Serial coupling of reversed-phase and hydrophilic interaction liquid chromatography to broaden the elution window for the analysis of pharmaceutical compounds

Journal of Chromatography A

Volumn 1208, Issue 1-2, 2008, Pages 90-94

  Louw, Stefan ^a   Pereira, Alberto S ^a   Lynen, Frédéric ^a   Hanna Brown, Melissa ^b   Sandra, Pat ^a  

^a GHENT UNIVERSITY   (Belgium)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Hydrophilic interaction; Liquid chromatography; Pharmaceutical analysis; Reversed phase; Serial coupling

Indexed keywords

ACETONITRILE; ARSENIC COMPOUNDS; BODY FLUIDS; CHEMOTHERAPY; CHLORINE COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; COLUMNS (STRUCTURAL); CONCENTRATION (PROCESS); DRUG DELIVERY; DRUG DOSAGE; DRUG INTERACTIONS; FLOW INTERACTIONS; HYDROPHILICITY; LIQUID PHASE EPITAXY; WATER ANALYSIS; WATER CONTENT;

DRUG DISCOVERIES; HIGH WATER CONTENT; HYDROPHILIC INTERACTION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY; MAKE-UP FLOW; MOBILE PHASE; PHARMACEUTICAL ANALYSIS; PHARMACEUTICAL COMPOUNDS; REVERSED-PHASE; REVERSED-PHASE LIQUID CHROMATOGRAPHY; SECOND-DIMENSION COLUMN; SERIAL COUPLING;

LIQUID CHROMATOGRAPHY;

ACETONITRILE;

ARTICLE; DRUG INDUSTRY; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; WATER CONTENT;

AMINOPYRIDINES; CARBOHYDRATES; CHROMATOGRAPHY, LIQUID; PHARMACEUTICAL PREPARATIONS; SULFONAMIDES;

EID: 53049098566     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.08.058     Document Type: Article

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