Evidence for enhanced rates of complement activation in serum from patients with newly diagnosed insulin-dependent diabetes mellitus exposed to rat islet cells and complement-dependent induction of islet cell apoptosis

Journal of Endocrinology

Volumn 162, Issue 1, 1999, Pages 143-153

  Caraher, E M ^a   Conroy, S J ^a   Newsholme, P ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3;

ANIMAL CELL; ANTIBODY RESPONSE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; COMPLEMENT ACTIVATION; DNA CLEAVAGE; HUMAN; IMMUNOSTIMULATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ADOLESCENT; ANIMALS; APOPTOSIS; AUTOANTIBODIES; CELLS, CULTURED; COMPLEMENT ACTIVATION; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; GLYCOPROTEINS; HUMANS; INTERLEUKIN-1; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR;

EID: 0032811803     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1620143     Document Type: Article

References (34)

1. Appels B, Burkart V, Kantwerk-Funke G, Funda J, Kolb-Bachofen V & Kolb H 1989 Spontaneous cytotoxicity of macrophages against cultured pancreatic islet cells. Journal of Immunology 142 3803-3808.
2. Atkinson MA & Maclaren NK 1994 The pathogenesis of insulin-dependent diabetes mellitus. New England Journal of Medicine 331 1428-1436.
3. Bach J-F 1988 Mechanisms of autoimmunity in insulin-dependent diabetes mellitus. Clinical and Experimental Immunology 72 1-8.
4. Bergamaschini L, Gardinali M, Poli M, Lorini, Bosi, Emanuele & Agostoni A 1991 Complent activation in diabetes mellitus. Journal of Clinical and Laboratory Immunology 35 121-127.
5. Bingley PJ, Christie MR, Bonifacio E, Bonafanti R, Shattock M, Fonte M-T, Bottazzo G-F & Gale EAM 1994 Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43 1304-1310.
6. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ, Rogge L, Pastore MR, Bognetti E, Bottazzo G-F, Gale EAM & Bosi E 1995 Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 38 816-822.
7. Bottazzo G-F, Dean BM, Gorsuch AN, Cudworth AG & Doniach D 1980 Complement-fixing islet-cell antibodies in type 1 diabetes. Possible monitors of active beta-cell damage. Lancet i 668-672.
8. Bottazzo G-F, Dean BM, McNally JM, MacKay EH, Swift PGF & Gamble DR 1985 In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitus. New England Journal of Medicine 313 353-360.
9. Castano L & Eisenbarth GS 1990 Type 1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annual Review of Immunology 8 647-679.
10. Cavender DE, Virji MA & Holze-Joost S 1986 Presence of complement-dependent cytotoxic activity against clonally-derived rat islet tumour cells in sera from type-1 (insulin-dependent) diabetic patients and control subjects. Diabetologia 19 616-622.
11. Conroy SJ, Abdel-Wahab YHA, Caraher EM, Byrne PM, Flatt PR & Newsholme P 1999 Evidence for complement-dependent and independent inhibition of insulin secretion from clonal β-cells incubated in the presence of newly diagnosed IDDM patient sera. Clinical Science (In press).
12. Corbett JA, Lancaster JR, Sweetland MA & McDaniel ML 1991 Interleukin-1β induced formation of EPR-detectable iron-nitrosyl complexes in Islets of Langerhans. Journal of Biological Chemistry 266 21351-21354.
13. Cotter TG & Martin SJ 1996 In Techniques in Apoptosis, pp 18-20. London: Portland Press.
14. Delaney CA, Green MHL, Lowe JE & Green IC 1993 Endogenous nitric oxide induced by interleukin-1β in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay. FEBS Letters 333 291-295.
15. Dobersen MJ, Scharff JE, Ginsberg-Fellner F & Notkins L 1980 Cytotoxic autoantibodies to beta-cells in the serum of patients with insulin dependent diabetes mellitus. New England Journal of Medicine 303 1493-1498.
16. Eisenbarth GS 1986 Type 1 diabetes mellitus: a chronic autoimmune disease. New England Journal of Medicine 315 1360-1368.
17. Eisenbarth GS, Morris MA & Scearce RM 1981 Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus. Journal of Clinical Investigation 67 403-408.
18. Eizink DL, Cagliero E, Bjorklund A & Welsh N 1992 Interleukin-1β induces the expression of an isoform of nitric oxide synthase in insulin-producing cells which is similar to that observed in activated macrophages. FEBS Letters 308 249-252.
19. Feshel K, Kroncke KD, Kolb H & Kolb-Bachofen V 1994 In situ nick-translation detects focal apoptosis in thymuses of glucocorticoid and lipopolysaccharide treated mice. Journal of Histochemistry and Cytochemistry 42 613-616.
20. Hull RN, Cherry WR & Weaver GW 1996 The origin and characteristics of a pig kidney cell strain LLC-PK. In Vitro 12 670-677.
21. 2+ channels exposed to serum from patients with type-1 diabetes. Science 261 86-90.
22. Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T-A, Nakamura M, Tatsumi H, Yamasaki Y, Kamada T & Taniguchi N 1995 Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 44 733-738.
23. Lorenzo A, Razzaboni B, Weir GC & Yankner BA 1994 Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus Nature 368 756-760.
24. McClenaghan NH, Barnett CR, O'Harte FPM & Flatt PR 1996 Characterization of a novel glucose-responsive insulin-secreting cell line BRIN BD11 produced by electrofusion. Diabetes 45 1132-1140.
25. Malaisse WJ, Sener A, Malaisse-Lagae F, Welsh M, Matthews DE, Bier DM & Hellerstrom C 1982 The stimulation-secretion coupling of amino acid-induced insulin release. Journal of Biological Chemistry 257 8731-8737.
26. O'Brien BA, Harmon BV, Cameron DP & Allan DJ 1996 Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. Journal of Pathology 178 176-181.
27. O'Brien BA, Harmon BV, Cameron DP & Allan DJ 1997 Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46 750-759.
28. Okamoto H 1992 Mechanisms of destruction of insulin-secretion cells. In Nutrient Regulation of Insulin Secretion, pp 387-406. Ed PR Flatt. London: Portland Press.
29. Rabinovitch A, Suarez-Pinzon WL, Shi Y, Morgan AR & Bleackley RC 1994 DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction. Diabetologia 37 733-738.
30. Radillo O, Nocera A, Leprini A, Barocci S, Mollnes TE, Pocecco M, Pausa M, Valente U, Betterle C & Tedesco F 1996 Complement-fixing islet cell antibodies in Type 1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic. Clinical Immunology and Immunopathology 79 217-223.
31. Rittenhouse HG, Oxender DL, Pek S & Ar D 1980 Complement-mediated cytotoxicity effects on pancreatic islets with sera from diabetic patients. Diabetes 29 317-322.
32. Schreck R, Meier B, Mannel DN, Droge W & Baeuerle PA 1992 Dithiocarbamates as potent inhibitors of nuclear factor κΒ activation in intact cells. Journal of Experimental Medicine 175 1181-1194.
33. Somoza N, Vargas F, Roura-Mir C, Vives-Pi M, Fernandez-Figueras MT, Ariza A, Gomis R, Bragado R, Marti M, Jaraquemada D & Pujol-Borrell R 1994 Pancreas in recent onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T-cell receptor Vβ usage and cytokine profile. Journal of Immunology 153 1360-1377.
34. Welsh N & Sandler S 1992 Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets. Biochemical and Biophysical Research Communications 182 333-340.