New potent cathepsin G phosphonate inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 8863-8867

  Sieńczyk, Marcin ^a   Lesner, Adam ^b   Wysocka, Magdalena ^b   Łegowska, Anna ^b   Pietrusewicz, Ewa ^a   Rolka, Krzysztof ^b   Oleksyszyn, Józef ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF GDA SK   (Poland)

Author keywords

Cathepsin G; Peptidomimetic; Phosphonate irreversible inhibitor

Indexed keywords

4 GUANIDINE (TERT BUTOXYCARBONYL) 2 PHENYLGLYCINE DERIVATIVE; ACETYLPHENYLVALYLTHREONYLPHENYLGYCINE DERIVATIVE; ALPHA AMINOALKYLPHOSPHONATE DIPHENYL ESTER DERIVATIVE; CATHEPSIN G; CATHEPSIN G PHOSPHONATE INHIBITOR; CHYMOTRYPSIN; ENZYME INHIBITOR; N BENZYLOXYCARBONYLAMINO (4 GUANIDINO)PHOSPHONIC PHENYLGLYCINE; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; ENZYME INHIBITION; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LEUKOCYTE; MASS SPECTROMETRY; MOLECULAR WEIGHT; PEPTIDE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CATHEPSINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PHOSPHONIC ACIDS; PROTEASE INHIBITORS; RADIOLIGAND ASSAY; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 52949133709     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.069     Document Type: Article

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