A study of single drug particle adhesion interactions using atomic force microscopy

International Journal of Pharmaceutics

Volumn 238, Issue 1-2, 2002, Pages 17-27

  Eve, J K ^a   Patel, N ^a   Luk, S Y ^a   Ebbens, S J ^a   Roberts, C J ^b  

^a Molecular Profiles Ltd   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Adhesion; Atomic force microscopy; Inhalation devices

Indexed keywords

FLUOROPOLYMER; GLASS; LACTOSE; POLITEF; POLYMER; SALBUTAMOL; UNCLASSIFIED DRUG;

ADHESION; ARTICLE; ATOMIC FORCE MICROSCOPY; METERED DOSE INHALER; METHODOLOGY; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

ADHESIVENESS; ALBUTEROL; EXCIPIENTS; GLASS; IMAGE PROCESSING, COMPUTER-ASSISTED; LACTOSE; MICROSCOPY, ATOMIC FORCE; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POLYTETRAFLUOROETHYLENE; POWDERS; SURFACE PROPERTIES;

EID: 0037093674     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00055-8     Document Type: Article

References (30)

1. The structure of α-lactose monohydrate
2. Fractal morphology of drug aggregates in aerosol propellant suspensions
3. Pharmaceutical dry powder aerosols: Correlation of powder properties with dose delivery and implications for pharmacodynamic effect
4. Direct measurement of colloidal Forces using an Atomic Force Microscope
5. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation
6. Contact Electrification Studies using atomic force microscope techniques
7. The generation of a respirable cloud from coarse powder aggregates
8. The ascent of pulmonary drug delivery
9. Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate
10. Calibration of atomic-force microscope tips
11. Quantifying surface topography and scanning probe image reconstruction
12. 4]
13. Characteristaion of adhesional properties of lactose carriers using atomic force microscopy
14. Aerosol-particle generation from dry powder inhalers - Can they equal pressurized metered-dose inhalers
15. Evaluation of the adhesion properties of salbutamol sulphate to inhaler materials
16. The relationship between physical properties of lactose monohydrate and the aerodynamic behaviour of adhered drug particles
17. Development of an ultracentrifuge technique to determine the adhesion and friction properties between particles and surfaces
18. The adhesion force of micronized Salmeterol Xinafoate particles to pharmaceutically relevant surface materials
19. Force-induced melting of a short DNA double helix
20. Treating systemic disease via the lung
21. Mechanisms and factors affecting intrapulmonary particle deposition:implications for efficient inhalation therapies,
22. Performance-modifying influences in dry powder inhalation systems
23. In vitro evaluation of dry powder inhalers II: Influence of carrier particle size and concentration on in vitro deposition
24. Probing protein-peptide-protein molecular architecture by atomic force microscopy and surface plasmon resonance
25. Measurement of interaction forces between silica and alpha-alumina by atomic force microscopy
26. New approach to the study of particle-surface adhesion using atomic force microscopy
27. Effect of particle shape on mixing of powders
28. Effect of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation