Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapes

PLoS Computational Biology

Volumn 4, Issue 9, 2008, Pages

  Clune, Jeff ^a,b   Misevic, Dusan ^c   Ofria, Charles ^a   Lenski, Richard E ^d   Elena, Santiago F ^b,e   Sanjuán, Rafael ^b,f  

^a Michigan State University   (United States)

^b Ciudad Politécnica de la Innovación   (Spain)

^c ETH ZURICH   (Switzerland)

^d Santa Fe Institute ^*  (United States)

^e SANTA FE INSTITUTE   (United States)

^f UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CONDITION; EXPERIMENTAL PARAMETERS; FITNESS LANDSCAPE; HIGH RATE; MUTATION RATES; NATURAL SELECTION; NEAR-OPTIMAL; OPTIMAL MUTATION; PARAMETER-SETTING; RATE OPTIMIZATIONS;

BIOLOGY;

ADAPTATION; ARTICLE; GENOTYPE; MOLECULAR EVOLUTION; MUTANT; MUTATION; NATURAL SELECTION; PROBABILITY; BIOLOGICAL MODEL; BIOLOGY; COMPUTER SIMULATION; EVOLUTION; GENETIC SELECTION; GENETICS; TIME;

ADAPTATION, PHYSIOLOGICAL; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; EVOLUTION; MODELS, GENETIC; MUTATION; SELECTION (GENETICS); TIME FACTORS;

EID: 52949144577     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000187     Document Type: Article

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