Randomized, Placebo-Controlled, Crossover Trial of Memantine for Cognitive Changes with Corticosteroid Therapy

Biological Psychiatry

Volumn 64, Issue 8, 2008, Pages 727-729

  Brown, E Sherwood ^a   Vazquez, Miguel ^b   Nakamura, Alyson ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Corticosteroid; depression; hippocampus; mania; memantine; memory

Indexed keywords

CREATININE; MEMANTINE; PLACEBO; PREDNISONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CREATININE BLOOD LEVEL; CROSSOVER PROCEDURE; DECLARATIVE MEMORY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; FEMALE; HAMILTON SCALE; HUMAN; LEARNING TEST; LONG TERM CARE; MALE; MANIA; MOOD; OUTPATIENT; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; ADULT; AGED; COGNITION DISORDERS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMANTINE; MIDDLE AGED; NOOTROPIC AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME; VERBAL LEARNING; YOUNG ADULT;

EID: 52949153576     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.05.010     Document Type: Article

References (19)

1. Brown E.S., Rush A.J., and McEwen B.S. Hippocampal remodeling and damage by corticosteroids: Implications for mood disorders. Neuropsychopharmacology 21 (1999) 474-484
2. Sapolsky R.M. The possibility of neurotoxicity in the hippocampus in major depression: A primer on neuron death. Biol Psychiatry 48 (2000) 755-765
3. Starkman M.N., Gebarski S.S., Berent S., and Schteingart D.E. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry 32 (1992) 756-765
4. Starkman M.N., Giordani B., Berent S., Schork M.A., and Schteingart D.E. Elevated cortisol levels in Cushing's disease are associated with cognitive decrements. Psychosom Med 63 (2001) 985-993
5. Brown E.S., Woolston J., Frol A., Bobadilla L., Khan D.A., Hanczyc M., et al. Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. Biol Psychiatry 55 (2004) 538-545
6. Moghaddam B., Bolinao M.L., Stein-Behrens B., and Sapolsky R. Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res 655 (1994) 251-254
7. Stein-Behrens B.A., Lin W.J., and Sapolsky R.M. Physiological elevations of glucocorticoids potentiate glutamate accumulation in the hippocampus. J Neurochem 63 (1994) 596-602
8. Magarinos A.M., Deslandes A., and McEwen B.S. Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. Eur J Pharmacol 371 (1999) 113-122
9. Magarinos A.M., and McEwen B.S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience 69 (1995) 89-98
10. Starkman M.N., Giordani B., Gebarski S.S., and Schteingart D.E. Improvement in learning associated with increase in hippocampal formation volume. Biol Psychiatry 53 (2003) 233-238
11. Brown E.S., Frol A., Bobadilla L., Nejtek V.A., Perantie D.C., and Dhillon H. Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids. Psychosomatics 44 (2003) 204-208
12. Brown E.S., Wolfshohl J., Shad M.U., Vazquez M., and Osuji I.J. Attenuation of the effects of corticosteroids on declarative memory with lamotrigine. Neuropsychopharmacology (2008) [published online ahead of print November 14]
13. Parsons C.G., Stoffler A., and Danysz W. Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse. Neuropharmacology 53 (2007) 699-723
14. Tariot P.N., Farlow M.R., Grossberg G.T., Graham S.M., McDonald S., Gergel I., and Memantine Study Group. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial. JAMA 291 (2004) 317-324
15. Brandt J. The Hopkins Verbal Learning Test: Development of a new memory test with six equivalent forms. Clin Neuropsychol 5 (1991) 125-142
16. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960) 56-62
17. Young R.C., Biggs J.T., Ziegler V.E., and Meyer D.A. A rating scale for mania: Reliability, validity and sensitivity. Br J Psychiatry 133 (1978) 429-435
18. Potter J.M., McWhinney B.C., Sampson L., and Hickman P.E. Area-under-the-curve monitoring of prednisolone for dose optimization in a stable renal transplant population. Ther Drug Monit 26 (2004) 408-414
19. Brown E.S., Suppes T., Khan D.A., and Carmody III T.J. Mood changes during prednisone bursts in outpatients with asthma. J Clin Psychopharmacol 22 (2002) 55-61