Inhibition of LFA-1 mediated T-cell motility by naphthoquinones

Planta Medica

Volumn 74, Issue 11, 2008, Pages 1383-1387

  Sheridan, Helen ^a   Hook, Ingrid ^a   Nestor, Cora ^a   Coppins, Jennifer ^a   Ehrhardt, Carsten ^a   Frankish, Neil ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

7 hydroxydunnione; Dunnione; HuT 78 T lymphocytes; Naphthoquinone; Plumbagin; T cell polarization

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 7 HYDROXYDUNNIONE; ANTHRAQUINONE; DIHYDROFURANONAPHTHOQUINONE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NAPHTHOQUINONE; PLUMBAGIN; RAMENTACEONE; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE MIGRATION INHIBITION TEST; POLARIZATION; T LYMPHOCYTE SUBPOPULATION;

CELL LINE; CELL MOVEMENT; HUMANS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; NAPHTHOQUINONES; T-LYMPHOCYTES;

EID: 52949099535     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081303     Document Type: Article

References (10)

1. Volkov Y. LongA, Kelleher D. Inside the crawlingTcell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes beta(l) and delta. J Immunol 1998; 161: 6487-95
2. Volkov Y, LongA, McCrath S, Ni Eidhin D, Kelleher D. Crucial importance of PKC-beta(l) in LFA-1 -mediated locomotion of activated T cells. Nat Immunol 2001; 2: 508-14
3. Weitz-Schmidt G, Weizenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001; 7: 687-92
4. Hsu YL, Cho CY, Kuo PL Huang YT, Lin CC. Plumbagin (5-hydroxy-2-methyl-l,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kin ase-mediated phosphorylation at serine 15 in vitro and in vivo. J Pharmacol Exp Ther 2006; 318: 484-94
5. Fanning A, Volkov Y, Freeley M, Kelleher D, Long A. CD44 cross-linking induces protein kinase C-regulated migration of human T lymphocytes. Int Immunol 2005; 17: 449-58
6. O'Brien PJ. Molecular mechanisms of quinone cytotoxicity. Chem Biol Interact 1991; 80: 1-41
7. Hook I. Naphthoquinone contents of in vitro cultured plants and cell suspensions of Dionaea muscipula and Drosera species. Plant Cell Tiss Org 2001; 67: 281-5
8. Wube AA, Streit B, Gibbons S, Asres K, BucarF. In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi. J Ethnopharmacol 2005; 102: 191-6
9. Nestor C. The production of quinones by in vitro cultures of Dionaea and Streptocarpus species. Dublin: Trinity College Dublin; 2006
10. Martiny-Baron MG, Kazanietz H, Miscbak PM, Blumberg C, Kochs H, Hug D et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 1993; 268: 9194-7