Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer

Biochemical and Biophysical Research Communications

Volumn 277, Issue 1, 2000, Pages 93-99

  Alenghat, Francis J ^a   Fabry, Ben ^b   Tsai, Kenneth Y ^a   Goldmann, Wolfgang H ^a   Ingber, Donald E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Focal adhesion; Integrin; Magnetometry; Mechanical stress; Mechanotransduction; Vinculin

Indexed keywords

INTEGRIN; LIGAND; MEMBRANE RECEPTOR; VINCULIN;

ADHESION; ANIMAL CELL; ARTICLE; BIOMECHANICS; CELL; DEVICE; EMBRYO; FORCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRESS;

ANIMALIA;

EID: 0034649110     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3636     Document Type: Article

References (38)

1. Role of cell shape in growth control
2. Fibronectin controls capillary endothelial cell growth by modulating cell shape
3. Switching from differentiation to growth in hepatocytes: Control by extracellular matrix
4. Engineering cell shape and function
5. Geometric control of cell life and death
6. Mechanical control of cyclic AMP signalling and gene transcription through integrins
7. Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal, and nuclear shape
8. Shear stress-induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy
9. Role of the cytoskeleton in genome regulation and cancer
10. The riddle of morphogenesis: A question of solution chemistry or molecular cell engineering?
11. Integrins as mechanochemical transducers
12. Cellular tensegrity: Defining new rules of biological design that govern the cytoskeleton
13. Passive mechanical properties of human leukocytes
14. Erythrocyte membrane elasticity and viscosity
15. Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration
16. Cell poking. Determination of the elastic area compressibility modulus of the erythrocyte membrane
17. Cell poking: Quantitative analysis of indentation of thick viscoelastic layers
18. Mechanical manipulation of animal cells: Cell indentation
19. Response of porcine aortic smooth muscle cells to cyclic tensional deformation in culture
20. Computer-aided mechanogenesis of skeletal muscle organs from single cells in vitro
21. The study of rheological effects on vascular endothelial cells in culture
22. Stress mechanisms in cultured cells: An endothelial paradigm
23. Fluid shear stress activation of IκB kinase is integrin-dependent
24. Mechanotransduction across the cell surface and the cytoskeleton
25. Force of single kinesin molecules measured with optical tweezers
26. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
27. Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension
28. Measurement of local viscoelasticity and forces in living cells by magnetic tweezers
29. Integrin-cytoskeletal interactions in neuronal growth cones
30. Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry
31. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
32. Differences in elasticity of vinculin-deficient F9 cells measured by magnetometry and atomic force microscopy
33. Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton
34. F-actin binding site masked by the intramolecular association of vinculin head and tail domains
35. Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate
36. Focal adhesion formation by F9 embryonal carcinoma cells after vinculin gene disruption
37. Rapid induction and isolation of focal adhesion complexes
38. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function