Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21

Journal of Protein Chemistry

Volumn 18, Issue 8, 1999, Pages 875-879

  Chie, Lyndon ^a,b   Chen, James M ^c   Friedman, Fred K ^d   Chung, Denise L ^b   Amar, Shazia ^a   Michl, Josef ^e   Yamaizumi, Z ^f   Brandt Rauf, Paul W ^g   Pincus, Matthew R ^a,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b LONG ISLAND UNIVERSITY   (United States)

^c PFIZER INC   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e SUNY DOWNSTATE MEDICAL CENTER   (United States)

^f CANCER INSTITUTE   (Japan)

^g Columbia Coll of Phys and Surgeons ^*  (United States)

Author keywords

Effector domain; Inhibitory peptides; Oocyte maturation; Ras p21 SOS complex; Signal transduction

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; PROTEIN KINASE; PROTEIN P21; RAS PROTEIN; SYNTHETIC PEPTIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE OVEREXPRESSION; MOLECULAR DYNAMICS; NONHUMAN; ONCOGENE; ONCOGENE RAS; OOCYTE MATURATION; PEPTIDE SYNTHESIS; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 53149085963     PISSN: 02778033     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020683330019     Document Type: Article

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