Targeting α7-nicotinic receptor for the treatment of pleural mesothelioma

European Journal of Cancer

Volumn 44, Issue 15, 2008, Pages 2296-2311

  Catassi, Alessia ^a,b   Paleari, Laura ^a   Servent, Denis ^c   Sessa, Fausto ^b,d   Dominioni, Lorenzo ^b   Ognio, Emanuela ^a   Cilli, Michele ^a   Vacca, Paola ^a,e   Mingari, Mariacristina ^a,e   Gaudino, Giovanni ^f   Bertino, Pietro ^f   Paolucci, Massimo ^f,g   Calcaterra, Andrea ^g   Cesario, Alfredo ^h,i   Granone, Pierluigi ^h   Costa, Roberta ^j   Ciarlo, Monica ^a   Alama, Angela ^a   Russo, Patrizia ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^d IRCCS MULTIMEDICA   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^g Gallarate Hospital   (Italy)

^h CATHOLIC UNIVERSITY   (Italy)

ⁱ IRCCS SAN RAFFAELE PISANA   (Italy)

^j Hospital of Alessandria   (Italy)

more..

Author keywords

7 Nicotinic receptor; Antitumour activity; Apoptosis; Mesothelioma; Survivin

Indexed keywords

BUNGAROTOXIN RECEPTOR; CASPASE 3; CASPASE 3 INHIBITOR; COBROTOXIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MESSENGER RNA; PROTEIN BCL XL; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS; ALPHA-BUNGAROTOXIN RECEPTOR; ALPHA-COBRATOXIN; ANTINEOPLASTIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPSY; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFICACY; DRUG TARGETING; ENZYME DEGRADATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY NECROSIS; LD 50; MALE; MESOTHELIUM CELL; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; NUCLEOTIDE SEQUENCE; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY FAILURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THORAX RADIOGRAPHY; TUMOR CELL CULTURE; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CANCER TRANSPLANTATION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; MESOTHELIOMA; METABOLISM; METHODOLOGY; MOUSE MUTANT; PATHOLOGY; PLEURA TUMOR; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; COBRA NEUROTOXIN PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; MESOTHELIOMA; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NICOTINIC ANTAGONISTS; PLEURAL NEOPLASMS; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 53249154662     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.06.045     Document Type: Article

References (38)

1. Russo P., Catassi A., Cesario A., and Servent D. Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system. Curr Med Chem 13 (2006) 3493-3512
2. Paleari A, Grozio A, Cesario A, Russo P. The cholinergic system and cancer. Sem Cancer Biol [in press].
3. Catassi A, Paleari L, Cesario A, Russo P. Nicotine: a single agent in lung cancer induction and progression. Mut Res-Rev [in press].
4. Minna J.D. Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J Clin Invest 111 (2003) 31-33
5. Maus A.D., Pereira E.F., Karachunski P.I., et al. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol 54 (1998) 779-788
6. Zia S., Ndoye A., Nguyen V.T., and Grando S.A. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res. Commun Mol Pathol Pharmacol 97 (1997) 243-262
7. Maneckjee R., and Minna J.D. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci U S A 87 (1990) 3294-3298
8. Plummer HK I.I.I., Dhar M., and Schuller H.M. Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. Respir Res 6 (2005) 29-38
9. Wang Y., Pereira E.F., Maus A.D., et al. Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Mol Pharmacol 60 (2001) 1201-1209
10. Schuller H.M. Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines. Biochem Pharmacol 38 (1989) 3439-3442
11. West K.A., Brognard J., Clark A.S., et al. Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest 6 (2006) 2208-2217
12. Trombino S., Cesario A., Margaritora S., et al. Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. Cancer Res 64 (2004) 135-145 Erratum in: Cancer Res 2004; 64:1559
13. Lam D.C., Girard L., Ramirez R., et al. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Res 67 (2007) 4638-4647
14. Calmette A., Saenz A., and Costil L. Du venin de cobra sur les greffes canceréuses et sur le cancer spontané (adéno-carcinome) de la souris. CR Acad Sci 197 (2003) 205
15. Seliger H. New results with cobratoxin in cancer therapy. Med Welt 20 (1951) 638
16. Grozio A., Catassi A., Cavalieri Z., et al. Nicotine, lung andcancer. Anticancer Agents Med Chem 7 (2007) 461-466
17. Grozio A., Paleari L., Catassi A., et al. Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: A promising prospective in anti-cancer drug development. Int J Cancer (2007)
18. Orengo A.M., Spoletini L., Procopio A., et al. Establishment of four new mesothelioma cell lines: characterization by ultrastructural and immunophenotypic analysis. Eur Respir J 13 (1999) 527-534
19. Antil-Delbeke S., Gaillard C., Tamiya T., et al. Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor. J Biol Chem 275 (2000) 29594-29601
20. Trombino S., Cesario A., Margaritora S., et al. Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. Cancer Res 64 (2004) 135-145
21. Oates J., and Edwards C. HBME-1, MOC-31, WT1 and calretinin: an assessment of recently described markers for mesothelioma and adenocarcinoma. Histopathology 36 (2000) 341-347
22. Stevens K.E., Freedman R., Collins A.C., et al. Neuropsychopharmacol 15 (1996) 152-162
23. He L., Dinger B., and Fidone S. Effect of chronic hypoxia on cholinergic chemotransmission in rat carotid body. J Appl Physiol 98 (2005) 614-619
24. Davies A.R., Hardick D.J., Blagbrough I.S., et al. Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors. Neuropharmacol 38 (1999) 679-690
25. Keith B., and Simon M.C. Hypoxia-inducible factors, stem cells, and cancer. Cell 129 (2007) 465-472
26. Klabatsa A., Sheaff M.T., Steele J.P., et al. Expression and prognostic significance of hypoxia-inducible factor 1alpha (HIF-1alpha) in malignant pleural mesothelioma (MPM). Lung Cancer 51 (2006) 53-59
27. Singhal S., Wiewrodt R., Malden L.D., et al. Gene expression profiling of malignant mesothelioma. Clin Cancer Res 9 (2003) 3080-3097
28. Karlsson E., Arnberg H., and Eaker D. Isolation of the principal neurotoxins of two Naja naja subspecies. Eur J Biochem 15 (1971) 1-16
29. Servent D, and Ménez A Massaro EJ (Ed.). Handbook of neurotoxicology, Humana press Inc: Totowa, NJ; pp-385-425.
30. Keller S.H., Kreienkamp H.J., Kawanishi C., and Taylor P.L. Molecular determinants conferring alpha-toxin resistance in recombinant DNA-derived acetylcholine receptors. J Biol Chem 270 (1995) 4165-4171
31. Falleni M., Pellegrini C., Marchetti A., et al. Quantitative evaluation of the apoptosis regulating genes Survivin, Bcl-2 and Bax in inflammatory and malignant pleural lesions. Lung Cancer 48 (2005) 211-216
32. Wheatley S.P., and McNeish I.A. Survivin: a protein with dual roles in mitosis and apoptosis. Int Rev Cytol 247 (2005) 35-88
33. Dasgupta P., Kinkade R., Joshi B., et al. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc Natl Acad Sci U S A 103 (2006) 6332-6337
34. Russo P., Catassi A., Malacarne D., et al. Tumor necrosis factor enhances SN38-mediated apoptosis in mesothelioma cells. Cancer 103 (2005) 1503-1518
35. Ozvaran M.K., Cao X.X., Miller S.D., et al. Antisense oligonucleotides directed at the Bcl-xl gene product augment chemotherapy response in mesothelioma. Mol Cancer Ther 3 (2004) 545-550
36. Thomadaki H., Scorilas A., and Hindmarsh J.T. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Crit Rev Clin Lab Sci 43 (2006) 1-67
37. Lewis R.J., and Garcia M.L. Therapeutic potential of venom peptides. Nature Rev 2 (2003) 790-802
38. Russo P., Pala M., Parodi S., et al. Effects of vitamin E on liver DNA. Cancer Lett 25 (1984) 163-170