Microbicides 2008 conference: From discovery to advocacy

AIDS Research and Therapy

Volumn 5, Issue , 2008, Pages

  Ramjee, Gita ^a   Doncel, Gustavo F ^b   Mehendale, Sanjay ^c   Tolley, Elizabeth E ^d   Dickson, Kim ^e  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c NATIONAL AIDS RESEARCH INSTITUTE   (India)

^d FAMILY HEALTH INTERNATIONAL   (United States)

^e HTM/HIV Prevention in the Health Section   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARRAGEENAN; CELLACEFATE; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DAPIVIRINE; GEL 002; GLYCOPROTEIN GP 120 INHIBITOR; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; INTEGRASE INHIBITOR; MICROBICIDE; MIV 150; N [4 CHLORO 3 (3 METHYL 2 BUTENYLOXY)PHENYL] 2 METHYL 3 FURANCARBOTHIOAMIDE; PLACEBO; PRO 2000; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAVVY; TENOFOVIR; UNCLASSIFIED DRUG; VIVAGEL;

AFRICA SOUTH OF THE SAHARA; ANTIVIRAL ACTIVITY; BEHAVIOR MODIFICATION; CIRCUMCISION; CLINICAL TRIAL; COMMUNITY CARE; CULTURAL FACTOR; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENTIATION; DRUG RESEARCH; DRUG SAFETY; DRUG TOLERABILITY; HEALTH CARE ACCESS; HEALTH CARE QUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; INFECTION RATE; INFECTION RISK; MEDICAL ETHICS; MONOGAMY; NONHUMAN; PATIENT COMPLIANCE; PENIS DISEASE; PENIS DRYNESS; PENIS IRRITATION; PENIS PRURITUS; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SAFE SEX; SCROTUM DISORDER; SEXUAL BEHAVIOR; SEXUAL TRANSMISSION; SEXUALLY TRANSMITTED DISEASE; UNSPECIFIED SIDE EFFECT; VAGINA DISCHARGE; VAGINA RING; VIRUS ENTRY; VIRUS INHIBITION; VIRUS RESISTANCE;

EID: 52749086158     PISSN: 17426405     EISSN: None     Source Type: Journal    
DOI: 10.1186/1742-6405-5-19     Document Type: Review

References (68)

1. UNAIDS Press Release Global HIV prevalence has levelled off; AIDS is among the leading causes of death globally and remains the primary cause of death in Africa Geneva, Switzerland 20 November 2007
2. Padian NS Straten van der A Ramjee G Chipato T Blanchard K Shiboski S Montgomery ET Fancher H Cheng H Rosenblum M Laan van der M Jewell N McIntyre J MIRA Team Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: A randomized controlled trial Lancet 2007, 370:251-261 2442038 17631387 10.1016/S0140-6736(07)60950-7
3. FHI Joint statement on Savvy phase III trial in Ghana to test the effectiveness of Savvy gel in preventing HIV Durham, NC, USA 2005
4. FHI Phase III trial in Nigeria evaluating the effectiveness of Savvy gel in preventing HIV infection in women will close Durham, NC, USA 2005
5. Hartley O Fully recombinant chemokine analogues provide complete protection in the macaque vaginal challenge model Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 286
6. Herrera C Reverse transcriptase inhibitors as potential colorectal microbicides Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 498
7. Schader SM Better protection against HIV-1 infection in vitro with candidate microbicide compounds in combination Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 273
8. Trifonova RT Microbicide interference with TLR signaling in the presence of vaginal bacterial colonization Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 63
9. Patton DL Efficacy studies of a formulated octylglycerol lipid in the pigtailed macaque model: Trichomonas vaginalis and Chlamydia trachomatis Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 60
10. Denton PW Estes JD Sun Z Othieno FA Wei BL Wege AK Powell DA Payne D Haase AT Garcia JV Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice PLoS Med 2008, 5:e16 2194746 18198941 10.1371/journal.pmed.0050016
11. Mesquita PMM Wilson SS Manlow P Fischetti L Keller MJ Herold BC Shattock RJ Candidate Microbicide PPCM Blocks Human Immunodeficiency Virus Type 1 Infection in Cell and Tissue Cultures and Prevents Genital Herpes in a Murine Model Journal of Virology 2008, 82:6576-6584 10.1128/JVI.00335-08 18434407
12. Fuchs E Detecting rectal epithelial disruption using radioisotopes: A simple test to identify potential HIV microbicide toxicity Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 209
13. Lai BE Development of a novel in vitro assay to evaluate microbicide products in a layered, polarized configuration Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 561
14. HPTN 035 Webpage http://www.hptn.org/research_studies/hptn035.asp
15. MDP Webpage http://www.mdp.mrc.ac.uk/index.html
16. Luwugge H Adherence to gel and condom use among women participants in a phase III microbicide trial of PRO2000/5 in rural SW Uganda Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 329
17. Population Council Press Release Trial Shows Anti-HIV Microbicide is Safe, but Does Not Prove It Effective 18 February 2008. Johannesburg, South Africa and New York, USA
18. Gehret ML Male Partner Circumcision And HIV Seroconversion Among Participants In The Phase III Carraguard™ Microbicide Trial Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 414
19. Palanee T Incidence Of Sexually Transmitted And Reproductive Tract Infections Among Women Enrolled In The Phase III Carraguard™ Trial In South Africa Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 432
20. Gopolang FP A Comparison Between Self-Reported Condom Use And Presence Of Spermatozoa Using TV In pouch And Wet Mount, Among Women Enrolled In The Phase Iii Carraguard™ Clinical Trial In Cape Town Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 520
21. CAPRISA 004 Trial Information http://www.caprisa.org/Projects/ microbicides.html
22. Feldblum PJ Savvy (C31g) Vaginal Gel For Prevention Of HIV Infection: A Randomized Controlled Trial In Nigeria Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India http://clinicaltrials.gov/ct2/show/ NCT00130078 Abstract No. 142
23. Hillier SL Safety and acceptability of coitally dependant use of 1% tenofovir over six months of use Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 655
24. Das SS Strategies For Recruitment And Retention Of Women In The Hptn 059 Phase Ii Expanded Safety And Acceptability Study Of The Vaginal Microbicide 1% Tenofovir Gel In Pune, India Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India http://www.hptn.org/ research_studies/hptn059.asp Abstract No. 110
25. Smythe S Clinical Safety and Tolerability Assessment of an Anti-HIV Dapivirine Vaginal Microbicide Gel (Gel-002) Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India http://www.ipm-microbicides.org/clinical_activities/english/trials.htm Abstract No. 546
26. Nel A Coplan P Smythe S Douville K Romano J Mitchnick M Pharmacokinetic assessment of an Anti-HIV Dapivirine vaginal microbicide gel (Gel-002) Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 563
27. Lacey C Unacceptable Side Effects of a Hyperosmolar Vaginal Microbicide in a Phase I Trial Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 527
28. Price G SPL7013 Gel (Vivagel), a topical microbicide in development for prevention of HIV and genital herpes Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 213
29. Momanyi MK Menstrual cycle history taking - the challenge and lesson learned during conduct of a phase I microbicide (Vivagel) safety trial in Kisumu, Kenya Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 428
30. Anton PA A Phase I Safety and Acceptability Study Of The UC-781 Microbicide Gel Applied Rectally In HIV Seronegative Adults: An Interim Safety Report Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 290
31. Celum CL Effect Of HSV-2 Suppressive Therapy On Prevention Of HIV Acquisition (HPTN 039) Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 309
32. Watson-Jones D Weiss HA Rusizoka M Changalucha J Baisley K Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania N Engl J Med 2008, 358:1560-1571 10.1056/NEJMoa0800260 18337596
33. Straten Van der A Use of the diaphragm instead of condoms in the MIRA trial Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 413
34. Terris-Prestholt F Facilitating microbicide use in South Africa: Using women's preferences to design distribution strategies Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 247
35. Seshu M Not just participants recognizing the critical need for sex worker voices in microbicide research and development Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 419
36. Hilber AM Vaginal practices, microbicides, and HIV transmission - How important is the connection? Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 485
37. Foss AM Phasing introduction - what is the impact? Examination of potential microbicide introduction strategies in India Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 416
38. Ukpong MO Community vs researcher's perspectives on community demand from trials Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No.123
39. Wakasiaka SN Perceptions of health care providers regarding the acceptability of intra vaginal rings as a potential delivery method for microbicides Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 203
40. Hallad JS Early closure of a phase III microbicide clinical trial in south India: Implications on trial participants and clinical staff Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 475
41. Mbhele DL Impact of the pre-mature closure of the cellulose sulphate trial on enrolled participants in Durban Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No 526
42. Kalumbilo SN Issues affecting understanding of key informed consent messages in the MDP 301 trial in Mazabuka, Zambia Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 536
43. Corneli AL Socio-behavioral and community activities for an oral HIV prevention prep clinical trial: A multi-disciplinary approach Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 588
44. Mzimela AM Understanding the impact of trial participation on condom use among women in the MDP 301 clinical trial in the Umkhanyakude district of northern KwaZulu Natal Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 346
45. Tolley EE What predicts adherence in a safety trial - is it generalizable beyond the trial setting? Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 590
46. Dladla-Qwabe AN Factors affecting product adherence among HPTN 035 participants in Hlabisa Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 528
47. Mweemba O Partner involvement in gel use: The case of MDP trial participants in Zambia Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 442
48. Kawuma R Role of men in a phase III vaginal microbicide trial in SW Uganda Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 332
49. Seoka SP Cleansing, curing and exciting: Unanticipated attributes of a microbicide gel in the MDP 301 trial, South Africa Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 540
50. Dhookie J An assessment of the acceptability of PRO 2000/5 microbicide gel in the MDP 301 trial in Johannesburg Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 391
51. Montgomery C Emic perspectives on microbicides and sexual health: A new approach to acceptability Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 403
52. Musara P Motivation and practical constraints in secret use of microbicides in Harare, Zimbabwe Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 229
53. Carballo-Diéguez A Gel or suppositories? Results of a rectal microbicide preference trial Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No 210
54. Morrow K A contextual model of microbicide acceptability Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 557
55. Mansoor LE Development of materials and tools for the adherence support program in Caprisa 004 phase IIb tenofovir gel trial Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 497
56. Pool R Increasing the accuracy of adherence data in the microbicides development programme 301 trial Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 368
57. Ventuneac A Improving behavioral data collection with the use of state of the-art information technology tools Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 629
58. Abbott S Challenges implementing behavioral research in microbicides clinical trials Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 641
59. Ukpong M Community engagement in research concept development: Lessons from the Microbicides Trials Network (MTN) Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 88
60. Nakimuli M Community involvement in microbicide clinical trial through peer leader approach: Experiences from Makerere/Mulago/Conrad microbicide centre Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 326
61. Basajja V Strategies to recruit and retain couples in a vaginal microbicides trial of PRO2000/5 in a rural community, SW Uganda Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 333
62. Forbes A The missing chapter in the microbicide development strategy: Addressing the priority, gaps and barriers to full civil society engagement Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 577
63. Baron D Managing expectations and unexpected results. The role of the microbicides media and communication initiative (MMCI) Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 438
64. Watts C Apples and Oranges? Interpreting success from contraceptive and HIV prevention research Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 518
65. Pickett JW An International and multi-disciplinary approach to rectal microbicide advocacy Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 308
66. Haniff NZ Rectal microbicide advocacy and anal intercourse in a homophobic nation: The problems of the sexual act as sexual orientation Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 270
67. Brady M Building the platform for HIV prevention for adolescent girls Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 465
68. Binder L Vital Voices: HIV-positive women's involvement in microbicide development Microbicides 2008 Conference, 24-27 February 2008, New Delhi, India Abstract No. 353