Synthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 5, 2008, Pages 617-622

  Chevreuil, Francis ^a   Landreau, Anne ^a   Seraphin, Denis ^a   Larcher, Gérald ^b   Bouchara, Jean Philippe ^b   Richomme, Pascal ^a  

^a UNIVERSITÉ D'ANGERS   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

Antifungal agents; Aspergillus fumigatus; Azide; Candida albicans; Candida glabrata; Conazole; Resistance

Indexed keywords

1 [2 AZIDO 2 (2,4 DICHLOROPHENYL) 2 PHENYLETHYL] 1H IMIDAZOLE; 1 [2 AZIDO 2 (2,4 DICHLOROPHENYL) 3 PHENYLPROPYL] 1H IMIDAZOLE; 1 [2 AZIDO 2 (2,4 DICHLOROPHENYL)BUT 3 ENYL] 1H IMIDAZOLE; 1 [2 AZIDO 2 (2,4 DICHLOROPHENYL)ETHYL] 1H IMIDAZOLE DERIVATIVE; 1 [2 AZIDO 2 (2,4 DICHLOROPHENYL)HEXYL] 1H IMIDAZOLE; 1 [2 AZIDO 2 (2,4 DICHLOROPHENYL)PENT 4 YNYL] 1H IMIDAZOLE; 2 (2,4 DICHLOROPHENYL) 1H IMIDAZOL 1 YL BUT 3 EN 2 OL; ANTIFUNGAL AGENT; FLUCONAZOLE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA GLABRATA; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALCOHOLS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; AZIDES; CANDIDA ALBICANS; CANDIDA GLABRATA; IMIDAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA GLABRATA;

EID: 53249132742     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802205133     Document Type: Article

References (22)

1. Fridkin, SK and Jarvis, WR (1996) Clin Microbiol Rev, 9, pp. 499-511.
2. Ablordeppey, SY, Fan, P., Ablordeppey, JH and Mardenborough, L. (1999) Curr Med Chem, 6, pp. 1151-1196.
3. Kleinberg, M. (2006) Int J Antimicrob Agents, 27, pp. 12-16.
4. Turner, MS, Drew, RH and Perfect, JR (2006) Expert Opin Emerg Drugs, 11, pp. 231-250.
5. Richardson, K., Cooper, K., Marriott, MS, Tarbit, MH, Troke, PF and Whittle, PJ (1990) Rev Infect Dis, 12, pp. 267-271.
6. Brun, S., Bergès, T., Poupard, P., Vauzelle-Moreau, C., Renier, G., Chabasse, D. and Bouchara, JP (2004) Antimicrob Agents Chemother, 481, pp. 1788-1796.
7. Chen, A. and Sobel, JD (2005) Expert Opin Emerg Drugs, 10, pp. 21-33.
8. Sundriyal, S., Sharma, RK and Jain, R. (2006) Curr Med Chem, 13, pp. 1321-1335.
9. Chevreuil, F., Landreau, A., Séraphin, D., Larcher, G., Bouchara, JP and Richomme, P. (2006) J Enz Inhib Med Chem, 21, pp. 293-303.
10. Chevreuil, F., Landreau, A., Séraphin, D., Larcher, G., Mallet, S., Bouchara, JP and Richomme, P. (2007) J Enz Inhib Med Chem, 22, pp. 563-569.
11. Nguyen-Hai, N., Sardari, S. and Selecky, M. (2004) Bioorgan Med Chem, 12, pp. 6255-6269.
12. Bentley, A., Butters, M. and Green, SP (2002) Organ Proc Res Develop, 6, pp. 109-112.
13. Shapiro, L. and Ganguly, AK (1974) Chem Abstr, 81, p. 91336.
14. Stuetz, A. and Egger, H. (1984) Chem Abstr, 102, p. 62244.
15. Bawden, D., Gymer, GE and Marriott, MS (1983) Eur J Med Chem, 18:1, pp. 91-96.
16. Jeager, G., Boeckmann, K. and Buechel, KH (1983) Chem Abstr, 100, p. 139121.
17. Jiyooji, AM and Haku, FC (1979) Chem Abstr, 91, p. 57005.
18. Scharwaechter, P., Gutsche, K. and Kohlmann, W. (1977) Chem Abstr, 88, p. 89672.
19. Godefroi, EF, Heeres, J., Van Custem, J. and Janssen, PA (1969) J Med Chem, 12, pp. 784-791.
20. Perez, ER, Loupy, A., Liagre, M., De Guzzi Plepis, AM and Cordeiro, PJ (2003) Tetrahedron, 59, pp. 865-870.
21. National Commitee for Clinical Laboratory Standards (1997) Reference method for broth dilution antifungal susceptibility testing yeasts. Approved standard M27-A, National Commitee for Clinical Standards, Villanova, PA
22. Harriman, GCB, Shao, J. and Luly, JR (2000) Tetrahedron Lett, 41, pp. 8853-8856.