Synthesis and characterization of 4′-bromomethyl-2-(N-trityl-1H- tetrazol-5-yl) biphenyl

Synthetic Communications

Volumn 38, Issue 20, 2008, Pages 3577-3581

  Wang, Guo Xi ^a   Sun, Bao Ping ^a   Ru, Zong Ling ^a  

^a ANYANG INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Angiotensin II; Free radical bromination; Synthesis; Tetrazole ring; Trityl protection

Indexed keywords

2,2' AZOISOBUTYRONITRILE; 4' BROMOMETHYL 2 (N TRITYL 1H TETRAZOL 5 YL)BIPHENYL; 4' METHYL 2 (1H TETRAZOL 5 YL)BIPHENYL; 4' METHYL 2 (N TRITYL 1H TETRAZOL 5 YL)BIPHENYL; AMMONIUM CHLORIDE; AZIDE; BIPHENYL DERIVATIVE; BUTYRONITRILE; CYCLOHEXANE; N BROMOSUCCINIMIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AUTOCLAVE; BROMINATION; CATALYSIS; CATALYST; CHEMICAL REACTION; SYNTHESIS;

EID: 53149123271     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910802228495     Document Type: Article

References (8)

1. Miroslav, V.; Martin, P.; Heinrich, B.; Silvo, Z. A process for the preparation of Sartan derivatives and intermediates useful in such process. EP 1764365, 2007.
2. Demko, Z. P.; Sharpless, K. B. Preparation of 5-substituted 1H-tetrazoles from nitriles in water. J. Org. Chem. 2001, 66, 7945-7950.
3. Markham, A.; Goa, K. L. Valsartan: A review of its pharmacology and therapeutic use in essential hypertension. Drugs 1997, 54(2), 299-311.
4. Galante, R. J.; Somerville, N. J. Method of synthesizing sterically hindered 5-substituted-1H-tetrazoles from nitriles using a Lewis acid and an azide. US Patent 5502191, 1996.
5. Chao, S. J.; Hui, X. P.; Li, S.; Qiu, Z. Z.; Xu, P. F.; Zhang, Z. Y.; Wang, Q.; Guan, Z. W. Synthesis and antibacterial activities of novel biphenyltetrazole derivatives bearing 1,3,4-oxadiazole. J. Chin. Chem. Soc.-Taip. 2005, 52(3), 539-544.
6. Silvo, Z.; Anica, P.; Rok, Z. A process for the synthesis of valsartan. EP 1661891, 2006.
7. Duncia, J. V.; Pierce, M. E.; Santella, J. B. Three synthetic routes to a sterically hindered tetrazole: A new one-step mild conversion of an amide into a tetrazole. J. Org. Chem. 1991, 56(7), 2395-2400.
8. Aldrich, P. E.; Pierce, M. E.; Duncia, J. J. V. Preparation of 5-(2-biphenylyl)-tetrazole derivatives as intermediates for antihypertensives. EP 291969, 1988.