Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation

Journal of Applied Physiology

Volumn 105, Issue 3, 2008, Pages 825-831

  Amati, Francesca ^a   Dubé, John J ^b   Shay, Chris ^c   Goodpaster, Bret H ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Aging; Exercise economy; Gross efficiency

Indexed keywords

AGED; ARTICLE; BODY FAT; CONTROLLED STUDY; CYCLING; DIET; ECONOMIC ASPECT; ENERGY EXPENDITURE; ERGOMETRY; EXERCISE; FEMALE; GERIATRIC PATIENT; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METABOLISM; OBESITY; OXIDATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PRODUCTIVITY; SITTING; WEIGHT REDUCTION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DIET THERAPY; ENERGY METABOLISM; EXERCISE TEST; FITNESS; KINESIOTHERAPY; LIPID METABOLISM; LOW CALORY DIET; MULTIMODALITY CANCER THERAPY; MUSCLE CONTRACTION; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; TREATMENT OUTCOME;

AGED; COMBINED MODALITY THERAPY; DIET, REDUCING; ENERGY METABOLISM; EXERCISE TEST; EXERCISE THERAPY; FEMALE; HUMANS; LIPID METABOLISM; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; OBESITY; OVERWEIGHT; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PHYSICAL FITNESS; PILOT PROJECTS; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 53049098895     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.90384.2008     Document Type: Article

References (38)

1. Adams WC. Influence of age, sex, and body weight on the energy expenditure of bicycle riding. J Appl Physiol 22: 539-545, 1967.
2. Anton-Kuchly B, Roger P, Varene P. Determinants of increased energy cost of submaximal exercise in obese subjects. J Appl Physiol 56: 18-23, 1984.
3. Astrand I. Aerobic work capacity in men and women with special reference to age. Acta Physiol Scand Suppl 49: 1-92, 1960.
4. 2 during steady-state cycling. Med Sci Sports Exerc 25: 1031-1037, 1993.
5. Boon H, Jonkers RA, Koopman R, Blaak EE, Saris WH, Wagenmakers AJ, Van Loon LJ. Substrate source use in older, trained males after decades of endurance training. Med Sci Sports Exerc 39: 2160-2170, 2007.
6. Brouwer E. On simple formulae for calculating the heat expenditure and the quantities of carbohydrate and fat oxidized in metabolism of men and animals, from gaseous exchange (oxygen intake and carbonic acid output) and urine-N. Acta Physiol Pharmacol Neerl 6: 795-802, 1957.
7. Chen KY, Acra SA, Donahue CL, Sun M, Buchowski MS. Efficiency of walking and stepping: relationship to body fatness. Obes Res 12: 982-989, 2004.
8. Coyle EF, Sidossis LS, Horowitz JF, Beltz JD. Cycling efficiency is related to the percentage of type I muscle fibers. Med Sci Sports Exerc 24: 782-788, 1992.
9. Dube JJ, Amati F, Stefanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH. Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol Endocrinol Metab 294: E882-E888, 2008.
10. Elia M, Ritz P, Stubbs RJ. Total energy expenditure in the elderly. Eur J Clin Nutr 54, Suppl 3: S92-S103, 2000.
11. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55: 628-634, 1983.
12. Friedlander AL, Jacobs KA, Fattor JA, Horning MA, Hagobian TA, Bauer TA, Wolfel EE, Brooks GA. Contributions of working muscle to whole body lipid metabolism are altered by exercise intensity and training. Am J Physiol Endocrinol Metab 292: E107-E116, 2007.
13. Gaesser GA, Brooks GA. Muscular efficiency during steady-rate exercise: effects of speed and work rate. J Appl Physiol 38: 1132-1139, 1975.
14. Gissane C, Corrigan DL, White JA. Gross efficiency responses to exercise conditioning in adult males of various ages. J Sports Sci 9: 383-391, 1991.
15. Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 52: 2191-2197, 2003.
16. Goodpaster BH, Wolfe RR, Kelley DE. Effects of obesity on substrate utilization during exercise. Obes Res 10: 575-584, 2002.
17. Guesbeck NR, Hickey MS, MacDonald KG, Pories WJ, Harper I, Ravussin E, Dohm GL, Houmard JA. Substrate utilization during exercise in formerly morbidly obese women. J Appl Physiol 90: 1007-1012, 2001.
18. Henriksson J. Training induced adaptation of skeletal muscle and metabolism during submaximal exercise. J Physiol 270: 661-675, 1977.
19. Horowitz JF, Klein S. Lipid metabolism during endurance exercise. Am J Clin Nutr 72: 558S-563S, 2000.
20. Kamon E, Metz KF, Pandolf KB. Climbing and cycling with additional weights on the extremities. J Appl Physiol 35: 367-370, 1973.
21. Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol Endocrinol Metab 277: E1130 -E1141, 1999.
22. Lafortuna CL, Proietti M, Agosti F, Sartorio A. The energy cost of cycling in young obese women. Eur J Appl Physiol 97: 16-25, 2006.
23. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 332: 621-628, 1995.
24. Martin WH 3rd, Dalsky GP, Hurley BF, Matthews DE, Bier DM, Hagberg JM, Rogers MA, King DS, Holloszy JO. Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. Am J Physiol Endocrinol Metab 265: E708-E714, 1993.
25. Menshikova EV, Ritov VB, Fairfull L, Ferrell RE, Kelley DE, Goodpaster BH. Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci 61: 534 -540, 2006.
26. Moseley L, Jeukendrup AE. The reliability of cycling efficiency. Med Sci Sports Exerc 33: 621-627, 2001.
27. Nicklas BJ, Rogus EM, Goldberg AP. Exercise blunts declines in lipolysis and fat oxidation after dietary-induced weight loss in obese older women. Am J Physiol Endocrinol Metab 273: E149-E155, 1997.
28. Peronnet F, Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16: 23-29, 1991.
29. Poole DC, Henson LC. Effect of acute caloric restriction on work efficiency. Am J Clin Nutr 47: 15-18, 1988.
30. Poulin MJ, Paterson DH, Govindasamy D, Cunningham DA. Endurance training of older men: responses to submaximal exercise. J Appl Physiol 73: 452-457, 1992.
31. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster BH. Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab 287: E857-E862, 2004.
32. Ravussin E, Burnand B, Schutz Y, Jequier E. Energy expenditure before and during energy restriction in obese patients. Am J Clin Nutr 41: 753-759, 1985.
33. Ravussin E, Burnand B, Schutz Y, Jequier E. Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects. Am J Clin Nutr 35: 566-573, 1982.
34. Rosenbaum M, Vandenborne K, Goldsmith R, Simoneau JA, Heymsfield S, Joanisse DR, Hirsch J, Murphy E, Matthews D, Segal KR, Leibel RL. Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol 285: R183-R192, 2003.
35. Starling RD. Energy expenditure and aging: effects of physical activity. Int J Sport Nutr Exerc Metab 11, Suppl: S208-S217, 2001.
36. Trappe SW, Costill DL, Vukovich MD, Jones J, Melham T. Aging among elite distance runners: a 22-yr longitudinal study. J Appl Physiol 80: 285-290, 1996.
37. van Aggel-Leijssen DP, Saris WH, Hul GB, van Baak MA. Short-term effects of weight loss with or without low-intensity exercise training on fat metabolism in obese men. Am J Clin Nutr 73: 523-531, 2001.
38. Woo JS, Derleth C, Stratton JR, Levy WC. The influence of age, gender, and training on exercise efficiency. J Am Coll Cardiol 47: 1049-1057, 2006.