Effect of antiepileptic drugs on oral contraceptives

American Family Physician

Volumn 78, Issue 5, 2008, Pages 634-635

  Carl, Jenny S ^a   Weaver, Sally P ^a   Tweed, Elizabeth ^b   Edgerton, Lisa ^c  

^a Waco Family Medicine Residency Program   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c NEW HANOVER REGIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CYTOCHROME P450; ESTROGEN; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; GABAPENTIN; GESTAGEN; LAMOTRIGINE; MEDROXYPROGESTERONE ACETATE; ORAL CONTRACEPTIVE AGENT; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TIAGABINE; TOPIRAMATE; VALPROATE SEMISODIUM; VALPROIC ACID; ZONISAMIDE;

BIPOLAR DISORDER; BLEEDING; CHRONIC PAIN; CONDOM; DRUG EFFICACY; EVIDENCE BASED MEDICINE; FETUS DISEASE; HEADACHE; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; MIGRAINE; MOOD DISORDER; NEURAL TUBE DEFECT; PREGNANCY RATE; RISK; SEIZURE; SHORT SURVEY; UNPLANNED PREGNANCY; ARTICLE; DRUG ANTAGONISM; FEMALE; PREGNANCY;

ANTICONVULSANTS; CONTRACEPTIVES, ORAL; FEMALE; HUMANS; PREGNANCY;

EID: 53049097772     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (18)

1. Back DJ, Bates M, Bowden A, et al. The interaction of phenobarbital and other anticonvulsants with oral contraceptive therapy. Contraception. 1980;22(5):495-503. (Pubitemid 11213680)
2. Sonnen AEH. Sodium valproate and the pill. In: Epilepsy International Symposium, Akimoto H, eds. Advances in Epileptology: The XIIIth Epilepsy International Symposium. New York, NY: Raven Press, 1982: 429-432.
3. Crawford P, Chadwick DJ, Martin C, Tjia J, Back DJ, Orme M. The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids. Br J Clin Pharmacol. 1990;30(6):892-896.
4. Saano V, Glue P, Banfield CR, et al. Effects of felbamate on the pharmacokinetics of low-dose combination oral contraceptive. Clin Pharmocal Ther. 1995;58(5):523-531.
5. Klosterkov Jensen P, Saano V, et al. Possible interaction between oxcarbazepine and an oral contraceptive. Epilepsia. 1992;33(6):1149-1152. (Pubitemid 23005279)
6. Fattore C, Cipolla G, Gatti G, et al. Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women. Epilepsia. 1999;40 (6):783-787. (Pubitemid 29260720)
7. Rosenfeld WE, Doose DR, Walker SA, Nayak RK. Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. Epilepsia. 1997;38(3):317-323. (Pubitemid 27147645)
8. Crawford P, Chadwick D, Cleland P, et al. The lack of effect of sodium valproate on the pharmacokinetics of oral contraceptive steroids. Contraception. 1986;33(1):23-29. (Pubitemid 16133449)
9. Eldon MA, Underwood BA, Randinitis EJ, Sedman AJ. Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol. Neurology. 1998;50(4):1146-1148. (Pubitemid 28212855)
10. Holdich T, Whiteman P, Orme M, Back D, Ward S. Effect of lamotrigine on the pharmacology of the combined oral contraceptive pill. 19th International Epilepsy Congress. Rio de Janeiro, Brazil; October 14-19, 1991. Epilepsia. 1991;32(suppl 1):96.
11. Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol. 2006;61(2):191-199. (Pubitemid 43382612)
12. Giuliano RA, Hiersemenzel R, Baltes E, et al. Influence of a new antiepileptic drug (levetiracetam) on the pharmacokinetics and pharmacodynamics of oral contraceptives. 2nd Congress of Epileptology. The Hague, Netherlands; September 1-5, 1996. Epilepsia. 1996;37(suppl 4):90.
13. Ragueneau-Majlessi I, Levy RH, Janik F. Levetiracetam does not alter the pharmacokinetics of an oral contraceptive in healthy women. Epilepsia. 2002;43(7):697-702. (Pubitemid 34774250)
14. Mengel HB, Houston A, Back DJ. An evaluation of the interaction between tiagabine and oral contraceptives in female volunteers. J Pharm Med. 1994; 4(3):141-150. (Pubitemid 24301554)
15. Griffith SG, Dia Y. Effect of zonisamide on the pharmacokinetics and pharmacodynamics of a combination ethinyl estradionor-ethindrone oral contraceptive in healthy women. Clin Ther. 2004;26(12):2056-2065. (Pubitemid 40353615)
16. ACOG practice bulletin. No. 73: use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2006; 107(6):1453-1472.
17. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Epilepsia. 1998;39(11):1226-1231.
18. World Health Organization. Medical eligibility criteria for contraceptive use, 2004. 3rd ed. http://www.who.int/reproductive-health/publications/mec/mec. pdf. Accessed July 7, 2008.