Targeting Tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes

Journal of Virology

Volumn 82, Issue 19, 2008, Pages 9492-9504

  D'Orso, Iván ^a   Grunwell, Jocelyn R ^a   Nakamura, Robert L ^b   Das, Chandreyee ^a,c   Frankel, Alan D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Advanced Genetic Systems   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; HOLOENZYME; MESSENGER RNA; PROTEIN INHIBITOR; RNA POLYMERASE II; SERINE; TRANSACTIVATOR PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RNA PROCESSING; VIRUS ASSEMBLY; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

AMINO ACID SEQUENCE; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; HELA CELLS; HIV-1; HUMANS; KINETICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 52649144324     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00763-08     Document Type: Article

References (54)

1. Ahn, S. H., M. Kim, and S. Buratowski. 2004. Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3′ end processing. Mol. Cell 13:67-76.
2. Bentley, D. L. 2005. Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors. Curr. Opin. Cell Biol. 17:251-256.
3. Boehm, A. K., A. Saunders, J. Werner, and J. T. Lis. 2003. Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock. Mol. Cell. Biol. 23:7628-7637.
4. Brady, J., and F. Kashanchi. 2005. Tat gets the "green" light on transcription initiation. Retrovirology 2:69.
5. Brès, V., N. Gomes, L. Pickle, and K. A. Jones. 2005. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev. 19:1211-1226.
6. Caputo, A., M. P. Grossi, R. Bozzini, C. Rossi, M. Betti, P. C. Marconi, G. Barbanti-Brodano, and P. G. Balboni. 1996. Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region. Gene Ther. 3:235-245.
7. Carroll, R., B. M. Peterlin, and D. Derse. 1992. Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators. J. Virol. 66:2000-2007.
8. Cramer, P. 2004. RNA polymerase II structure: from core to functional complexes. Curr. Opin. Genet. Dev. 14:218-226.
9. Cujec, T. P., H. Cho, E. Maldonado, J. Meyer, D. Reinberg, and B. M. Peterlin. 1997. The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. Mol. Cell. Biol. 17:1817-1823.
10. Das, R., J. Yu, Z. Zhang, M. P. Gygi, A. R. Krainer, S. P. Gygi, and R. Reed. 2007. SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Mol. Cell 26:867-881.
11. Fong, N., G. Bird, M. Vigneron, and D. L. Bentley. 2003. A 10 residue motif at the C-terminus of the RNA pol II CTD is required for transcription, splicing and 3′ end processing. EMBO J. 22:4274-4282.
12. Fraisier, C., D. A. Abraham, M. van Oijen, V. Cunliffe, A. Irvine, R. Craig, and E. A. Dzierzak. 1998. Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins. Gene Ther. 5:946-954.
13. Friedman, A. D., S. J. Triezenberg, and S. L. McKnight. 1988. Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus. Nature 335:452-454.
14. Gama-Carvalho, M., R. D. Krauss, L. Chiang, J. Valcarcel, M. R. Green, and M. Carmo-Fonseca. 1997. Targeting of U2AF65 to sites of active splicing in the nucleus. J. Cell Biol. 137:975-987.
15. Garber, M. E., P. Wei, V. N. KewalRamani, T. P. Mayall, C. H. Herrmann, A. P. Rice, D. R. Littman, and K. A. Jones. 1998. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev. 12:3512-3527.
16. Gerber, H. P., M. Hagmann, K. Seipel, O. Georgiev, M. A. West, Y. Litingtung, W. Schaffner, and J. L. Corden. 1995. RNA polymerase II C-terminal domain required for enhancer-driven transcription. Nature 374:660-662.
17. Gill, G., and M. Ptashne. 1988. Negative effect of the transcriptional activator GAL4. Nature 334:721-724.
18. Gomes, N. P., G. Bjerke, B. Llorente, S. A. Szostek, B. M. Emerson, and J. M. Espinosa. 2006. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev. 20:601-612.
19. Green, M., M. Ishino, and P. M. Loewenstein. 1989. Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression. Cell 58:215-223.
20. Hahn, S. 2004. Structure and mechanism of the RNA polymerase II transcription machinery. Nat. Struct. Mol. Biol. 11:394-403.
21. Herskowitz, I. 1987. Functional inactivation of genes by dominant negative mutations. Nature 329:219-222.
22. Hertel, K. J., and B. R. Graveley. 2005. RS domains contact the pre-mRNA throughout spliceosome assembly. Trends Biochem. Sci. 30:115-118.
23. Kim, B., A. I. Nesvizhskii, P. G. Rani, S. Hahn, R. Aebersold, and J. A. Ranish. 2007. The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes. Proc. Natl. Acad. Sci. USA 104:16068-16073.
24. Komarnitsky, P., E. J. Cho, and S. Buratowski. 2000. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev. 14:2452-2460.
25. Kornblihtt, A. R., M. de la Mata, J. P. Fededa, M. J. Munoz, and G. Nogues. 2004. Multiple links between transcription and splicing. RNA 10:1489-1498.
26. Landt, S. G., R. Tan, and A. D. Frankel. 2000. Screening RNA-binding libraries using Tat-fusion system in mammalian cells. Methods Enzymol. 318:350-363.
27. Lassen, K., Y. Han, Y. Zhou, J. Siliciano, and R. F. Siliciano. 2004. The multifactorial nature of HIV-1 latency. Trends Mol. Med. 10:525-531.
28. Luecke, H. F., and K. R. Yamamoto. 2005. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 19:1116-1127.
29. Mabon, S. A., and T. Misteli. 2005. Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. PLoS Biol. 3:e374.
30. Minton, A. P. 2000. Implications of macromolecular crowding for protein assembly. Curr. Opin. Struct. Biol. 10:34-39.
31. Misteli, T. 2007. Beyond the sequence: cellular organization of genome function. Cell 128:787-800.
32. Misteli, T., and D. L. Spector. 1999. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol. Cell 3:697-705.
33. Orsini, M. J., and C. M. Debouck. 1996. Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm. J. Virol. 70:8055-8063.
34. Pan, G., T. Aso, and J. Greenblatt. 1997. Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. J. Biol. Chem. 272:24563-24571.
35. Pearson, L., J. Garcia, F. Wu, N. Modesti, J. Nelson, and R. Gaynor. 1990. A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat. Proc. Natl. Acad. Sci. USA 87:5079-5083.
36. Peled-Zehavi, H., J. A. Berglund, M. Rosbash, and A. D. Frankel. 2001. Recognition of RNA branch point sequences by the KH domain of splicing factor 1 (mammalian branch point binding protein) in a splicing factor complex. Mol. Cell. Biol. 21:5232-5241.
37. Peterlin, B. M., and D. H. Price. 2006. Controlling the elongation phase of transcription with P-TEFb. Mol. Cell 23:297-305.
38. Plavec, I., M. Agarwal, K. E. Ho, M. Pineda, J. Auten, J. Baker, H. Matsuzaki, S. Escaich, M. Bonyhadi, and E. Bohnlein. 1997. High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS. Gene Ther. 4:128-139.
39. Ptashne, M., and A. Gann. 1998. Imposing specificity by localization: mechanism and evolvability. Curr. Biol. 8:R812-R822.
40. Raha, T., S. W. Cheng, and M. R. Green. 2005. HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs. PLoS Biol. 3:e44.
41. Reed, R., and E. Hurt. 2002. A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell 108:523-531.
42. Robert, F., M. Blanchette, O. Maes, B. Chabot, and B. Coulombe. 2002. A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly. J. Biol. Chem. 277:9302-9306.
43. Selby, M. J., and B. M. Peterlin. 1990. Trans-activation by HIV-1 Tat via a heterologous RNA binding protein. Cell 62:769-776.
44. Shamah, S. M., and C. D. Stiles. 1995. Transdominant negative mutations. Methods Enzymol. 254:565-576.
45. Southgate, C., M. L. Zapp, and M. R. Green. 1990. Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. Nature 345:640-642.
46. Szak, S. T., D. Mays, and J. A. Pietenpol. 2001. Kinetics of p53 binding to promoter sites in vivo. Mol. Cell. Biol. 21:3375-3386.
47. Tan, R., and A. D. Frankel. 1998. A novel glutamine-RNA interaction identified by screening libraries in mammalian cells. Proc. Natl. Acad. Sci. USA 95:4247-4252.
48. Trono, D., M. B. Feinberg, and D. Baltimore. 1989. HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 59:113-120.
49. Ujvári, A., and D. S. Luse. 2004. Newly initiated RNA encounters a factor involved in splicing immediately upon emerging from within RNA polymerase II. J. Biol. Chem. 279:49773-49779.
50. Valcárcel, J., R. K. Gaur, R. Singh, and M. R. Green. 1996. Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA. Science 273:1706-1709.
51. Verhoef, K., M. Koper, and B. Berkhout. 1997. Determination of the minimal amount of Tat activity required for human immunodeficiency virus type 1 replication. Virology 237:228-236.
52. Weinberger, L. S., J. C. Burnett, J. E. Toettcher, A. P. Arkin, and D. V. Schaffer. 2005. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell 122:169-182.
53. Williams, S. A., L. F. Chen, H. Kwon, C. M. Ruiz-Jarabo, E. Verdin, and W. C. Greene. 2006. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 25:139-149.
54. Xie, B., M. A. Wainberg, and A. D. Frankel. 2003. Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions. J. Virol. 77:1984-1991.