Pharmacokinetic study of clazuril (Appertex®) in eggs and plasma from laying hens after single or multiple treatments, using a new HPLC method for detection

British Poultry Science

Volumn 49, Issue 5, 2008, Pages 609-618

  Giorgi, M ^a   Soldani, G ^a  

^a Department of Veterinary Clinics ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE DERIVATIVE; ALBUMINOID; CLAZURIL; COCCIDIOSTATIC AGENT; DRUG RESIDUE; TRIAZINE DERIVATIVE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; AREA UNDER THE CURVE; ARTICLE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; CHICKEN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ADMINISTRATION; EGG; EGG YOLK; FEMALE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; RANDOMIZED CONTROLLED TRIAL; REPRODUCIBILITY;

ACETONITRILES; ALBUMINS; ANIMAL FEED; ANIMALS; AREA UNDER CURVE; CHICKENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCCIDIOSTATS; DRUG ADMINISTRATION SCHEDULE; DRUG RESIDUES; EGG YOLK; EGGS; FEMALE; HALF-LIFE; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; TRIAZINES;

EID: 53349141495     PISSN: 00071668     EISSN: 14661799     Source Type: Journal    
DOI: 10.1080/00071660802294566     Document Type: Article

References (15)

1. CARPENTER, J.W., NOVILLA, M.N. & HATFIELD, J.S. (2005) Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge. Journal of Zoo and Wildlife Medicine, 36: 391-400.
2. CHAPMAN, H.D. (2000) Practical use of vaccines for the control of coccidiosis in the chicken. World's Poultry Science Journal, 56: 7-20.
3. COUSSEMENT, W., MAES, L., VANPARIJS, O. & MARSBOOM, R. (1988) Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E. columbarum in experimentally infected pigeons. Research Veterinary Science, 45: 117-119.
4. DALLOUL, R.A. & LILLEHOJ, H.S. (2006) Poultry coccidiosis: recent advancements in control measures and vaccine development. Expert Review of Vaccines, 5: 143-163.
5. EUROPEAN COMMISSION (1986) EEC Council Directive No. 609. Official Journal of the European Communities, L358: 1-29.
6. EUROPEAN COMMISSION (1990) EEC Council Regulation No. 2377/90. Official Journal of the European Communities, L224/1: 1-8.
7. EUROPEAN COMMISSION (2002) Commission Decision (2002/657/EC) of 12 August 2002, Brussels, Belgium. Official Journal of the European Communities, L221: 8-36.
8. KENNEDY, D.G., HUGHES, P.J. & BLANCHFLOWER, W.J. (1998) Ionophore residues in eggs in Northern Ireland: incidence and cause. Food Additives and Contaminants, 15: 535-541.
9. MAES, L., COUSSEMENT, W., DESPLENTER, L. & MARSBOOM, R. (1988) Safety of a new anticoccidial agent, clazuril, during reproduction in carrier pigeons. Tijdschrift voor Diergeneeskunde, 113: 195-204.
10. MORTIER, L., HUET, A.C., CHARLIER, C., DAESELEIRE, E., DELAHAUT, P. & VAN PETEGHEM:, C. (2005) Incidence of residues of nine anticoccidials in eggs. Food Additives and Contaminants, 22: 1120-1125.
11. SAUVEUR, B. (1988) Reproduction des volailles et production d'oeufs (Paris, INRA).
12. VANPARIJS, O., HERMANS, L., VAN DER FLAES, L., VLAMINCK, K. & MARSBOOM, R. (1988) Clazuril: a new anticoccidial agent for pigeons. Tijdschrift voor Diergeneeskunde, 113: 190-194.
13. VERCRUYSSE, J. (1990) Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Disease, 34: 73-79.
14. www.faw.be (accessed August 2007).
15. YAMAOKA, K., NAKAGAWA, T. & UNO, T. (1978) Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics, 6: 165-175.