Glutamine Induces Heat-Shock Protein-70 and Glutathione Expression and Attenuates Ischemic Damage in Rat Islets

Transplantation Proceedings

Volumn 40, Issue 8, 2008, Pages 2581-2584

  Jang, H J ^a   Kwak, J H ^a   Cho, E Y ^b   We, Y M ^b   Lee, Y H ^b   Kim, S C ^b   Han, D J ^b  

^a University of Ulsan   (South Korea)

^b Asan Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; GLUTATHIONE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 1BETA; NITRIC OXIDE; NITRITE; PROTEIN BCL 2; REAGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL ISOLATION; CELL LEVEL; CONTROLLED STUDY; INFLAMMATION; ISCHEMIA; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; GLUCOSE; GLUTAMINE; GLUTATHIONE; HOT TEMPERATURE; HSP70 HEAT-SHOCK PROTEINS; INSULIN; ISCHEMIA; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 53149153889     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2008.08.075     Document Type: Article

References (15)

1. Shapiro A.M., Lakey J.R., Ryan E.A., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343 (2000) 230
2. Berney T., and Ricordi C. Islet cell transplantation: The future?. Langenbecks Arch Surg 385 (2000) 373
3. Vajkoczy P., Olofsson A.M., Lehr H.A., et al. Histogenesis and ultrastructure of pancreatic islet graft microvasculature: evidence for graft revascularization by endothelial cells of host origin. Am J Pathol 146 (1995) 1397
4. Scarim A.M., Heitmeier M.R., and Corbett J.A. Heat shock inhibits cytokine-induced nitric oxide 0 synthase expression by rat and human islets. Endocrinology 139 (1998) 5050
5. Perdrizet G.A. Heat shock and tissue protection. New Horiz 3 (1995) 312
6. Hennige A.M., Lembert N., Wahl M.A., et al. Oxidative stress increases potassium efflux from pancreatic islets by depletion of intracellular calcium stores. Free Radic Res 33 (2000) 507
7. Bottino R., Balamurugan A.N., Tse H., et al. Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 53 (2004) 2559
8. Chandra J., Samali A., and Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29 (2000) 323
9. Janjic D., Andereggen E., Deng S., et al. Improved insulin secretion of cryopreserved human islets by antioxidant treatment. Pancreas 13 (1996) 166
10. Nissim I., States B., Hardy M., et al. Effect of glutamine on heat-shock-induced mRNA and stress proteins. J Cell Physiol 157 (1993) 313
11. Wischmeyer P.E., Musch M.W., Madonna M.B., et al. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol 272 (1997) G879
12. Amores-Sanchez M.I., and Medina M.A. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 67 (1999) 100
13. Caraher E.M., Conroy S.J., and Newsholme P. Evidence for enhanced rates of complement activation in serum from patients with newly diagnosed insulin-dependent diabetes mellitus exposed to rat islet cells and complement-dependent induction of islet cell apoptosis. J Endocrinol 162 (1999) 143
14. Van de Casteele M., Kefas B.A., Cai Y., et al. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem Biophys Res Commun 312 (2003) 937
15. Avila J., Barbaro B., Gangemi A., et al. Intra-ductal glutamine administration reduces oxidative injury during human pancreatic islet isolation. Am J Transplant 5 (2005) 2830