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The reports on asymmetric organocatalysis have been growing exponentially even when normalized against the general growth in all scientific publications
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The reports on asymmetric organocatalysis have been growing exponentially even when normalized against the general growth in all scientific publications.
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Curiously, long before the explosion of organocatalysis, acetaldehyde itself may be considered one of the first compounds used as an organocatalyst: J. von Liebig, Justus Liebigs Ann. Chem. 1860, 113, 246.
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Curiously, long before the explosion of organocatalysis, acetaldehyde itself may be considered one of the first compounds used as an organocatalyst: J. von Liebig, Justus Liebigs Ann. Chem. 1860, 113, 246.
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The configuration of the product is imposed by the bulkiness of the substituent α to the pyrrolidine nitrogen atom, forcing the attack of the electrophile to the lower face of the enamine. Thus, the configuration of the final adducts is opposite to that for the L-proline-catalyzed reactions
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The configuration of the product is imposed by the bulkiness of the substituent α to the pyrrolidine nitrogen atom, forcing the attack of the electrophile to the lower face of the enamine. Thus, the configuration of the final adducts is opposite to that for the L-proline-catalyzed reactions.
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It should be mentioned that the enantioselectivity of the L-proline catalyzed Mannich reaction is opposite to that of the sterochemistry observed for the corresponding L-proline catalyzed aldol reaction.
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