Risk Stratification for Failure in Patients with Advanced Cervical Cancer after Concurrent Chemoradiotherapy: Another Way to Optimise Treatment Results

Clinical Oncology

Volumn 20, Issue 9, 2008, Pages 683-690

  Liang, Ji An ^a,b   Chen, Shang Wen ^a,c   Chang, Wei Chun ^a,b   Hung, Yao Ching ^a,b   Yeh, Lian Shung ^a,b   Yang, Shih Neng ^a,b   Lin, Fang Jen ^a,b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cervical cancer; concurrent chemoradiotherapy; para aortic lymph node metastasis; predictive model; risk stratification

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BRACHYTHERAPY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG TREATMENT FAILURE; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GASTROINTESTINAL TOXICITY; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; PARAAORTIC LYMPH NODE; PELVIS LYMPH NODE; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE; RISK ASSESSMENT; RISK FACTOR; TREATMENT FAILURE; UTERINE CERVIX CANCER;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC AGENTS; BRACHYTHERAPY; CARCINOMA, SQUAMOUS CELL; CISPLATIN; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 52749087178     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2008.06.007     Document Type: Article

References (19)

1. Morris M., Eifel P.J., Lu J., et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 340 (1999) 1137-1143
2. Rose P.G., Bundy B.N., Watkins E.B., et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340 (1999) 1143-1153
3. Keys H.M., Bundy B.N., Stehman F.B., et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340 (1999) 1154-1161
4. Whitney C.W., Sause W., Bundy B.N., et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecology Oncology Group and Southwest Oncology Group study. J Clin Oncol 17 (1999) 1339-1348
5. Pearcey R., Brundage M., Drouin P., et al. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol 20 (2002) 966-972
6. Hong J.H., Tsai C.S., Lai C.H., et al. Risk stratification of patients with advanced squamous cell carcinoma of cervix treated by radiotherapy alone. Int J Radiat Oncol Biol Phys 63 (2005) 492-499
7. Stehman F.B., Bundy B.N., DiSaia P.J., Keys H.M., Larson J.E., and Fowler W.C. Carcinoma of the cervix treated with radiotherapy. I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer 67 (1991) 2776-2785
8. O'Hara K., Tanaka Y.O., Tsunoda H., et al. Nonoperative assessment of nodal status for locally advanced cell carcinoma treated by radiotherapy with regard to patterns of treatment failure. Int J Radiat Oncol Biol Phys 55 (2003) 354-361
9. Tsai C.S., Chang T.C., Lai C.H., et al. Preliminary report of using FDG-PET to detect extrapelvic lesions in cervical patients with enlarged pelvic lymph nodes on MRI/CT. Int J Radiat Oncol Biol Phys 58 (2004) 1506-1512
10. Stoeckli S.J., Mosna-Firlejczyk K., and Goerres G.W. Lymph node metastasis of squamous cell carcinoma from an unknown primary: impact of positron emission tomography. Eur J Nucl Med Mol Imaging 30 (2003) 411-416
11. Rotman M., Pajak T.F., Choi K., et al. Prophylatic extended-field irradiation of para-aortic lymph nodes in stage IIB and bulky IB and IIA cervical cancer: ten-year treatment results of RTOG 79-20. JAMA 275 (1995) 387-393
12. Eifel P.J., Winter K., Morris M., et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of RTOG 90-01 trial. J Clin Oncol 22 (2004) 872-880
13. International Commission on Radiation Units and Measurements. ICRU report 38: dose and volume specification for reporting intracavitary therapy in gynecology (1985), ICRU, Bethesda
14. Chen S.W., Liang J.A., Yeh L.S., Yang S.N., Shiau A.C., and Lin F.J. Comparative study of reference points by dosimetric analyses for late complications following uniform external radiotherapy and high-dose-rate brachytherapy for cervical cancer. Int J Radiat Oncol Biol Phys 60 (2004) 663-671
15. Petereit D.G., and Fowler J.F. High-dose-rate brachytherapy: high-dose, high-tech, and high-results. Int J Radiat Oncol Biol Phys 55 (2003) 1159-1161
16. Nakano T., Kato S., Ohno T., et al. Long-term results of high-dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix. Cancer 103 (2005) 92-101
17. Chen S.W., Liang J.A., Hung Y.C., et al. Concurrent weekly cisplatin plus external beam radiotherapy and high-dose rate brachytherapy for advanced cervical cancer: a control cohort comparison with radiation alone on treatment outcome and complications. Int J Radiat Oncol Biol Phys 66 5 (2006) 1370-1377
18. Grigsby P.W., Heydon K., Mutch D.G., Kim R.Y., and Eifel P. Long-term follow-up of RTOG 92-10: cervical cancer with positive para-aortic lymph nodes. Int J Radiat Oncol Biol Phys 51 (2001) 982-987
19. Grigsby P.W., Singh A.K., Siegel B.A., Dehdashti F., Rader J., and Zoberi I. Lymph node control in cervical cancer. Int J Radiat Oncol Biol Phys 59 (2004) 706-712