Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor

Clinical and Experimental Dermatology

Volumn 33, Issue 6, 2008, Pages 785-787

  Zhao, Y ^a   Makino, T ^b   Honda, A ^b   Shimizu, H ^a   Yamagishi, S ^c   Shimizu, T ^b  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAREBASTINE; EBASTINE; GAMMA INTERFERON; HISTAMINE H1 RECEPTOR ANTAGONIST; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE MIGRATION INHIBITION FACTOR; OKT 3; PHORBOL MYRISTATE; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC RHINITIS; ANTIINFLAMMATORY ACTIVITY; ASTHMA; ATOPIC DERMATITIS; CELL CULTURE; CELL PROLIFERATION; CELL SECRETION; CELL SUSPENSION; CHRONIC URTICARIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG TRANSFORMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE REPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; LETTER; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

BUTYROPHENONES; CELLS, CULTURED; HISTAMINE H1 ANTAGONISTS; HUMANS; INTERLEUKIN-6; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MONOCYTES; PIPERIDINES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 53349091996     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2008.02843.x     Document Type: Letter

References (5)

1. Kalis B. Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. Drugs 1996 52 (Suppl. 1 30 4.
2. Yakuo I, Ishii K, Seto Y et al. Pharmacological study of ebastine, a novel histamine H1-receptor antagonist. Folia Pharmacol Jpn 1994 103 : 121 35.
3. Nori M, Iwata S, Munakata Y et al. Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines. Clin Exp Allergy 2003 33 : 1544 54.
4. Shimizu T, Abe R, Ohkawara A et al. Macrophage migration inhibitory factor is an essential immunoregulatory cytokine in atopic dermatitis. Biochem Biophy Res Commun 1997 240 : 173 8.
5. Shimizu T, Abe R, Ohkawara A et al. Increased production of macrophage migration inhibitory factor (MIF) by PBMCs of atopic dermatitis. J Allergy Clin Immunol 1999 104 : 659 64.