The disposition of diammonium glycyrrhizinate and glycyrrhetinic acid in the isolated perfused rat intestine and liver

Planta Medica

Volumn 74, Issue 11, 2008, Pages 1351-1356

  Yang, Jin ^a   Zhou, Liang ^a   Wang, Jiping ^b   Wang, Cuangji ^a   Davey, Andrew K ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Glycyrrhetinic acid; Glycyrrhizinate; Perfused intestine; Perfused liver; Pharmacokinetics; Rat

Indexed keywords

DIAMMONIUM GLYCYRRHIZINATE; GLYCYRRHETINIC ACID; GLYCYRRHIZA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG FORMULATION; GLYCYRRHIZA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INTESTINE FLORA; MALE; NONHUMAN; ORGAN PERFUSION; RAT;

ANIMALS; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; INTESTINAL ABSORPTION; INTESTINE, SMALL; LIVER; MALE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 52949138699     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081328     Document Type: Article

References (19)

1. Chen H. The progress of research on the pharmacology of licorice root. J Jilin AgricSci Technol College 2006; 15:15-8
2. Liu J, Bai Y, Tian C. Progress of application of composed glycyrrhizin in treating hepatic diseases. China Pharm 2006; 17:1823-30
3. Hattori M, Sakamoto T, Kobashi K, Namba T. Metabolism of glycyrrhizin by human intestinal flora. Planta Med 1983; 48: 38-42
4. Ploeger B, Mensinga J, Sips A, Seinen W, Meulenbelt J, DeJongh J. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. Drug Metab Rev 2001; 33: 125-47
5. Li D, Li D, Li Y. Development in the study of chemical components and pharmacological reaction in Glycyrrhiza uralensis Fisch. Inform Tradit Chin Med 1995; 5:31-5
6. Pompei R, Flore O, Marccialis MA, Pani A, Loddo B. Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature 1979; 281: 689-90
7. Sun X, Huang L, Liu X. Analysis of the chemical components in Glycyrrhiza uralensis Fisch. Acta Chin Med Pharmacol 1994; 5: 40-2
8. White PC. 11beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess. Am J Med Sci 2001; 322: 308-15
9. Qin G, Shi C, Song Y, Chen M. Meta-analysis of document on diammonium glycyrrhizinate in treatment of patients with chronic hepatitis B. Chin J Infect Dis 2005; 23: 333-7
10. Ishida S, Sakiya Y, Taira Z. Disposition of glycyrrhizin in the perfused liver of rats. Biol Pharm Bull 1994; 17: 960-9
11. Barthe L, Woodley J, Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin Pharmacol 1999; 13: 154-68
12. Song N-N, Li Q-S, Liu C-X. Intestinal permeability of metformin using single-pass intestinal perfusion in rats. World J Gastroenterol 2006; 12: 4064-70
13. Wang J, Nation RL, Evans AM, Cox S, Shackleford D. Metabolism and disposition of the antiviral nucleoside analogue AM365 in the isolated perfused rat liver. Curr Drug Metab 2005; 6: 487-93
14. Bais R, Philcox M. Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 8. IFCC method for lactate dehydrogenase. Eur J Clin Chem Clin Biochem 1994; 32: 639-55
15. Bergmeyer HU, Horder M. IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase. J Clin Chem Clin Biochem 1980: 18: 521-34
16. Moss DW. Provisional recommendations on IFCC methods for the measurement of catalytic concentrations of enzymes. Part 3. Revised IFCC method for aspartate aminotransferase. Eur J Clin Chem Clin Biochem 1977; 15:719-20
17. Krahenbuhl S, Hasler F, Krapf R. Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals. Steroids 1994; 59: 121-6
18. Okamura N, Miyauchi H, Choshi T, Ishizu T, Yagi A. Simultaneous determination of glycyrrhizin metabolites formed by the incubation of glycyrrhizin with rat feces by semi-micro high-performance liquid chromatography. Biol Pharm Bull 2003; 26: 658-61
19. Ishida S, Sakiya Y, Ichikawa T, Awazu S. Pharmacokinetics of glycyrrhetic acid, a major metabolite of glycyrrhizin. in rats. Chem Pharm Bull 1989: 37: 2509-13