Detection of point mutations on 23S rRNA of Helicobacter pylori and resistance to clarithromycin with PCR-RFLP in gastric biopsy specimens in Mersin, Turkey

Turkish Journal of Gastroenterology

Volumn 19, Issue 3, 2008, Pages 163-167

  Sezgin, Orhan ^a,b   Aslan, Gönül ^a   Altintaş, Engin ^a   Tezcan, Seda ^a   Serin, Mehmet Sami ^a   Emekdaş, Gürol ^a  

^a MERSIN UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b MERSIN UNIVERSITY   (Turkey)

Author keywords

Clarithromycin; Helicobacter pylori; Resistance

Indexed keywords

CLARITHROMYCIN; RNA 23S;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; MALE; POINT MUTATION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STOMACH BIOPSY; TURKEY (REPUBLIC);

ANTI-BACTERIAL AGENTS; BIOPSY; CLARITHROMYCIN; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY, COMBINATION; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RNA, BACTERIAL; RNA, RIBOSOMAL; TURKEY;

EID: 52949097569     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Altintafl E, Sezgin O, Ulu O, et al. Maastricht II treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori. World J Gastroenterol 2004; 10: 1656-8.
2. Kadayifçi A, Büyükhatipoǧlu H, Savaş C, et al Eradication of Helicobacter pylori with triple therapy: an epidemiologic analysis of trends in Turkey over 10 years. Clin Ther 2006; 28: 1960-6.
3. Megraud F. Helicobacter pylori antibiotic resistance: prevalence, importance and advances in testing. Gut 2004; 53: 1374-84.
4. Dore MP, Leandro G, Realdi G, et al. Effect of pre-treatment antibiotic resistance to metronidazole and clarithromycin on outcome of H. pylori therapy: a meta-analytical approach. Dig Dis Sci 2000; 45: 68-76.
5. Glupczynski Y, Megraud F, Lopez-Brea M, et al. European multicenter survey of in vitro antimicrobial resistance in Helicobacter pylori. Eur J Clin Microbial Infect Dis 2000; 11: 820-3.
6. Boyarova L, Mentis A, Gubina M, et al. The status of antimicrobial resistance of H. pylori in Eastern Europe. Clin Microbial Infect 2002; 8: 388-96.
7. Fallone CA. Epidemiology of the antibiotic resistance of H. pylori in Canada. Can J Gastroenterol 2000; 14: 879-82.
8. Samra Z, Shmuely H, Niv Y, et al. Resistance of H. pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime. J Antimicrob Chemother 2002; 49: 1023-6.
9. Mohammadi M, Doroud D, Massarrat S, et al. Clarithromycin resistance in Iranian H. pylori strains before introduction of clarithromycin. Helicobacter 2003; 8: 79-80.
10. Perez Aldana L, Kato M, Nakogawa S, et al. The relationship between consumption of antimicrobial agents and the prevalence of primary H. pylori resistance. Helicobacter 2002; 7: 306-9.
11. Ling TKW, Leung WK, Lee CC, et al. The antimicrobial susceptibility of H. pylori in Hong Kong (1997-2001). Helicobacter 2002; 7: 327-9.
12. Kim JJ, Reddy R, Lee M, et al. Analysis of metronidazole, clarithromycin, and tetracycline resistance of H. pylori isolates from Korea. J Antimicrob Chemother 2001; 47: 459-61.
13. Mahachi V, Thang-Ngam D, Noopun P, et al. Efficacy of clarithromycin-based triple therapy for treating H. pylori in Thai dyspeptic patients with clarithromycin resistant strains. Helicobacter 2004; 9: A13-15.
14. Tumwasorn S, Leetranont S, Sawatpanich A, et al. Detection of clarithromycin resistance in H. pylori isolated from Thai patients. Helicobacter 2004; 9: A13.06.
15. Loivukene K, Maaroos HI, Kolk H, et al. Prevalence of antibiotic resistance of H. pylori isolates in Estonia during 1995-2000 in comparison to the consumption of antibiotics used in treatment regimen. Clin Microbial Infect 2002; 8: 598-603.
16. Birac C, Bouchard S, Camau C, et al. Six year follow-up of resistance to antibiotics of H. pylori in Bordeaux, France. Gut 1999; 45: A107.
17. Lee HS, Song HJ, Lee IS, et al. Clarithromycin and metronidazole resistance mechanisms of H. pylori isolated from Korean patients. Helicobacter 2004; 9: A13.07.
18. Ribeiro ML, Vitiello L, Miranda MCB, et al. Mutations in the 23S rRNA gene are associated with clarithromycin resistance in H. pylori isolates in Brazil. Ann Clin Microb Antimicrob 2003; 2: 11-8.
19. Çolakoǧlu S, Yeǧin M, Bayar B, et al. H. pilori tedavisinde klaritromisine karşi gelişen antibiyotik direncinin moleküler düzeyde incelenmesi. HeBiPa Kongresi 2004; SB06.
20. Çirak MY, Ünal S, Türet S, et al. H. piloride klaritromisin direncinin genetik olarak belirlenmesi. Turk J Gastroenterol 2003; 14: SB00/5.
21. Çirak MY, Ünal S, Ergin D, et al. Determination of 23S rDNA point mutations conferring clarithromycin resistance in H. pylori in Turkish patients. Helicobacter 2004; 9: A13.09.
22. Şahin F, Özden A, Ünver E, et al. Agar dilüsyon yöntemi ile H. pilori için metronidazol dirençlilik testi ve disk diffüzyon yöntemi ile amoksisillin ve klaritromisin'in H. piloriye etkisi. Turk J Gastroenterol 1994; 5: 203-6.
23. Aydin A, Büke Ç, Akiner C, et al. H. pilorinin klaritromisine duyarliliǧi azaliyor mu? Turk J Gastroenterol 1998; 9: PB.164.
24. Palabiyikoǧlu M, Şahin F, Özden A, et al. Disk diffüzyon yöntemi ile H. pilori klinik izolatlarinda amoksisilline ve klaritromisine karşi primer duyarliliǧin araştirilmasi ve tedavi sonrasi muhtemel duyarlilik deǧiş ikliǧinin incelenmesi. Turk J Gastroenterol 1997; 8: 309-12.
25. Göral V, Yildiz FZ, Gül K, et al. H. pilori infeksiyonunda antibiyotik direnci. Turk J Gastroenterol 1999; 10: SB15.
26. Kantarçeken B, Yildirim B, Karincaoǧlu M, et al. H. pylori and antibiotic resistance. Turk J Gastroenterol 2000; 11: 141-5.
27. Ergin D, Erciş S, Özaslan E, et al. E-test yöntemi ile H. pilorinin çeşitli antibiyotiklere karşi duyarliliǧinin belirlenmesi. Turk J Gastroenterol 2001; 12: SB/15.
28. Işiksal F, Çolakoǧlu S, Köksal F, et al. H. pilori antibiyotik direnci. Turk J Gastroenterol 2003; 14: SB.07/5.
29. Çirak MY, Ünal S, Türet S, et al. H. piloride klaritromisin direncinin PCR-Beacon tekniǧi ile genetik olarak belirlenmesi. HeBiPa Kongresi 2004; P18.
30. Çirak MY, Ünal S, Türet S, et al. H. pilori infeksiyonunda klaritromisin direncinin RT-PCR tekniǧi ile genetik olarak belirlenmesi. Turk J Gastroenterol 2004; 15: PB.08/30.
31. Hülagu S, Uraz S, Kolayli F, et al. H. pilorinin farkli hasta gruplarinda klaritromisin, amoksisillin ve metronidazol rezistansi. HeBiPa Kongresi 2004; SB.07.
32. Önder GF, Aydin A, Akarca US, et al. High Helicobacter pylori resistance rate to clarithromycin in Turkey. J Clin Gastroenterol 2007; 41: 747-50.
33. Özden A, Bozdayi G, Baǧlan P, et al. H. pilorinin klaritromisine karşi direncinin sikliǧi. Turk J Gastroenterol 2004; 15: SB.07/6
34. Aydin A, Önder GF, Akarca US, et al. The efficacy of twoweek therapy with ranitidine bismuth citrate, amoxicillin and clarithromycin on H. pylori eradication in clarithromycin resistant and sensitive cases. Turk J Gastroenterol 2005; 16: 203-6.
35. Baǧlan PH, Bozdayi G, Özkan M, et al. Klaritromisin dirençli H. pilorinin saptanmasinda E-test ve Agar dilüsyon metodlerinin karşilaştirilmasi. Akademik Gastroenteroloji Dergisi 2005; 4: 83-7.
36. Baǧlan P, Bektaş M, Çinar K, et al. H. pilori suşlarinin klaritromisine direnç prevalansinin "FİSH" yöntemi ile belirlenmesi. Turk J Gastroenterol 2006; 17: PB.02/23.
37. Akkaya D, Demir M, Göktürk HS, et al. Tip II DM'lu hastalarda H. pilori eradikasyonu ve klaritromisin rezistansi. Turk J Gastroenterol 2006; 17: PB.02/19.
38. Tüzün Y, Yilmaz Ş, Bayan K, et al. Klaritromisin primer ve sekonder H. pilori direnci prevalansi, katkida bulunan olasi faktörler: Güneydoǧu Anadolu'dan veriler. Turk J Gastroenterol 2006; 17: PB.02/1.
39. Houben MH, van de Beck, Henden EF, et al. A systematic review of Helicobacter pylori eradication therapy: the impact of antimicrobial resistance on eradication rates. Aliment Pharmacol Ther 1999; 13: 1047-55.