Bioavailability of clarithromycin cyclodextrin ternary complexes upon oral administration to healthy beagle dogs

Drug Development and Industrial Pharmacy

Volumn 34, Issue 10, 2008, Pages 1048-1053

  Zhang, Xiangrong ^a   Zou, Meijuan ^a   Li, Sanming ^a   Chen, Xiaoyan ^b   Zhong, Dafang ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Bioavailability; Clarithromycin; Ternary inclusion complexes

Indexed keywords

14 HYDROXYCLARITHROMYCIN; BETA CYCLODEXTRIN; CITRIC ACID; CLARITHROMYCIN; DRUG METABOLITE; GELATIN; PHOSPHATE; ROXITHROMYCIN;

ALKALINITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CAPSULE FILLING; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SOLUBILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRIC ACID; CLARITHROMYCIN; DOGS; FEMALE; HYDROGEN-ION CONCENTRATION; MALE; MASS SPECTROMETRY; SOLUBILITY;

EID: 52949114566     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040801937474     Document Type: Article

References (14)

1. Barillaro, V., Bertholet, P., Henry de Hassonville, S., Ziemon, E., Evrard, B., Delattre, L., & Piel, G. (2004). Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide. J. Pharm. Pharm. Sci., 30, 378-388.
2. Barillaro, V., Dive, G., Bertholet, P., Evrard, B., Delattre, L., Eric, Z., & Piel, G. (2007). Theoretical and experimental investigations on miconazole/cyclodextrin/ acid complexes: molecular modeling studies. Int. J. Pharm., 342, 152-160.
3. Ferrero, J. L., Bopp, B. A., Marsh, K. C., Quigley, S. C., Johnson, M. J., Anderson, D. J., Lamm, J. E., Tolman, K. G., Sanders S. W., & Cavanaugh, J. H. (1990). Metabolism and disposition of clarithromycin in man. Drug Metab. Dispos., 18, 441-446.
4. Langtry, H. D., & Brogden, R. N. (1997). Clarithromycin. A review of its efficacy in the treatment of respiratory tract infections in immunocompetent patients. Drugs, 53, 973-1004.
5. Lerner, F. E., Caliendo, G., Santagade, V., Santana, G. S. M., Moraes, M. E. A., & De Nucci, G. (2000). Clarithromycin bioequivalence study of two oral formulation in healthy human volunteers. Int. J. Clin. Pharmacol. Ther., 38, 345-354.
6. Maitre, M. M., Longhi, M. R., & Granero, G. G. (2007). Ternary complexes of flurbiprofen with HP-beta-CD and ethanolamines characterization and transdermal delivery. Drug Dev. Ind. Pharm., 33, 311-326.
7. Nakagawa, Y., Itai, S., Yoshida, T., & Nafai, T. (1992). Physicochemical properties and stability in the acidic solution of a new macrolide antibiotic, clarithromycin, in comparison with erythromycin. Chem. Pharm. Bull., 40, 725-728.
8. Piette, M., Evrarda, B., Frankenneb, F., Chiapc, P., Bertholeta, P., Castagnea, D., Foidartb, J. M., Delattrea, L., & Piel, G. (2006). Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions. Eur. J. Pharm. Sci., 28, 189-195
9. Redenti, E., Szente, L., & Szejtli, J. (2001). Cyclodextrin complexes of salts of acidic drugs. Thermodynamic properties, structural features, and pharmaceutical applications. J. Pharm. Sci., 90, 979-986.
10. Redenti, E., Szente, L., & Szejtli, J. (2000). Drug/cyclodextrin/ hydroxy acid multicomponent systems. Properties and pharmaceutical applications. J. Pharm. Sci., 89(1), 1-8.
11. Salem, I. I., & Duzgunes, N., (2003). Efficacies of cyclodextrin-complexed and liposome-encapsulated clarithromycin against Mycobacterium avium complex infection in human macrophages. Int. J. Pharm., 250, 403-414.
12. Shah, V. P, Midha, K. K., & Findlay, J. W. (2000). Bioanalytical method validation-a revisit with a decade of progress. Pharm. Res., 17, 1551-1557.
13. Zhang, X. R., Zhang, Y. F., Zhong, D. F., Chen, Y., & Li, S. M. (2007). Investigation and physicochemical characterization of clarithromycin-citric acid-cyclodextrins ternary complexes. Drug Dev. Ind. Pharm., 33, 1-9.
14. Zhou, R., Moench, P., Heran, C., & Heran, C. (2005). pH-Dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a cannie model. Pharm. Res., 22, 188-192.