Quantification of lubricant activity of magnesium stearate by atomic force microscopy

Drug Development and Industrial Pharmacy

Volumn 34, Issue 10, 2008, Pages 1097-1099

  Weber, Daniel ^a   Pu, Yu ^a   Cooney, Charles L ^a  

^a Massachusetts Institute of Technology   (United States)

Author keywords

Atomic force microscopy; Cohesion force; Magnesium stearate; Microcrystalline cellulose

Indexed keywords

MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; STEEL;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL INTERACTION; DRUG FORMULATION; LUBRICATION; POWDER; QUANTITATIVE ANALYSIS; TABLET COMPRESSION;

CELLULOSE; LUBRICANTS; MICROSCOPY, ATOMIC FORCE; STEARIC ACIDS; TABLETS;

EID: 52949140822     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040801965061     Document Type: Article

References (10)

1. Barra, J., & Somma, R. (1996). Influence of the physicochemical variability of magnesium stearate on its lubricant properties: Possible solutions. Drug Dev. Ind. Pharm., 22(11), 1105-1120.
2. Begat, P., Morton, D. A. V., Staniforth, J. N., & Price, R. (2004). The cohesive-adhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy. Pharm. Res., 21(9), 1591-1597.
3. Berard, V., Lesniewska, E., Andres, C., Pertuy, D., Laroche, C., & Pourcelot, Y. (2002). Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy. Int. J. Pharm., 247(1-2), 127-137.
4. Ertel, K. D. & Carstensen, J. T. (1988). Chemical, physical, and lubricant properties of magnesium stearate. J. Pharm. Sci. - USA, 77(7), 625-629.
5. Eve, J. K., Patel, N., Luk, S. Y., Ebbens, S. J., & Roberts, C. J. (2002). A study of single drug particle adhesion interactions using atomic force microscopy. Int. J. Pharm., 238(1-2), 17-27.
6. Hooton, J. C., German, C. S., Allen, S., Davies, M. C., Roberts, C. J., Tendler, S. J. B., & Williams, P. M. (2003). Characterization of particle-interactions by atomic force microscopy: Effect of contact area. Pharm. Res., 20(3), 508-514.
7. Lee, J. (2004). Intrinsic adhesion force of lubricants to steel surface. J. Pharm. Sci. - USA, 93(9), 2310-2318.
8. Otsuka, M., Yamane, I., & Matsuda, Y. (2004). Effects of lubricant mixing on compression properties of various kinds of direct compression excipients and physical properties of the tablets. Adv. Powder Technol., 15(4), 477-493.
9. Sindel, U., & Zimmermann, I. (2001). Measurement of interaction forces between individual powder particles using an atomic force microscope. Powder Technol., 117(3), 247-254.
10. Wada, Y., & Matsubara, T. (1994). Pseudopolymorphism and lubricating properties of magnesium stearate. Powder Technol., 78(2), 109-114.