No association between the ERBB3 gene and schizophrenia in a Japanese population

Neuroscience Research

Volumn 57, Issue 4, 2007, Pages 574-578

  Watanabe, Yuichiro ^a,b   Fukui, Naoki ^a   Nunokawa, Ayako ^a   Muratake, Tatsuyuki ^c   Kaneko, Naoshi ^a   Kitamura, Hideaki ^a   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Furumachi Mental Clinic   (Japan)

Author keywords

Case control study; ERBB3; Linkage disequilibrium; Neuregulin 1; Schizophrenia; Single nucleotide polymorphism

Indexed keywords

MESSENGER RNA; NEU DIFFERENTIATION FACTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; ERBB3 GENE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NRG1 GENE; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA;

ADULT; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; JAPAN; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ERBB-3; SCHIZOPHRENIA;

EID: 33947178068     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2007.01.001     Document Type: Article

References (44)

1. Aston C., Jiang L., and Sokolov B.P. Microarray analysis of postmortem temporal cortex from patients with schizophrenia. J. Neurosci. Res. 77 (2004) 858-866
2. Bakker S.C., Hoogendoorn M.L.C., Selten J.-P., Verduijn W., Pearson P.L., Sinke R.J., and Kahn R.S. Neuregulin 1: genetic support for schizophrenia subtypes. Mol. Psychiatry 9 (2004) 1061-1063
3. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
4. Buonanno A., and Fischbach G.D. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr. Opin. Neurobiol. 11 (2001) 287-296
5. Corfas G., Roy K., and Buxbaum J.D. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat. Neurosci. 7 (2004) 575-580
6. Corvin A.P., Morris D.W., McGhee K., Schwaiger S., Scully P., Quinn J., Meagher D., St Clair D., Waddington J.L., and Gill M. Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the neuregulin-1 locus. Mol. Psychiatry 9 (2004) 208-212
7. Duan J., Martinez M., Sanders A.R., Hou C., Krasner A.J., Schwartz D.B., and Gejman P.V. Neuregulin 1 (NRG1) and schizophrenia: analysis of a US family sample and the evidence in the balance. Psychol. Med. 35 (2005) 1-12
8. Erdfelder E., Faul F., and Buchner A. GPOWER: a general power analysis program. Behav. Res. Meth. Instrum. Comput. 28 (1996) 1-11
9. Falls D.L. Neuregulins: functions, forms, and signaling strategies. Exp. Cell Res. 284 (2003) 14-30
10. Fukui N., Muratake T., Kaneko N., Amagane H., and Someya T. Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population. Neurosci. Lett. 396 (2006) 117-120
11. Futamura T., Toyooka K., Iritani S., Niizato K., Nakamura R., Tsuchiya K., Someya T., Kakita A., Takahashi H., and Nawa H. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Mol. Psychiatry 7 (2002) 673-682
12. Gerlai R., Pisacane P., and Erickson S. Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav. Brain Res. 109 (2000) 219-227
13. Hahn C.-G., Wang H.-Y., Cho D.-S., Talbot K., Gur R.E., Berrettini W.H., Bakshi K., Kamins J., Borgmann-Winter K.E., Siegel S.J., Gallop R.J., and Arnold S.E. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat. Med. 12 (2006) 824-828
14. Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., Haroutunian V., and Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 4746-4751
15. Hall D., Gogos J.A., and Karayiorgou M. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Genes Brain Behav. 3 (2004) 240-248
16. Hashimoto R., Straub R.E., Weikert C.S., Hyde T.M., Kleinman J.E., and Weinberger D.R. Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol. Psychiatry 9 (2004) 299-307
17. Hirakawa M., Tanaka T., Hashimoto Y., Kuroda M., Takagi T., and Nakamura Y. JSNP: a database of common gene variations in the Japanese population. Nucl. Acids Res. 30 (2002) 158-162
18. Hong C.-J., Huo S.-J., Liao D.-L., Lee K., Wu J.-Y., and Tsai S.-J. Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neurosci. Lett. 366 (2004) 158-161
19. Iwata N., Suzuki T., Ikeda M., Kitajima T., Yamanouchi Y., Inada T., and Ozaki N. No association with the neuregulin 1 haplotype to Japanese schizophrenia. Mol. Psychiatry 9 (2004) 126-127
20. Kanazawa T., Glatt S.J., Tsutsumi A., Kikuyama H., Koh J., Yoneda H., and Tsuang M.T. Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 144B (2007) 113-116
21. Ke X., and Cardon L.R. Efficient selective screening of haplotype tag SNPs. Bioinformatics 19 (2003) 287-288
22. Kishi T., Ikeda M., Suzuki T., Kitajima T., Yamanouchi Y., Kinoshita Y., Ozaki N., and Iwata N. No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population. Schizophr. Res. 82 (2006) 185-189
23. Lachman H.M., Pedrosa E., Nolan K.A., Glass M., Ye K., and Saito T. Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 141B (2006) 102-109
24. Law A.J., Lipska B.K., Weickert C.S., Hyde T.M., Straub R.E., Hashimoto R., Harrison P.J., Kleinman J.E., and Weinberger D.R. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 6747-67552
25. Li D., Collier D.A., and He L. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum. Mol. Genet. 15 (2006) 1995-2002
26. Li T., Stefansson H., Gudfinnsson E., Cai G., Liu X., Murray R.M., Steinthorsdottir V., Januel D., Gudnadottir V.G., Petursson H., Ingason A., Gulcher J.R., Stefansson K., and Collier D.A. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Mol. Psychiatry 9 (2004) 698-704
27. Munafò M.R., Thiselton D.L., Clark T.G., and Flint J. Association of the NRG1 gene and schizophrenia: a meta-analysis. Mol. Psychiatry 11 (2006) 539-546
28. Nawa H., Takahashi M., and Patterson P.H. Cytokine and growth factor involvement in schizophrenia-support for the developmental model. Mol. Psychiatry 5 (2000) 594-603
29. Nawa H., and Takei N. Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines. Neurosci. Res. 56 (2006) 2-13
30. Norton N., Moskvina V., Morris D.W., Bray N.J., Zammit S., Williams N.M., Williams H.J., Preece A.C., Dwyer S., Wilkinson J.C., Spurlock G., Kirov G., Buckland P., Waddington J.L., Gill M., Corvin A.P., Owen M.J., and O'Donovan M.C. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 141B (2006) 96-101
31. Nyholt D.R. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Hum. Genet. 74 (2004) 765-769
32. Petryshen T.L., Middleton F.A., Kirby A., Aldinger K.A., Purcell S., Tahl A.R., Morley C.P., McGann L., Gentile K.L., Rockwell G.N., Medeiros H.M., Carvalho C., Macedo A., Dourado A., Valente J., Ferreira C.P., Patterson N.J., Azevedo M.H., Daly M.J., Pato C.N., Pato M.T., and Sklar P. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Mol. Psychiatry 10 (2005) 366-374
33. Sastry P.S.R.K., and Ratna W.S. Intrathecal therapy with trastuzumab may be beneficial in cases of refractory schizophrenia. Med. Hypotheses 62 (2004) 542-545
34. Silberberg G., Darvasi A., Pinkas-Kramarski R., and Navon R. The involvement of ErbB4 with schizophrenia: association and expression studies. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 141B (2006) 142-148
35. Stefansson H., Sarginson J., Kong A., Yates P., Steinthorsdottir V., Gudfinnsson E., Gunnarsdottir S., Walker N., Petursson H., Crombie C., Ingason A., Gulcher J.R., Stefansson K., and St Clair D. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am. J. Hum. Genet. 72 (2003) 83-87
36. Stefansson H., Sigurdsson E., Steinthorsdottir V., Bjornsdottir S., Sigmundsson T., Ghosh S., Brynjolfsson J., Gunnarsdottir S., Ivarsson O., Chou T.T., Hjaltason O., Birgisdottir B., Jonsson H., Gudnadottir V.G., Gudmundsdottir E., Bjornsson A., Ingvarsson B., Ingason A., Sigfusson S., Hardardottir H., Harvey R.P., Lai D., Zhou M., Brunner D., Mutel V., Gonzalo A., Lemke G., Sainz J., Johannesson G., Andresson T., Gudbjartsson D., Manolescu A., Frigge M.L., Gurney M.E., Kong A., Gulcher J.R., Petursson H., and Stefansson K. Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71 (2002) 877-892
37. Tang J.X., Chen W.Y., He G., Zhou J., Gu N.F., Feng G.Y., and He L. Polymorphisms within 5′ end of the neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population. Mol. Psychiatry 9 (2004) 11-13
38. Thiselton D.L., Webb B.T., Neale B.M., Ribble R.C., O'Neill F.A., Walsh D., Riley B.P., and Kendler K.S. No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). Mol. Psychiatry 9 (2004) 777-783
39. Tkachev D., Mimmack M.L., Ryan M.M., Wayland M., Freeman T., Jones P.B., Starkey M., Webster M.J., Yolken R.H., and Bahn S. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362 (2003) 798-805
40. Walss-Bass C., Liu W., Lew D.F., Villegas R., Montero P., Dassori A., Leach R.J., Almasy L., Escamilla M., and Raventos H. A novel missense mutation in the transmembrane domain of neuregulin 1 is associated with schizophrenia. Biol. Psychiatry 60 (2006) 548-553
41. Watanabe Y., Fukui N., Muratake T., Amagane H., Kaneko N., Nunokawa A., and Someya T. Association study of a functional promoter polymorphism of the X-box binding protein 1 (XBP1) gene in Japanese patients with schizophrenia. Psychiatry Clin. Neurosci. 60 (2006) 633-635
42. Williams N.M., Preece A., Spurlock G., Norton N., Williams H.J., Zammit S., O'Donovan M.C., and Owen M.J. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol. Psychiatry 8 (2003) 485-487
43. Yang J.Z., Si T.M., Ruan Y., Ling Y.S., Han Y.H., Wang X.L., Zhou M., Zhang H.Y., Kong Q.M., Liu C., Zhang D.R., Yu Y.Q., Liu S.Z., Ju G.Z., Shu L., Ma D.L., and Zhang D. Association study of neuregulin 1 gene with schizophrenia. Mol. Psychiatry 8 (2003) 706-709
44. Zhao X., Shi Y., Tang J., Yu L., Gu N., Feng G., Zhu S., Liu H., Xing Y., Zhao S., Sang H., Guan Y., St Clair D., and He L. A case control and family based association study of the neuregulin1 gene and schizophrenia. J. Med. Genet. 41 (2004) 31-34