Reduction of topical anesthetic onset time using ultrasound: A randomized controlled trial prior to venipuncture in young children

Pain Medicine

Volumn 9, Issue 7, 2008, Pages 795-802

  Zempsky, William T ^a,b,c   Robbins, Bertha ^b   Mckay, Kathleen ^b,c  

^a Pain Relief Program   (United States)

^b Farmington   (United States)

^c UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

Pain; Topical Anesthesia; Ultrasound

Indexed keywords

LIDOCAINE;

ANALGESIC ACTIVITY; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FACES PAIN SCALE; FEMALE; HUMAN; MALE; PAIN ASSESSMENT; PEDIATRIC ANESTHESIA; PHLEBOTOMY; RANDOMIZED CONTROLLED TRIAL; SKIN ABRASION; SKIN REDNESS; TREATMENT DURATION; ULTRASOUND THERAPY; VEIN PUNCTURE; VISUAL ANALOG SCALE;

ADMINISTRATION, TOPICAL; ANESTHETICS, LOCAL; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; LIDOCAINE; MALE; PAIN; PAIN MEASUREMENT; PHLEBOTOMY; SONICATION; TIME FACTORS; TREATMENT OUTCOME; ULTRASONIC THERAPY;

EID: 52949090792     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2008.00421.x     Document Type: Article

References (18)

1. Package Insert L.M.X.4. Ferndale, MI: Ferndale Laboratories, Inc.
2. Package Insert EMLA. Wilmington, DE: Astra-Zeneca Corp.
3. Zempsky WT, Anand KJS, Sullivan KM, et al. Lidocaine iontophoresis for topical anesthesia before intravenous line placement in children. J Pediatr 1998;132:1061-3.
4. Kim MK, Kini NM, Trshynski TJ, Hennes HM. A randomized clinical trial of dermal anesthesia by iontophoresis for peripheral intravenous catheter placement in children. Ann Emerg Med 1999;33:359-9.
5. Katz NP, Shapiro DE, Herrmann TE, Kost J, Custer LM. Rapid onset of cutaneous anesthesia with EMLA cream after pretreatment with a new ultrasound-emitting device. Anesth Analg 2004;98:371-6.
6. Becker BM, Helfrich S, Baker E, et al. Ultrasound with topical anesthetic rapidly decreases pain of intravenous cannulation. Acad Emerg Med 2005;12:289-95.
7. Skarbek-Borowska S, Becker BM, Lovgren K, Bates A, Minugh PA. Brief focal ultrasound and topical anesthetic decreases the pain of IV placement in children. Proceedings of the Pediatric Academic Societies, May, 2005, Washington, DC.
8. Mitragotri S, Kost J. Low-frequency sonophoresis: A non-invasive method of drug delivery and diagnosis. Biotechnol Prog 2000;16:488-92.
9. Tezel A, Sens A, Tuchscherer J, Mitragotri S. Synergistic effect of low-frequency ultrasound and surfactants on skin permeability. J Pharm Sci 2002;91:91-100.
10. Mitragotri S, Ray D, Farrell J, et al. Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport. J Pharm Sci 2000;89:892-900.
11. Kost J, Mitragotri S, Gabbay RA, Pishko M, Langer R. Transdermal monitoring of glucose and other analytes using ultrasound. Nature Med 2000;6:347-50.
12. Kost J. Ultrasound assisted insulin delivery and non-invasive glucose sensing. Diabetes Technol Ther 2002;4:489-97.
13. Luhmann J, Hurt S, Shootman M, Kennedy R. A comparison of buffered lidocaine versus ELA-Max before peripheral intravenous catheter insertions in children. Pediatrics 2004;113:e217-20.
14. Taddio A, Soin HK, Schuh S, Koren G, Scolnik D. Liposomal lidocaine to improve procedure success rates and reduce procedural pain among children: A randomized controlled trial. CMAJ 2005;172:1691-5.
15. Beyer J, Villarruel AM, Denyes M. The Oucher: The New Users Manual and Technical Report. Denver, CO: Health Sciences Center, University of Colorado; 1993.
16. Eichenfeld LF, Funk A, Fallon-Friedlander S, Cunnigham BB. A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with Eutectic Mixture of Local Anesthetics for Pain Reduction of Venipuncture in Children. Pediatrics 2002;109:1093-9.
17. Kleiber C, Sorenson M, Whiteside K, Gronstal BA, Tannous R. Topical anesthetics for intravenous insertion in children: A randomized equivalency study. Pediatrics 2002;110:758-61.
18. Champion GC, Goodenough B, Von Baeyer CL, Thomas W. Measurement of pain by self report. In: Finley GA, McGrath PJ, eds. Measurement of Pain in Infant and Children. Seattle, WA: IASP Press; 1998: 123-60.