Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 10, 2008, Pages 1321-1334

  Veng Pedersen, Peter ^a   Freise, Kevin J ^a   Schmidt, Robert L ^b   Widness, John A ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTINUOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR; RECOMBINANT ERYTHROPOIETIN;

ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RECEPTOR BINDING; IN VITRO STUDY; MICHAELIS MENTEN KINETICS; NONHUMAN; RADIOIMMUNOASSAY; SHEEP;

EID: 52949089252     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.10.0008     Document Type: Article

References (22)

1. Bischoff, K. B. (1980) Current applications of physiological pharmacokinetics. Fed. Proc. 39: 2456-2459
2. Bischoff, K. B. (1986) Physiological pharmacokinetics. Bull. Math. Biol. 48: 309-322
3. Brandt, L. M., Lanzendorfer, M., Frische, J., Haselbeck, A., Jarsch, M. (2006) Different receptor binding activity of C.E.R.A. (continuous erythropoietin receptor activator) compared with epoetin beta determined by surface plasmon resonance and competition assay on UT-7 cells. Nephrol. Dial. Transplant. 21(Suppl. 4): iv8-iv9 Abstract SO018
4. Cutler, D. J. (1978) Linear systems analysis in pharmacokinetics. J. Pharmacokinet. Biopharm. 6: 265-282
5. Cutler, D. J. (1979) A linear recirculation model for drug disposition. J. Pharmacokinet. Biopharm. 7: 101-116
6. Fonseca-Costa, A., Zin, W. A. (1979) Cardiac output and mean transit time using the phase plane of dye-dilution curves. Am. J. Physiol. 236: H798-H801
7. Jarch, M., Brandt, M., Lanzendörfer, M., Haselbeck, A. (2008) Comparative erythropoietin receptor binding kinetics of C.E.R.A. and epoetin-β determined by surface plasmon resonance and competition binding assay. Pharmacology 81: 63-69
8. Marzo, A., Rescigno, A. (1993) Pharmacokinetics of endogenous substances: some problems and some solutions. Eur. J. Drug Metab. Pharmacokin et. 18: 77-88
9. Picker, O., Wietasch, G., Scheeren, T. W., Arndt, J. O. (2001) Determination of total blood volume by indicator dilution: a comparison of mean transit time and mass conservation principle. Intensive Care Med. 27: 767-774
10. Veng-Pedersen, P. (1977) Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. J. Pharmacokinet. Biopharm. 5: 513-531
11. Veng-Pedersen, P. (1988a) Linear and nonlinear system approaches in pharmacokinetics: how much do they have to offer? I. General considerations. J. Pharmacokinet. Biopharm. 16: 413-472
12. Veng-Pedersen, P. (1988b) Linear and nonlinear system approaches in pharmacokinetics: how much do they have to offer? II. The response mapping operator (RMO) approach. J. Pharmacokinet. Biopharm. 16: 543-571
13. Veng-Pedersen, P. (1988c) System approaches in pharmacokinetics: I. Basic concepts. J. Clin. Pharmacol. 28: 1-5
14. Veng-Pedersen, P. (1988d) System approaches in pharmacokinetics: II. Applications. J. Clin. Pharmacol. 28: 97-104
15. Veng-Pedersen, P. (1989a) Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part I). Clin. Pharmacokinet. 17: 345-366
16. Veng-Pedersen, P. (1989b) Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II). Clin. Pharmacokinet. 17: 424-440
17. Veng-Pedersen, P. (1991) Stochastic interpretation of linear pharmacokinetics: a linear system analysis approach. J. Pharm. Sci. 80: 621-631
18. Veng-Pedersen, P. (2001) Noncompartmentally-based pharmacokinetic modeling. Adv. Drug Deliv. Rev. 48: 265-300
19. Verotta, D., Sheiner, L. B., Ebling, W. F., Stanski, D. R. (1989) A semiparametric approach to physiological flow models. J. Pharmacokinet. Biopharm. 17: 463-491
20. von Spiegeland, T., Hoeft, A. (1998) Transpulmonary indicator methods in intensive medicine. Anaesthesist 47: 220-228
21. Weiss, M., Krejcie, T. C., Avram, M. J. (2007) A minimal physiological model of thiopental distribution kinetics based on a multiple indicator approach. Drug Metab. Dispos. 35: 1525-1532
22. Widness, J. A., Schmidt, R. L., Veng-Pedersen, P., Modi, N. B., Sawyer, S. T. (1992) A sensitive and specific erythropoietin immunoprecipitation assay: application to pharmacokinetic studies. J. Lab. Clin. Med. 119: 285-294