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Volumn 2, Issue 1, 2000, Pages

Molecular modeling of g-protein coupled receptor kinase 2: Docking and biochemical evaluation of inhibitors

Author keywords

Homology modeling; Suramin; Suramin analogues; Trifluoperazine

Indexed keywords


EID: 52849134828     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (41)
  • 1
    • 0027194487 scopus 로고
    • G protein-coupled receptor kinases
    • Lefkowitz RJ. G protein-coupled receptor kinases. Cell. 1993;74:409-412.
    • (1993) Cell. , vol.74 , pp. 409-412
    • Lefkowitz, R.J.1
  • 2
    • 0025223081 scopus 로고
    • Turning off the signal: Desensitization of beta-adrenergic receptor function published erratum appears
    • Sep; 3049J.FASEB J. 1990;4
    • Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: Desensitization of beta-adrenergic receptor function [published erratum appears in FASEB J 1990 Sep; 4(12):3049J.FASEB J. 1990;4:2881-2889.
    • (1990) FASEB J , vol.4 , Issue.12 , pp. 2881-2889
    • Hausdorff, W.P.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 4
    • 0027981478 scopus 로고
    • G protein-coupled receptor kinases
    • Haga T, Haga K, Kameyama K. G protein-coupled receptor kinases. J Neurochem. 1994;63:400-412.
    • (1994) J Neurochem. , vol.63 , pp. 400-412
    • Haga, T.1    Haga, K.2    Kameyama, K.3
  • 6
    • 0024412926 scopus 로고
    • Beta-adrenergic receptor kinase: Primary structure delineates a multigene family
    • Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: Primary structure delineates a multigene family. Science. 1989;246:235-240.
    • (1989) Science , vol.246 , pp. 235-240
    • Benovic, J.L.1    Deblasi, A.2    Stone, W.C.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 7
    • 0023610955 scopus 로고
    • Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase
    • Benovic JL, Regan JW, Matsui H, et al. Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. J Biol Chem. 1987;262:17251-17253.
    • (1987) J Biol Chem. , vol.262 , pp. 17251-17253
    • Benovic, J.L.1    Regan, J.W.2    Matsui, H.3
  • 8
    • 0024372284 scopus 로고
    • Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase
    • Kwatra MM, Benovic JL, Caron MG, Lefkowitz RJ, Hosey MM. Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase. Biochemistry. 1989;28:4543-4547.
    • (1989) Biochemistry. , vol.28 , pp. 4543-4547
    • Kwatra, M.M.1    Benovic, J.L.2    Caron, M.G.3    Lefkowitz, R.J.4    Hosey, M.M.5
  • 9
    • 0030066616 scopus 로고    scopus 로고
    • Phosphorylation of human ml muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C
    • Haga K, Kameyama K, Haga T, Kikkawa U, Shiozaki K, Uchiyama H. Phosphorylation of human ml muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C. J Biol Chem. 1996;271:2776-2782.
    • (1996) J Biol Chem. , vol.271 , pp. 2776-2782
    • Haga, K.1    Kameyama, K.2    Haga, T.3    Kikkawa, U.4    Shiozaki, K.5    Uchiyama, H.6
  • 10
    • 0029085874 scopus 로고
    • Agonist-dependent Phosphorylation of the mouse delta-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase
    • Pei G, Kieffer BL, Lefkowitz RJ, Freedman NJ. Agonist-dependent Phosphorylation of the mouse delta-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase C. Mol Pharmacol. 1995;48:173-177.
    • (1995) C. Mol Pharmacol. , vol.48 , pp. 173-177
    • Pei, G.1    Kieffer, B.L.2    Lefkowitz, R.J.3    Freedman, N.J.4
  • 11
    • 0022641020 scopus 로고
    • Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase
    • Benovic JL, Mayor FJ, Somers RL, Caron MG, Lefkowitz RJ. Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. Nature. 1986;321:869-872.
    • (1986) Nature. , vol.321 , pp. 869-872
    • Benovic, J.L.1    Mayor, F.J.2    Somers, R.L.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 12
    • 0026322813 scopus 로고
    • Purification and characterization of beta-adrenergic receptor kinase
    • Benovic JL. Purification and characterization of beta-adrenergic receptor kinase. Methods Enzymol. 1991;200:351-362.
    • (1991) Methods Enzymol. , vol.200 , pp. 351-362
    • Benovic, J.L.1
  • 13
    • 0026342401 scopus 로고
    • Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase see commentsJ
    • Knighton DR, Zheng JH, Ten Eyck LF, et al. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase [see commentsJ. Science. 1991;253:407-414.
    • (1991) Science. , vol.253 , pp. 407-414
    • Knighton, D.R.1    Zheng, J.H.2    Ten Eyck, L.F.3
  • 14
    • 0027408171 scopus 로고
    • Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor
    • Zheng J, Knighton DR, Ten Eyck LF, Karlsson R, Xuong N, Taylor SS, Sowadski JM. Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry. 1993;32:2154-2161.
    • (1993) Biochemistry. , vol.32 , pp. 2154-2161
    • Zheng, J.1    Knighton, D.R.2    Ten Eyck, L.F.3    Karlsson, R.4    Xuong, N.5    Taylor, S.S.6    Sowadski, J.M.7
  • 15
    • 0030447681 scopus 로고    scopus 로고
    • Substrate recognition mechanism of human beta-adrenergic receptor kinase 1 based on a 2-dimensional model structure
    • Iino M, Shibano T. Substrate recognition mechanism of human beta-adrenergic receptor kinase 1 based on a 2-dimensional model structure. Drug Des Discov. 1996;14:145-155.
    • (1996) Drug des Discov. , vol.14 , pp. 145-155
    • Iino, M.1    Shibano, T.2
  • 18
    • 84986432941 scopus 로고
    • Automated docking with grid-based energy evaluation
    • Meng EC, Shoichet BK, Kuntz ID. Automated docking with grid-based energy evaluation. J Comp Chem. 1992;13:505-524.
    • (1992) J Comp Chem. , vol.13 , pp. 505-524
    • Meng, E.C.1    Shoichet, B.K.2    Kuntz, I.D.3
  • 19
    • 0030120054 scopus 로고    scopus 로고
    • Orientational sampling and rigid-body minimization in molecular docking revisited: On-the-fly optimization and degeneracy removal
    • Gschwend DA, Kuntz ID. Orientational sampling and rigid-body minimization in molecular docking revisited: On-the-fly optimization and degeneracy removal. J Comput Aided Mol Des. 1996;10:123-132.
    • (1996) J Comput Aided Mol Des. , vol.10 , pp. 123-132
    • Gschwend, D.A.1    Kuntz, I.D.2
  • 20
    • 0026730489 scopus 로고
    • Structure-based strategies for drug design and discovery see commentsJ
    • Kuntz ID. Structure-based strategies for drug design and discovery [see commentsJ. Science. 1992;257:1078-1082.
    • (1992) Science. , vol.257 , pp. 1078-1082
    • Kuntz, I.D.1
  • 21
    • 0026030641 scopus 로고
    • Database of homology-derived protein structures and the structural meaning of sequence alignment
    • Sander C, Schneider R. Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins. 1991;9:56-68.
    • (1991) Proteins. , vol.9 , pp. 56-68
    • Sander, C.1    Schneider, R.2
  • 22
    • 0027169638 scopus 로고
    • Improved prediction of protein secondary structure by use of sequence profiles and neural ne2rks
    • Rost B, Sander C. Improved prediction of protein secondary structure by use of sequence profiles and neural ne2rks. Proc Natl Acad Sci USA. 1993;90:7558-7562.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7558-7562
    • Rost, B.1    Sander, C.2
  • 23
    • 0027291015 scopus 로고
    • Prediction of protein secondary structure at better than 70% accuracy
    • Rost B, Sander C. Prediction of protein secondary structure at better than 70% accuracy. J Mol Biol. 1993;232:584-599.
    • (1993) J Mol Biol. , vol.232 , pp. 584-599
    • Rost, B.1    Sander, C.2
  • 24
    • 0017411710 scopus 로고
    • The Protein Data Bank: A computer-based archival file for macromolecular structures
    • Bernstein FC, Koetzle TF, Williams GJ, et al. The Protein Data Bank: A computer-based archival file for macromolecular structures. J Mol Biol. 1977;112:535-542.
    • (1977) J Mol Biol. , vol.112 , pp. 535-542
    • Bernstein, F.C.1    Koetzle, T.F.2    Williams, G.J.3
  • 26
    • 52849116258 scopus 로고    scopus 로고
    • Sybyl v6.04a. Tripos Associates Inc., St. Louis, MO.
    • Sybyl v6.04a. Tripos Associates Inc., St. Louis, MO.
  • 27
    • 0021107965 scopus 로고
    • Solvent-accessible surfaces of proteins and nucleic acids
    • Connolly ML. Solvent-accessible surfaces of proteins and nucleic acids. Science. 1983;221:709-713.
    • (1983) Science. , vol.221 , pp. 709-713
    • Connolly, M.L.1
  • 28
    • 0026326821 scopus 로고
    • Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase see comments
    • Knighton DR, Zheng JH, Ten Eyck LF, Xuong NH, Taylor SS, Sowadski JM. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase [see commentsJ. Science. 1991;253:414-420.
    • (1991) J. Science , vol.253 , pp. 414-420
    • Knighton, D.R.1    Zheng, J.H.2    Ten Eyck, L.F.3    Xuong, N.H.4    Taylor, S.S.5    Sowadski, J.M.6
  • 29
    • 52849115376 scopus 로고    scopus 로고
    • MDL Information Systems Inc., San Leandro, CA.
    • MDL Information Systems Inc., San Leandro, CA.
  • 30
    • 0027017305 scopus 로고
    • A fast and efficient method for 2D and 3D molecular shape description
    • Bemis GW, Kuntz ID. A fast and efficient method for 2D and 3D molecular shape description. J Comput Aided Mol Des. 1992;6:607-628.
    • (1992) J Comput Aided Mol Des , vol.6 , pp. 607-628
    • Bemis, G.W.1    Kuntz, I.D.2
  • 31
    • 0027418322 scopus 로고
    • Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase
    • Kameyama K, Haga K, Haga T, Kontani K, Katada T, Fukada Y. Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase. J Biol Chem. 1993;268:7753-7758.
    • (1993) J Biol Chem. , vol.268 , pp. 7753-7758
    • Kameyama, K.1    Haga, K.2    Haga, T.3    Kontani, K.4    Katada, T.5    Fukada, Y.6
  • 32
    • 0019956634 scopus 로고
    • Light-dependent phosphorylation of rhodopsin: Number of phosphorylation sites
    • Wilden U, Kühn H. Light-dependent phosphorylation of rhodopsin: Number of phosphorylation sites. Biochemistry. 1982;21:3014-3022.
    • (1982) Biochemistry. , vol.21 , pp. 3014-3022
    • Wilden, U.1    Kühn, H.2
  • 33
    • 0027439438 scopus 로고
    • The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP
    • Carrera AC, Alexandrov K, Roberts TM. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci USA. 1993;90:442-446.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 442-446
    • Carrera, A.C.1    Alexandrov, K.2    Roberts, T.M.3
  • 34
    • 0021751197 scopus 로고
    • Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase
    • Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984;23:5036-5041.
    • (1984) C. Biochemistry. , vol.23 , pp. 5036-5041
    • Hidaka, H.1    Inagaki, M.2    Kawamoto, S.3    Sasaki, Y.4
  • 37
    • 0000352275 scopus 로고
    • Eukaryotic protein kinases
    • Hanks SK. Eukaryotic protein kinases. Curr Opin Struct Biol. 1991;1:369-383.
    • (1991) Curr Opin Struct Biol. , vol.1 , pp. 369-383
    • Hanks, S.K.1
  • 39
    • 0024461389 scopus 로고
    • Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A
    • Hensey CE, Boscoboinik D, Azzi A. Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A. FEBS Lett. 1989;258:156-158.
    • (1989) FEBS Lett. , vol.258 , pp. 156-158
    • Hensey, C.E.1    Boscoboinik, D.2    Azzi, A.3
  • 40
    • 0025250131 scopus 로고
    • Effects of suramin, an antihuman immunodeficiency virus reverse transcriptase agent, on protein kinase C: Differential activation and inhibition of protein kinase C isozymes
    • Mahoney CW, Azzi A, Huang KP. Effects of suramin, an antihuman immunodeficiency virus reverse transcriptase agent, on protein kinase C: Differential activation and inhibition of protein kinase C isozymes. J Biol Chem. 1990;265:5424-5428.
    • (1990) J Biol Chem. , vol.265 , pp. 5424-5428
    • Mahoney, C.W.1    Azzi, A.2    Kp, H.3
  • 41
    • 0027733611 scopus 로고
    • Autoradiographic localization of tritiated suramin in polarized human colon adenocarcinoma cells
    • Baghdiguian S, Boudier JA, Boudier JL, Fantini J. Autoradiographic localization of tritiated suramin in polarized human colon adenocarcinoma cells. Cancer Lett. 1993;75:151-156.
    • (1993) Cancer Lett. , vol.75 , pp. 151-156
    • Baghdiguian, S.1    Boudier, J.A.2    Boudier, J.L.3    Fantini, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.