-Martin P et al. Ascites from cirrhotic patients induces angiogenesis through the phopshoinositide 3-kinase/Akt signaling pathway. J Hepatol 2005; 43: 85-91.
    • (2005) J Hepatol , vol.43 , pp. 85-91
    • Morales-Ruiz, M.1    Tugues, S.2    Cejudo-Martin, P.3
  • 28
    • 22344434535 scopus 로고    scopus 로고
    • Norfloxacin reduces aortic NO synthases and proinflammatory cytokine up-regulation in cirrhotic rats: Role of Akt signaling
    • Tazi KA, Moreau R, Hervé P et al. Norfloxacin reduces aortic NO synthases and proinflammatory cytokine up-regulation in cirrhotic rats: role of Akt signaling. Gastroenterology 2005; 129: 303-14.
    • (2005) Gastroenterology , vol.129 , pp. 303-314
    • Tazi, K.A.1    Moreau, R.2    Hervé, P.3
  • 29
    • 0036151948 scopus 로고    scopus 로고
    • Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI3-kinase-Akt signaling pathway
    • Kawanaka H, Jones MK, Szabo IL et al. Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI3-kinase-Akt signaling pathway. Hepatology 2002; 35: 393-402.
    • (2002) Hepatology , vol.35 , pp. 393-402
    • Kawanaka, H.1    Jones, M.K.2    Szabo, I.L.3
  • 30
    • 33745845536 scopus 로고    scopus 로고
    • Upregulation of TNF-alpha production signaling pathways in monocytes from patient with advanced cirrhosis: Possible role of Akt and IRAK-M
    • Tazi KA, Quioc JJ, Saada V, Bezeaud A, Lebrec D, Moreau R. Upregulation of TNF-alpha production signaling pathways in monocytes from patient with advanced cirrhosis: Possible role of Akt and IRAK-M. J Hepatol 2006; 45: 280-9.
    • (2006) J Hepatol , vol.45 , pp. 280-289
    • Tazi, K.A.1    Quioc, J.J.2    Saada, V.3    Bezeaud, A.4    Lebrec, D.5    Moreau, R.6
  • 31
    • 0037111665 scopus 로고    scopus 로고
    • BCR/ABL induces expression of vascular growth factor and its transcriptional activator, hypoxia inducible factor-1a, through a pathway involving phosphoinositide-3-kinase and the mammalian target of rapamycin
    • Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C. BCR/ABL induces expression of vascular growth factor and its transcriptional activator, hypoxia inducible factor-1a, through a pathway involving phosphoinositide-3-kinase and the mammalian target of rapamycin. Blood 2002; 100: 3767-75.
    • (2002) Blood , vol.100 , pp. 3767-3775
    • Mayerhofer, M.1    Valent, P.2    Sperr, W.R.3    Griffin, J.D.4    Sillaber, C.5
  • 32
    • 8544273759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1a, HDM2, and p70SK1 in response to phosphatidylinositol 3-kinase/AKT signaling
    • Skinner HD, Zheng JZ, Fang J, Agani F, Jiang B. Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1a, HDM2, and p70SK1 in response to phosphatidylinositol 3-kinase/AKT signaling. J Biol Chem 2004; 29: 45643-51.
    • (2004) J Biol Chem , vol.29 , pp. 45643-45651
    • Skinner, H.D.1    Zheng, J.Z.2    Fang, J.3    Agani, F.4    Jiang, B.5
  • 33
    • 33748562106 scopus 로고    scopus 로고
    • Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1a
    • Lu DY, Liou HC, Tang CH, Fu WM. Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1a. Biochem Pharmacol 2006; 72: 992-1000.
    • (2006) Biochem Pharmacol , vol.72 , pp. 992-1000
    • Lu, D.Y.1    Liou, H.C.2    Tang, C.H.3    Fu, W.M.4
  • 34
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signalin
    • Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signalin. FASEB 2002; 16: 771-80.
    • (2002) FASEB , vol.16 , pp. 771-780
    • Humar, R.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.