Final safety assessment of coal tar as used in cosmetics

International Journal of Toxicology

Volumn 27, Issue SUPPL. 2, 2008, Pages 1-24

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE; AROMATIC HYDROCARBON; BERNITER; BIOCIDE; CARBON; COAL TAR; COKE; COSMETIC; CRESOL; DERMATOLOGICAL AGENT; DRUG METABOLITE; HYDROCARBON; ISOQUINOLINE; NAPHTHALENE; ORNITHINE DECARBOXYLASE; OXYGEN; PENTRAX; PETROLATUM; PHENOL; PHOTOSENSITIZING AGENT; POLYTAR; SHAMPOO; SODIUM CHLORIDE; TERSA TAR; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; WATER; XYLENE; ZETAR EMULSION;

ADVERSE OUTCOME; AMES TEST; ANUS CANCER; ATOPIC DERMATITIS; BACTERIAL INFECTION; BASAL CELL CARCINOMA; BLISTER; BRAIN CORTEX; BRONCHOSPASM; BULLOUS PEMPHIGOID; CANCER EPIDEMIOLOGY; CANCER RISK; CARCINOGENICITY; CEREBELLUM; CHROMOSOME BREAKAGE; CHRONIC TOXICITY; COKING INDUSTRY; CONGENITAL DISORDER; CONTACT SENSITIVITY; CORPUS STRIATUM; DANDRUFF; DNA ADDUCT; DOSE RESPONSE; DRUG ABSORPTION; DRUG EXCRETION; DRUG MANUFACTURE; DRUG SYNTHESIS; EATING DISORDER; ECZEMA; EPITHELIUM TUMOR; ERYTHEMA; EXPERIMENTAL MOUSE; EXPERIMENTAL PIG; EXPERIMENTAL RAT; FLUID INTAKE; FOLLICULITIS; FOOD AND DRUG ADMINISTRATION; FORCED EXPIRATORY VOLUME; GENOTOXICITY; GUINEA PIG; HAIR GROWTH; HUMAN; LEYDIG CELL; LIVER TUMOR; LIVER WEIGHT; LONG TERM EXPOSURE; LUNG TUMOR; MALAISE; MELANOMA; MUTAGENICITY; NEURODERMATITIS; NEUROTOXICITY; NONHUMAN; ODOR; OVARY; PALATABILITY; PANCYTOPENIA; PATCH TEST; PHOTOSENSITIZATION; PHOTOTOXICITY; PRURITUS; PSORIASIS; RESPIRATORY TRACT DISEASE; REVIEW; RISK ASSESSMENT; SEBORRHEA; SIDE EFFECT; SISTER CHROMATID EXCHANGE; SKIN ABSORPTION; SKIN CANCER; SKIN DEFECT; SKIN DISCOLORATION; SKIN EDEMA; SKIN IRRITATION; SKINFOLD THICKNESS; SNEEZING; SPONTANEOUS ABORTION; SQUAMOUS CELL CARCINOMA; SURVIVAL; TABLET; TASTE; TERATOGENESIS; ULTRAVIOLET IRRADIATION; URINALYSIS; WEIGHT REDUCTION;

ANIMALS; COAL TAR; COSMETICS; FEMALE; HUMANS; TOXICITY TESTS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA; MAMMALIA; MUS; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 53149150567     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810802244405     Document Type: Review

References (156)

1. Alexander, J. O., and K. I. Macrosson. 1954. Squamous epithelioma probably due to tar ointment in a case with psoriasis. BMJ. 2:1089.
2. Arnold, W. P. 1997. Tar. Clin. Dermatol. 15:739-744.
3. Bacelar, J. 1932. Ovarian changes in rabbits painted with tar. Ann. Anat. Pathol. 9:565-568.
4. Berenblum, I. 1948. Liquor picis carbonis (BP), a carcinogenic agent. BMJ. 2:601.
5. Berne, B., and T. Fischer. 1987. The UV erythema action spectra of three coal tar preparations. Clin. Exp. Dermatol. 12:400-402.
6. Bhate, S. M., G. R. Sharpe, J. M. Marks, S. Shuster, and W. M. Ross. 1993. Prevalence of skin and other cancers in patients with psoriasis. Clin. Exp. Dermatol. 18:401-404.
7. Bickers, D. R., and A. Kappas. 1978. Human skin aryl hydrocarbon hydroxylase: Induction by coal tar. J. Clin. Invest. 62:1061-1068.
8. Bickers, D. R., D. Wroblewski, T. Dutta-Choudhury, et al. 1982. Induction of neonatal rat skin and liver aryl hydrocarbon hydroxylase by coal tar and its constituents. J. Invest. Dermatol. 78:227-229.
9. Bologa, M., A. Pastuszak, N. H. Shear, et al. 1992. Dermatologic drugs in pregnancy. Clin. Dermatol. 9:435-351.
10. Bos, R. P., and F. J. Jongeneelen.1988. Nonselective and selective methods for biological monitoring of exposure to coal-tar products. In: Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, ed. H. Bartsch, K. Hemminki, and I. K. O'Neill, 389-395. IARC Scientific Publications No. 89. Lyon, France: International Agency for Research on Cancer.
11. Budavari, S., ed. 1989. The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals, 11th ed., 2421. Rathway, NJ: Merck & Co., Inc.
12. Burden, A. D., H. Muston, and M. H. Beck. 1994. Intolerance and contact allergy to tar and dithranol in psoriasis. Contact Dermatitis 31:185-186.
13. Čern?́ková, M., H. Dubský, and J. Horáček. 1983. Detection of acridine in human urine after topical coal-tar treatment. J. Chromatog. 273:202-206.
14. Christie, G. S., and N. E. W. McCallum. 1958. The carcinogenicity of brown coal tar. Austral. J. Pharm. 39:116-118.
15. Clark, A. R., and E. F. Sheretz. 1998. The incidence of allergic contact dermatitis in patients with psoriasis vulgaris. Am. J. Contact Dermatitis 9:96-99.
16. Clonfero, E., D. Cottica, D. P. Venier, et al. 1987. Mutagenic activity and polycyclic aromatic hydrocarbon (PAH) levels in urine of humans. In: Occupational and Environmental Chemical Hazards, ed. V. Foa, E. A. Emmett, M. Maroni, and A. Colmbi, 438-443. Chichester, UK: Ellis Horwood Limited.
17. Clonfero, E., F. Jongeneelen, M. Zordan, et al. 1990. Biological monitoring of human exposure to coal tar. Urinary mutagenicity assays and analytical determination of polycyclic aromatic hydrocarbon metabolites in urine. In: Complex Mixtures and Cancer Risk, ed. H. Vainio, M. Sorsa, and A. J. McMichael, 215-222. IARC Scientific Publications No. 104. Lyon, France: International Agency for Research on Cancer.
18. Clonfero, E., M. Zordan, D. Cottica, et al. 1986. Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of humans exposed to therapeutic coal tar. Carcinogenesis 7:819-823.
19. Clonfero, E., M. Zordan, P. Venier, et al. 1989. Biological monitoring of human exposure to coal tar. Urinary excretion of total polycyclic aromatic hydrocarbons 1-hydroxypyrene and mutagens in psoriatic patients. Int. Arch. Occup. Environ. Health 61:363-368.
20. Committee of Revision of the United States Pharmacopeial Convention. 1995. The United States Pharmacopeia, 23rd ed., 413. Rockville, MD:United States Pharmacopeial Convention, Inc.
21. Conover, E. A., and W. F. Rayburn. 1992. Over-the-counter drugs during pregnancy. Drug Ther. ObGyn. 3:45-55.
22. 2
23. Culp, S. J., and F. A. Beland. 1994. Comparison of DNA adduct formation in mice fed coal tar or benzo[a]pyrene. Carcinogenesis 14:247-252.
24. Culp, S. J., D. W. Gaylor, W. G. Sheldon, et al. 1998. A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay. Carcinogenesis 19:117-124.
25. Cusano, F., M. Capozzi, and G. Errico. 1992. Allergic contact dermatitis from coal tar. Contact Dermatitis 27:51-52.
26. Das, M., P. Asokan, P. S. Don, et al. 1986. Carcinogen metabolism in human skin grafted onto athymic nude mice: A model system for the study of human skin carcinogenesis. Biochem. Biophys. Res. Commun. 138:33-39.
27. Das, M., D. R. Bickers, R. M. Santella, et al. 1985. Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice. J. Invest. Dermatol. 84:532-536.
28. Diette, K. M., R. W. Gange, R. S. Stern, et al. 1983. Coal tar phototoxicity: Kinetics and exposure parameters. J. Invest. Dermatol. 81:347-350.
29. Diette, K. M., R. W. Gange, R. S. Stern, et al. 1985. Coal tar phototoxicity: Characteristics of the smarting reaction. J. Invest. Dermatol. 84:268-271.
30. Durkin, W., N. Sun, J. Link, et al. 1978. Melanoma in a patient treated for psoriasis. South. Med. J. 71:732-733.
31. Environmental Protection Agency (EPA). 1994. Toxicological Profile for Polycyclic Hydrocarbons (PAHs). Washington, DC: Environmental Protection Agency:
32. European Economic Community. 1999. EEC Cosmetics Directive 76/768/EEC, as amended through the 26th Adapting Commission Directive 2002/34/EC, Annexes I-VII. Brussels: EEC. Available at http:dg3.eudra.org/F3/home.html.
33. Evelo, C. T. A., J. Atema, J. H. J. Copius-Peereboom, et al.1989. Liver damage after coal-tar treatment does not prevent induction of glutathione S-transferases in rat liver. Arch. Toxicol. Suppl. 13:112-116.
34. Everett, M. A., E. Daffer, and C. M. Coffey. 1961. Coal tar and ultraviolet light. Arch. Dermatol. 84:163-166.
35. Everett, M. A. and J. V. Miller. 1961. Coal tar and ultraviolet light. III. Cumulative effects. Arch. Dermatol. 84:937-940.
36. Food and Drug Administration (FDA). 1982. Advanced notice of proposed rule making, OTC drug products for the control of dandruff, seborrheic dermatitis and psoriasis. Federal Register 47:54646-54684.
37. FDA. 1986. Dandruff, seborrheic dermatitis and psoriasis drug products for over-the-counter human use; tentative final monograph. Federal Register 51:27346-27360. Compilation of OTC drug regulations.
38. FDA. 1991. Final monograph, dandruff, seborrheic dermatits and psoriasis drug products for over-the-counter human use. Federal Register 56:63554-63569.
39. FDA. 2001a. Letter from J. Woodcock to P. Gottesfeld. Re: Docket No. 99F-1210, Comments No. CP1, C1 and C2. January 24, 2001.
40. FDA. 2001b. Letter from D. E. Baker to P. Gottesfeld. Re: Docket No. 00F-1210, Comments No. CP1, C1 and C2. February 27, 2001.
41. FDA. 2002. Frequency of use of cosmetic ingredients. FDA database. Washington, DC: FDA.
42. Foreman, M. I., S. Picton, G. A. Lukowiecki, et al. 1979. The effect of topical crude coal tar treatment on unstimulated hairless hamster skin. Br. J. Dermatol. 100:707-715.
43. Franssen, M. E., G. J. van der Wilt, P. C. de Jong, et al. 1999. A retrospective study of the teratogenicity of dermatological coal tar products [letter]. Acta Dermatol. Venereol. 79:390-391.
44. Fysh, J. M., L. S. Andrews, L. R. Pohl, et al. 1980. Differing degrees of coal-tar shampoo-induced mutagenesis in the Salmonella/liver test system in vitro. Pharmacology 20:1-8.
45. Gennaro, A. R. 1990. Remington's Pharmaceutical Sciences, 18th ed., 764. Easton, PA: Mack Publishing Co.
46. Giles, A. S., A. Seidel, and D. H. Phillips. 1996. Covalent DNA adducts formed in mouse epidermis by benzo[g]chyrsene. Carcinogenesis 17:1331-1336.
47. Giles, A. S., A. Seidel, and D. H. Phillips. 1997. Covalent DNA adducts formed by benzo[c]chrysene fjord-region diol epoxides reacted with DNA and polynucleotides. Chem. Res. Toxicol. 10:1275-1284.
48. Godschalk, R. W., J. U. Ostertag, E. J. Moonen, et al. 1998. Aromatic DNA adducts in human white blood cells and skin after dermal application of coal tar. Cancer Epidemiol. Biomarkers Prev. 7:767-773.
49. Goeckerman, W. H. 1925. The treatment of psoriasis. Northwest Medicine XXIV (January-February):229-231.
50. Gonçalo, S., I. Sousa, and A. Moreno. 1984. Contact dermatitis to coal tar. Contact Dermatitis 10:57-58.
51. Gosselin, R. E., R. P. Smith, and H. C. Hodge. 1984. Clinical Toxicology of Commercial Products, 5th ed., II-191. Baltimore, MD: Williams & Wilkins.
52. Gottschalck, T. E., and G. N. McEwen Jr., eds. 2004. International Cosmetic Ingredient Dictionary and Handbook, 11th ed. Washington, DC: CTFA.
53. Gould, J. W., M. G. Mercurio, and C. A. Elmets. 1995. Cutaneous photosensitivity diseases induced by exogenous agents. J. Am. Acad. Dermatol. 33:551-573.
54. Granella, M., and E. Clonfero. 1992. Sensitivity of different bacterial assays in detecting mutagens in urine or humans exposed to polycyclic aromatic hydrocarbons. Mutat. Res. 268:131-137.
55. Grimmer, G. 1990. Reply to Jongaleenen Letter to the Editor. Cancer Lett. 51:175-179.
56. Grubler, M., R. Klein, and M. Foxx. 1970. Chemical standardization and quality assurance of whole crude coal tar U S P utilizing GLC procedures. J. Pharm. Sci. 59:830-834.
57. Hansen, A. M., O. M. Poulsen, and T. Menne. 1993. Longitudinal study of excretion of metabolites of polycyclic aromatic hydrocarbons in urine from two psoriatic patients. Acta Dermatol. Venereol. 73:188-190.
58. Hess, R. 1999. Safety assessment of refined coal tar used in rinse-off hair care products. J. Toxicol. Cutan. Ocular Toxicol. 18:161-166.
59. Hodgson, G. 1948. Epithelioma following the local treatment of prurius ani with liquor picis carbonis. Br. J. Dermatol. 60:282.
60. Hughes, N. C., W. Pfau, and A. Hewer. 1993. Covalent binding of polycyclic aromatic hydrocarbon component of coal tar to DNA in mouse skin. Carcinogenesis 14:135-144.
61. Hukkelhoven, M. W. A. C., L. W. M. Vromans, F. N. A. M. Van Pelt, et al. 1984. In vivo induction of aryl hydrocarbon hydroxylase in human scalp hair follicles by topical application of a commercial coal tar preparation. Cancer Lett. 23:135-143.
62. Ibbotson, S. H., S. C. Stenton, and N. B. Simpson. 1995. Acute severe bronchoconstriction precipitated by coal tar bandages. Clin. Exp. Dermatol. 20:58-59.
63. Illchyshyn, A., P. H. Carwright, and A. G. Smith. 1987. Contact sensitivity to newsprint: A rare manifestation of coal tar allergy. Contact Dermatits 17:52-53.
64. International Agency for Research on Cancer (IARC). 1985. Polynuclear aromatic hydrocarbons, Part 3, Risk of Chemicals of Humans, Industrial Exposures... Coal Gasification, Coke Production. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 34. Lyon, France: IARC.
65. Itchikawa, K., and S. M. Baum. 1925. The rapid production of cancer in rabbits by coal tar. J. Cancer Res. 9:85-104.
66. Jackson, E. M. 2003. Coal Tar: Use, genotoxicity, risk assessment and epidemiology. Presented to the Cosmetic Ingredient Review Expert Panel, February 6, 2003.2
67. Jemec, G. B. E., and A. Øserlind. 1994. Cancer in patients treated with coal tar: A long term follow up study. J. Eur. Acad. Dermatol. Venereol. 3:153-156.
68. Jacob J., H. Brune, G. Gettbarn, et al. 1989. Urinary and faecal excretion of pyrene and 1-hydroxypyrene by rats after oral, intraperitoneal, intratracheal and intrapulmonary application. Cancer Lett. 46:14-20.
69. Jones, S. K., R. M. Mackie, D. J. Hole, et al. 1985. Further evidence of the safety of tar in the management of psoriasis. Br. J. Dermatol. 113:97-101.
70. Jongeneelen, F. J., R. P. Bos, R. B. Anzion, et al. 1986. Biological monitoring of polycyclic aromatic hydrocarbons. Metabolites in urine. Scand. J. Work Environ. Health 12:137-143.
71. Jongeneelen, F. J., R. P. Bos, and P. T. Henderson. 1988. Metabolites of polycyclic aromatic hydrocarbons in urine of exposed workers. Toxicol. Environ. Chem. 16:295-307.
72. Jorstad, L. H. 1923. A study of the behavior of coal tar on tissues. Proc. Soc. Exp. Biol. Med. 21:67-70.
73. Jorstad, L. H. 1925. The behavior of coal tar in adult and embryonic tissue. J. Cancer Res. 9:232-253.
74. Kaaber, K. 1976. Occurrence of malignant neoplasms in patients with atopic dermatitis. Acta Dermatovener (Stockholm) 56:445-447.
75. Kaidbey, K. H., and A. M. Kligman. 1974a. A human model of coal tar acne. Arch. Dermatol. 109:212-215.
76. Kaidbey, K. H., and A. M. Kligman. 1974b. Topical photosensitizers. Influence of vehicles on penetration. Arch. Dermatol. 110:868-870.
77. Kaidbey, K. H., and A. M. Kligman. 1975. Further studies of photoaugmentation in humans: Phototoxic reactions. J. Invest. Dermatol. 65:572-575.
78. Kaidbey, K. H., and A. M. Kligman. 1977. Clinical and histological study of coal tar phototoxicity in humans. Arch. Dermatol. 113:592-595.
79. Kirby, P. E. 2003. Review of the genotoxicity of Coal Tar. Report to Jackson Research Associates, Inc. Sumner, WA. January 24, 2003.2
80. Kligman, A. M., and L. H. Kligman. 1994. Carcinogens show comedogenic activity: A potential animal screen for tumorigenic substances. Cancer Lett. 87:171-178.
81. Kochevar, I. E., R. B. Armstrong, J. Einbinder, et al. 1982. Coal tar phototoxicity: Active compounds and action spectra. Photochem. Photobiol. 36(1): 65-70.
82. Koerber, W. A., Jr., N. M. Price, and W. Watson. 1978. Coexistent psoriasis and bullous pemphigoid: A report of six cases. Arch. Dermatol. 114:1643-1646.
83. Koganti, A., R. Siingh, K. Rozett, et al. 2000. 7H-Benzo(c)fluorene: A major DNA adduct forming component of coal tar. Carcinogenesis 21:1601-1609.
84. Kokkini, G., and H. Giotaki. 1984. Pancytopenia associated with coal treatment. Haematologica 69:454-457.
85. Koppers, Company, Inc. (no date). Ames Salmonella/microsome assay of seven coal tar distillate fractions with attachments. NTIS Report No. OTS0516153.
86. Kosuge, T., H. Zenda, N. Nukaya, et al. 1982. Isolation and structural determination of mutagenic substances in coal tar. Chem. Pharm. Bull. 30:1535-1538.
87. Kroon, S. 1983. Standard photopatch testing with Waxtar, para-aminobenzoic acid, potassium dichromate and basalm of Peru. Contact Dermatitis 9:5-9
88. Landro, A. D., R. Valsecchi, and T. Cainelli. 1992. Contact allergy to dithranol. Contact Dermatitis 26:49-50.
89. Larko, O., and G. Swanbeck. 1982. Is UVB treatment of psoriasis safe? A study of extensively UVB treated psoriasis patients compared with a matched control group. Acta Dermatovener (Stockholm) 62:507-512.
90. L'Epee, P., H. J. Lazarini, and J. Doignon. 1983. Encyclopaedia of Occupational Health and Safety, Vol. 2, 2147-2149.
91. Lerner, M. R., and A. B. Lerner. 1960. Dermatologic Medications, 2nd ed., 169-173. Chicago: Year Book Publishers.
92. Lewis, R. J., Sr. 1993. Hazardous Chemicals Desk Reference, 3rd ed., 341-342. New York: Van Nostrand Reinhold.
93. Lin, A. N., and K. Moses. 1985. Tar revisited. Int. J. Dermatol. 24:216-218.
94. Litofsky, I. B. 1999. A review of analytical methodology for the determination of polycyclic aromatic hydrocarbons in coal tar products. J. Cutan. Ocular Toxicol. 18:151-156.
95. Lowe, N. J., J. Breeding, and M. S. Wortzman. 1982. The pharmacological variability of crude coal tar. Br. J. Dermatol. 107:475-479.
96. Maughan, W. Z., S. A. Muller, H. O. Perry, et al. 1980. Incidence of skin cancers in patients with atopic dermatitis treated with coal tar. A 25-year follow-up study. J. Am. Acad. Dermatol. 3:612-615.
97. McGarry, G. W., and J. R. Robertson. 1989. Scrotal carcinoma following prolonged use of crude coal tar ointment. Br. J. Urol. 63:211.
98. Merk, H. F., H. Mukhtar, I. Kaufmann, et al. 1987. Human hair follicle benzo[a]pyrene and benzo[a]pyrene 7,8-diol metabolism: Effect of exposure to a coal-tar containing shampoo. J. Invest. Dermatol. 88:71-76.
99. Mills, O. H., M. Porte, and A. M. Kligman. 1978. Enhancement of comedogenic substances by ultraviolet radiation. Br. J. Dermatol. 98:145-150.
100. Ministry of Health, Labor, and Welfare (MHLW). 2001a. Unofficial translation of MHW Ordinance No. 331, Attached Table 1 [Negative List]. Ministry of Health, Labor and Welfare, Pharmaceutical and Medical Safety Bureau, Inspection and Guidance Division 2-2 1-chome, Kasumigaseki, Chiyoda-ku, Tokyo 100 - 8045, Japan.
101. MHLW. 2001b. Unofficial translation of MHW Ordinance No. 331, Attached Table 2 [Restricted List]. Ministry of Health, Labor, and Welfare, Pharmaceutical and Medical Safety Bureau, Inspection and Guidance Division 2-2 1-chome, Kasumigaseki, Chiyoda-ku, Tokyo 100-8045, Japan.
102. Mukhtar, H., P. Asokan, M. Das, et al. 1986b. Benzo(a)pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of SENCAR mice following topical application of crude coal tar. Cancer Lett. 33: 287-294.
103. Mukhtar, H., and D. R. Bickers. 1982. Evidence that coal tar is a mixed inducer of microsomal drug-metabolizing enzymes. Toxicol. Lett. 11:221-227.
104. Mukhtar, H., M. Das, and D. R. Bickers. 1986c. Skin tumor initiating activity of therapeutic crude coal tar as compared to other polycylic aromatic hydrocarbons in SENCAR mice. Cancer Lett. 31:147-151.
105. Mukhtar, H., B. J. DelTito Jr., P. M. Matgouranis, et al. 1986a. Additive effects of ultraviolet B and crude coal tar on cutaneous carcinogen metabolism: Possible relevance to the tumorigenicity of the Goeckerman regimen. J. Invest. Dermatol. 87:348-353.
106. Murphy, J. B., and E. Sturm. 1925. Primary lung tumors in mice following the cutaneous application of coal tar. J. Exp. Med. 42:693-700.
107. OEHHA 2003. State of California Environmental Protection Agency Office of Environmental Health Hazard Assessment (OEHHA) Safe Drinking Water and Toxic Enforcement Act of 1986: Chemicals known to the state to cause cancer or reproductive toxicity, July 11, 2003. http://www.oehha.org/prop65/prop65 list/files/71103LISTA.pdf.
108. Paleologo, M., F. J. van Schooten, S. Pavanello, et al. 1992. Detection of benzo[a]pyrene-diol-epoxide-DNA adducts in white blood cells of psoriatic patients treated with coal tar. Mutat. Res. 281:11-16.
109. Pavanello, S., D. Favretto, F. Brugnone, et al. 1999. HPLC/fluorescece determination of anti-BPDE-DNA adducts in mononuclear white blood cells from PAH-exposed humans. Carcinogenesis 20:431-435.
110. Pavanello, S., and A. G. Levis. 1992. Coal tar therapy does not influence in vitro benzo[a]pyrene metabolism and DNA adduct formation in peripheral blood lymphocytes of psoriatic patients. Carcinogenesis 13: 1569-1573.
111. Pavanello, S., and A. G. Levis. 1994. Human peripheral blood lymphocytes as a cell model to evaluate the genotoxic effect of coal tar treatment. Environ. Health Perspect. 102:95-99.
112. Perov, O. V. 1972. Changes in antioxidative activity of cells and functions of the nucleus by the action of subtoxic doses of phenol-pyridine mixtures from coal tar. Bull. Exp. Biol. Med. 73:267-270.
113. Person, J. R., and R. S. Rogers III. 1976. Bullous pemphigoid and psoriasis: Does subclinical bullous pemphigoid exist? Br. J. Dermatol. 95: 535-540.
114. 32P-labelled nucleoside 3′,5′-biphosphate adducts by HPLC. IARC Scientific Publication No. 124, pp. 233-242.
115. Phillips, D. H., and A. J. Alldrick. 1994. Tumorigenicity of a combination of psoriasis therapies. Br. J. Cancer 69:1043-1045.
116. Pickering, R. W. 1999. A toxicological review of polycyclic aromatic hydrocarbons. J. Cutan. Ocular Toxicol. 18:101-135.
117. Pinsky, C., and R. Bose. 1988. Pyridine and other coal tar constituents as free radical-generating environmental neurotoxicants. Mol. Cell. Biochem. 84:217-222.
118. Pion, I. A., K. L. Koenig, and H. W. Lim. 1995. Is dermtologic usage of coal tar carcinogenic? Dermatol. Surg. 21:227-231.
119. Pittelkow, M. R., H. O. Perry, and S. A. Muller. 1981. Skin cancer in patients with psoriasis treated with coal tar. A 25-year follow-up study. Arch. Dermatol. 117:465-468.
120. Registry of Toxic Effects of Chemical Substances (RTECS). 2001. Coal tar entries. RTECS database. Bethesda, MD: National Library of Medicine.
121. Riboldi, A., P. D. Pigatto, M. O. Innocenti, et al. 1986. Contact dermatitis to coal tar in psoraisis. Contact Dermatitis 14:187-188.
122. Ritschel, W. A., P. E. Ring, and E. G. Siegel. 1975. Influence of coal tar on hair growth in rabbits. Sci. Pharm. 43:73-80.
123. Santella, R. M., M. G. Nunes, R. Blaskovic, et al. 1994. Quantitation of polycyclic aromatic hydrocarbons 1-hydroxypyrene, and mutagenicity in urine of coal tar-treated psoriasis patients and untreated volunteers. Cancer Epidem. Biomarkers Prevent. 3:137-140.
124. Santella, R. M., F. P. Perera, T. L. Young, et al. 1995. Polycyclic aromatic hydrocarbon-DNA and protein adducts in coal tar treated patients and controls and their relationship to glutathione S-transferase genotype. Mutat. Res. 334:117-124.
125. Saperstein, M. D., and L. A. Wheeler. 1979. Mutagenicity of coal tar preparations used in the treatment of psoriasis. Toxicol. Lett. 3:325-329.
126. Sarkany, I., and P. M. Gaylarde. 1976. Effect of coal tar fractions on guinea-pig and human skin. Clin. Exp. Dermatol. 1:51-58.
127. Sarto, F., M. Zordan, R. Tomanin, et al. 1989. Chromosomal alterations in peripheral blood lymphocytes, urinary mutagenicity and excretion of polycyclic aromatic hydrocarbons in six psoriatic patients undergoing coal tar therapy. Carcinogenesis 10:329-334.
128. Schoket, B., A. Hewer, P. L. Grover, et al. 1988a. Covalent binding of components of coal tar, creosote and bitumen to the DNA of the skin and lungs of mice following topical application. Carcinogenesis 9:1253-1258.
129. Schoket, B., A. Hewer, P. L. Grover, et al. 1988b. Formation of DNA adducts in human skin maintained in short-term organ culture and treated with coal-tar, creosote or bitumen. Int. J. Cancer 42:622-626.
130. Schoket, B., I. Horkay, Á. Kósa, et al. 1990. Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture, and in mouse skin and lung following topical application of coal-tar and juniper tar. J. Invest. Dermatol. 94:241-246.
131. Seelig, M. G., and Z. K. Cooper. 1933. Light and tar cancer: An experimental study with a critical review of the literature on light as a carcinogenic factor. Surg. Gynecol. Obstet. 56:752-761.
132. Shabad, L. M. 1927. Coal tar as a carcinogen when applied to the rectum of white mice. Vestnik Rentgenologii i Radiologii 5:171-179.
133. Simon, C. R., and R. Brandt. 1953. Eczematous hypersensitivity to coal tar. AMA Arch. Dermatol. Syphilol. 67:584-586.
134. Simonds, J. P., and J. S. Curtis. 1935. Lesions induced in the lungs by intravenous injection of tar. Arch. Pathol. 19:287-302.
135. Starke, J. C., and O. F. Jillson. 1961. Photosensitization to coal tar. A cause of psoriatic erythroderma. Arch. Dermatol. 84:935-936.
136. Stone, O. J., and C. J. Willis. 1969. The effect of tar on infection. Toxicol. Appl. Pharmacol. 15:677-678.
137. Storer, J. S., I. DeLeon, L. E. Millikan, et al. 1984. Human absorption of crude coal tar products. Arch. Dermatol. 120:874-877.
138. Tenant, R. W., B. H. Margolin, M. D. Sheby, et al. 1987. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236:933-941.
139. Thein, N., P. Moller, H. Amtoft, et al. 2000. A strong genotoxic effect in mouse skin of a single painting of coal tar in hairless mice and in Muta™ Mouse. Mutat. Res. 468:117-124.
140. Van Cantfort, J., T. Lorand, J. E. Gielen, et al. 1986. Human epidermal blister: A convenient tissue for toxicological and genetic studies of benzo(a)pyrene metabolism. Arch. Dermatol. Res. 278:324-328.
141. VanRooij, J. G. M., J. H. C. De Roos, M. M. Bodelier-Bade, et al. 1993. Absorption of polycyclic aromatic hydrocarbons through human skin: Differences between anatomical sites and individuals. J. Toxicol. Environ. Health 38:355-368.
142. VanRooij, J. G. M., E. Vinke, J. De Lange, et al. 1995. Dermal absorption of polycyclic aromatic hydrocarbons in the blood-perfused pig ear. J. Appl. Toxicol. 15:193-200.
143. van Schooten, F.-J., E. J. C. Moonen, E. Rhijnsburger, et al. 1994. Dermal uptake of polycyclic aromatic hydrocarbons after hairwash with coal-tar shampoo. Lancet 344:1505-1506.
144. Viau, C., and A. Vyskocil. 1995. Patterns of 1-hydroxypyrene excretion in volunteers exposed to pyrene by the dermal route. Sci. Total Environ. 163:187-190.
145. Vlajinac, H. D., B. J. Adanja, Z. F. Lazar, et al. 2000. Risk factors for basal cell carcinoma. Acta Oncol. 39:611-616.
146. Warshawsky, D., W. Barkley, and E. Bingham. 1993. Factors affecting carcinogenic potential of mixtures. Fundam. Appl. Toxicol. 20: 376-382.
147. Watson, A. F. 1935. Comparative studies on carcinogenesis in rats. Am. J. Cancer 25:753-762.
148. Watson, A. F., and E. Mellanby. 1930. Tar cancer in mice: I. The technique of the comparative experiment. Br. J. Exp. Pathol. 11:267-281.
149. Weyand, E. H., Y. Wu, S. Patel, et al. 1991. Urinary excretion and DNA binding of coal tar components in B6C3F1 mice following ingestion. Chem. Res. Toxicol. 4:466-473.
150. Wheeler, L. A., M. D. Saperstein, and N. J. Lowe. 1981. Mutagenicity of urine from psoriatic patients undergoing treatment with coal tar and ultraviolet light. J. Invest. Dermatol. 77:181-185.
151. Wilkinson, J., and R. Moore, eds. 1982. Harry's Cosmetology, 7th ed., 499. New York: Chemical Publishing.
152. Wright, C. W., D. W. Later, R. A. Pelroy, et al. 1985. Comparative chemical and biological analysis of coal tar-based therapeutic agents to other coal-derived materials. J. Appl. Toxicol. 5:80-88.
153. Wright, M. C., A. Kaufhold, F. Hevert, et al. 1992. Studies on the possible nephrotoxicity of a coal tar-containing dermatic. Hautarzt 43:483-486.
154. Yamagiwa, K., and K. Ichikawa. 1917. Experimental study of the pathogenesis of carcinoma. J. Cancer Res. 3:1-29.
155. Yoshikawa, K. 1996. Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens. Environ. Health Perspect. 104:40-46.
156. 32P postlabeling. Skin Pharmacol. 3:171-179.