Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 8801-8805

  Pôças, Elisa S C ^a,b   Touza, Natália A ^a   Pimenta, Paulo H C ^a   Leitão, Fernanda B ^a   Neto, Chaquip D ^a   da Silva, Alcides J M ^a   Costa, Paulo R R ^a   Noël, François ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO FEDERAL DE EDUCAÇÃO   (Brazil)

Author keywords

ATPase; Coumestan; Enzyme inhibition; Redox; Sulfydryl

Indexed keywords

2 METHOXY 3,8,9 TRIHYDROXYCOUMESTAN; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYSTEINE; DITHIOTHREITOL; ENZYME INHIBITOR; MERCAPTOETHANOL; OUABAIN; PCALC 36; REAGENT; SODIUM POTASSIUM ATPASE INHIBITOR; THIOL DERIVATIVE; UNCLASSIFIED DRUG; WEDELOLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MOLECULAR MECHANICS; NONHUMAN; OXIDATION REDUCTION REACTION; RAT;

ANIMALS; ANTICOAGULANTS; CA(2+) MG(2+)-ATPASE; CATALYTIC DOMAIN; COUMARINS; DITHIOTHREITOL; ENZYME INHIBITORS; H(+)-K(+)-EXCHANGING ATPASE; ISOFLAVONES; KIDNEY; OXIDATION-REDUCTION; RATS; RATS, WISTAR; SODIUM-POTASSIUM-EXCHANGING ATPASE; SULFHYDRYL COMPOUNDS;

EID: 52949135144     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.007     Document Type: Article

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