Effect of proteolytic activity of Epicoccum purpurascens major allergen, Epi p 1 in allergic inflammation

Clinical and Experimental Immunology

Volumn 154, Issue 2, 2008, Pages 162-171

  Kukreja, N ^a,b   Sridhara, S ^a   Singh, B P ^a   Arora, N ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Allergen; Allergic inflammation; Epicoccum purpurascens; Mice model; Serine protease

Indexed keywords

ALLERGEN; CYTOKINE; EPI P 1; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BLOOD SAMPLING; CELL CULTURE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPICOCCUM PURPURASCENS; FUNGUS; GOBLET CELL; HISTOPATHOLOGY; INFLAMMATION; LUNG LAVAGE; LUNG PARENCHYMA; MALE; METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPLEEN; SPLEEN CELL;

ALLERGENS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; EOSINOPHIL PEROXIDASE; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; LUNG; MICE; MICE, INBRED BALB C; OVALBUMIN; PHYTOHEMAGGLUTININS; RESPIRATORY HYPERSENSITIVITY; SERINE ENDOPEPTIDASES; SPLEEN;

EID: 53349118360     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03762.x     Document Type: Article

References (35)

1. Jeong SK, Kim HJ, Youm JK et al. Mite and cockroach allergens activate protease activated receptor-2 and delay epidermal permeability barrier recovery. J Invest Dermatol 2008 128 : 1930 9.
2. Runswick S, Mitchell T, Davies P, Robinson C, Garrod DR. Pollen proteolytic enzymes degrade tight junctions. Respirology 2007 12 : 834 42.
3. Shen HD, Tam MF, Tang RB, Chou H. Aspergillus and Penicillium allergens: focus on proteases. Curr Allergy Asthma Rep 2007 7 : 351 6.
4. Ghaemmaghami AM, Gough L, Sewell HF, Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level. Clin Exp Allergy 2002 32 : 1468 75.
5. Gough L, Schulz O, Sewell HF, Shakib F. The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response. J Exp Med 1999 190 : 1897 902.
6. Gough L, Campbell E, Bayley D, Van Heeke G, Shakib F. Proteolytic activity of the house dust mite allergen Der p 1 enhances allergenicity in a mouse inhalation model. Clin Exp Allergy 2003 33 : 1159 63.
7. Kikuchi Y, Takai T, Kuhara T et al. Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses. J Immunol 2006 177 : 1609 17.
8. Schwab CJ, Cooley JD, Jumper CJ, Graham SC, Straus DC. Allergic inflammation induced by a Penicillium chrysogenum conidia-associated allergen extract in a murine model. Allergy 2004 59 : 758 65.
9. Shin SH, Lee YH, Jeon CH. Protease-dependent activation of nasal polyp epithelial cells by airborne fungi leads to migration of eosinophils and neutrophils. Acta Otolaryngol 2006 126 : 1286 94.
10. Tai HY, Tam MF, Chou H et al. Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy 2006 61 : 382 8.
11. Kurup VP, Xia JQ, Shen HD et al. Alkaline serine proteinase from Aspergillus fumigatus has synergistic effects on Asp-f-2-induced immune response in mice. Int Arch Allergy Immunol 2002 129 : 129 37.
12. Kheradmand F, Kiss A, Xu J, Lee SH, Kolattukudy PE, Corry DB. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J Immunol 2002 169 : 5904 11.
13. Kauffman HF, Tomee JF, van de Riet MA, Timmerman AJ, Borger P. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol 2000 105 : 1185 93.
14. Bisht V, Singh BP, Arora N, Sridhara S, Gaur SN. Allergens of Epicoccum nigrum grown in different media for quality source material. Allergy 2000 55 : 274 80.
15. Dixit AB, Lewis WH, Wedner HJ. The allergens of Epicoccum nigrum link. I. Identification of the allergens by immunoblotting. J Allergy Clin Immunol 1992 90 : 11 20.
16. Bisht V, Arora N, Singh BP, Pasha S, Gaur SN, Sridhara S. Epi p 1, an allergenic glycoprotein of Epicoccum purpurascens is a serine protease. FEMS Immunol Med Microbiol 2004 42 : 205 11.
17. Kukreja N, Singh BP, Arora N, Gaur SN, Sridhara S. Identification of Epicoccum purpurascens allergens by two-dimensional immunoblotting and mass spectrometry. Immunobiology 2008 213 : 65 73.
18. Bisht V, Arora N, Singh BP, Gaur SN, Sridhara S. Purification and characterization of a major cross-reactive allergen from Epicoccum purpurascens. Int Arch Allergy Immunol 2004 133 : 217 24.
19. Kukreja N, Arora N, Singh BP, Das HR, Sridhara S. Role of glycoproteins isolated from Epicoccum purpurascens in host-pathogen interaction. Pathobiology 2007 74 : 186 92.
20. Schneider T, van Velzen D, Moqbel R, Issekutz AC. Kinetics and quantitation of eosinophil and neutrophil recruitment to allergic lung inflammation in a brown Norway rat model. Am J Respir Cell Mol Biol 1997 17 : 702 12.
21. Inoue K, Takano H, Hiyoshi K et al. Naphthoquinone enhances antigen related airway inflammation in mice. Eur Respir J 2007 29 : 259 67.
22. Cui T, Kusunose M, Hamada A et al. Relationship between the eosinophilia of bronchoalveolar lavage fluid (BALF) and the severity of pulmonary fibrosis induced by bleomycin in rats. Biol Pharm Bull 2003 26 : 959 63.
23. Shankar J, Singh BP, Gaur SN, Arora N. Recombinant glutathione-S- transferase a major allergen from Alternaria alternata for clinical use in allergy patients. Mol Immunol 2006 43 : 1927 32.
24. Thompson PJ. Unique role of allergens and the epithelium in asthma. Clin Exp Allergy 1998 28 : 110 16.
25. Sun G, Stacey MA, Schmidt M, Mori L, Mattoli S. Interaction of mite allergens Der p 3 and Der p 9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol 2001 167 : 1014 21.
26. Su NY, Yu CJ, Shen HD, Pan FM, Chow LP. Pen c 1, a novel enzymic allergen protein from Penicillium citrinum. Purification, characterization, cloning and expression. Eur J Biochem 1999 261 : 115 23 erratum in: Eur J Biochem 1999; 261:821 T, Machado DC, Kolbe L et al. A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2. J Immunol 1995 155 : 2605 13.
27. Chapman MD, Wunschmann S, Pomes A. Proteases as Th2 adjuvants. Curr Allergy Asthma Rep 2007 7 : 363 7.
28. Hewitt CR, Brown AP, Hart BJ, Pritchard DI. A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. J Exp Med 1995 182 : 1537 44.
29. Shakib F, Schulz O, Sewell H. A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity. Immunol Today 1998 19 : 313 16.
30. Wan H, Winton HL, Soeller C et al. Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1. Clin Exp Allergy 2000 30 : 685 98.
31. Wan H, Winton HL, Soeller C et al. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin Exp Allergy 2001 31 : 279 94.
32. Havaux X, Zeine A, Dits A, Denis O. A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum moulds. Clin Exp Immunol 2005 139 : 179 88.
33. Simpson JL, Scott RJ, Boyle MJ, Gibson PG. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med 2005 172 : 559 65.
34. Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2007 9 : 310 18.
35. Suzuki M, Itoh M, Ohta N et al. Blocking of protease allergens with inhibitors reduces allergic responses in allergic rhinitis and other allergic diseases. Acta Otolaryngol 2006 126 : 746 51.