Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

Biochemical Pharmacology

Volumn 76, Issue 8, 2008, Pages 997-1005

  Naesens, Lieve ^a   Andrei, Graciela ^a   Votruba, Ivan ^b   Krečmerová, Marcela ^b   Holý, Antonín ^b   Neyts, Johan ^a   De Clercq, Erik ^a   Snoeck, Robert ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acyclic nucleoside phosphonate; Cidofovir; HPMP 5 azaC; HPMPC

Indexed keywords

1 [3 HYDROXY 2 (PHOSPHONOMETHOXY)PROPYL] 5 AZACYTOSINE; ANTIVIRUS AGENT; CIDOFOVIR; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DRUG METABOLITE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DEAMINATION; DNA VIRUS; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SELECTIVITY; DRUG STABILITY; FEMALE; HERPES VIRUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHOSPHORYLATION; POXVIRUS; PRIORITY JOURNAL; RADIOACTIVITY; VIRUS INFECTION; WILD TYPE;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CYTOSINE; DNA REPLICATION; DNA VIRUSES; DNA, NEOPLASM; DRUG STABILITY; FEMALE; HERPESVIRUS 1, HUMAN; HUMANS; LUNG NEOPLASMS; LYMPHOMA, NON-HODGKIN; MICE; MICE, INBRED STRAINS; PHOSPHONIC ACIDS;

EID: 52949088625     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.08.009     Document Type: Article

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