Fispemifene [Z-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}- ethanol], a novel selective estrogen receptor modulator, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis

Journal of Pharmacology and Experimental Therapeutics

Volumn 327, Issue 1, 2008, Pages 58-67

  Yatkin, Emrah ^a,b   Bernoulli, Jenni ^a   Lammintausta, Risto ^c,d   Santti, Risto ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ISTANBUL UNIVERSITY   (Turkey)

^c Hormos Medical Ltd   (Finland)

^d Subsidiary of QuatrX Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FISPEMIFENE; PROGESTERONE RECEPTOR; PROLACTIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TESTOSTERONE; TRANSCRIPTION FACTOR FRA 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CASTRATION; CHRONIC PROSTATITIS; CONTROLLED STUDY; ENZYME IMMUNOASSAY; HISTOLOGY; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; MALE; NOBLE RAT; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROSTATITIS; RAT; SEMINAL VESICLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGEN ANTAGONISTS; FOS-RELATED ANTIGEN-2; IMMUNOHISTOCHEMISTRY; MALE; ORGAN SIZE; PROLACTIN; PROSTATITIS; RATS; RECEPTORS, PROGESTERONE; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; TESTOSTERONE;

EID: 52649124903     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.139501     Document Type: Article

References (37)

1. Ackerman LS (2006) Sex hormones and the genesis of autoimmunity. Arch Dermatol 142:371-376.
2. Bernoulli J, Yatkin E, Laakso A, Anttinen M, Bosland M, Vega K, Kallajoki M, Santti R, and Pylkkänen L (2008) Histopathological evidence for an association of inflammation with ductal pin-like lesions but not with ductal adenocarcinoma in the prostate of the noble rat. Prostate 68:728-739.
3. Bernoulli J, Yatkin E, Talvitie EM, Santti R, and Streng T (2007) Urodynamic changes in a noble rat model for nonbacterial prostatic inflammation. Prostate 67:888-899.
4. Bianco JJ, Handelsman DJ, Pedersen JS, and Risbridger GP (2002) Direct response of the murine prostate gland and seminal vesicles to estradiol. Endocrinology 143:4922-4933.
5. Blumenfeld W, Tucci S, and Narayan P (1992) Incidental lymphocytic prostatitis: selective involvement with nonmalignant glands. Am J Surg Pathol 16:975-981.
6. Bosland MC, Ford H, and Horton L (1995) Induction at high incidence of ductal prostate adenocarcinomas in NBL/cr and Sprague-Dawley Hsd:SD rats treated with a combination of testosterone and estradiol-17 beta or diethylstilbestrol. Carcinogenesis 16:1311-1317.
7. Collins MM, Meigs JB, Barry MJ, Walker Corkery E, Giovannucci E, and Kawachi I (2002) Prevalence and correlates of prostatitis in the health professionals follow-up study cohort. J Urol 167:1363-1366.
8. Curtis Nickel J, Baranowski AP, Pontari M, Berger RE, and Tripp DA (2007) Management of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome who have failed traditional management. Rev Urol 9:63-72.
9. Fitts JM, Klein RM, and Powers CA (2004) Comparison of tamoxifen and testosterone propionate in male rats: differential prevention of orchidectomy effects on sex organs, bone mass, growth, and the growth hormone-IGF-i axis. J Androl 25:523-534.
10. Howell A and Abram P (2005) Clinical development of fulvestrant ("faslodex"). Cancer Treat Rev 31 (Suppl 2):S3-S9.
11. Irani J, Levillain P, Goujon JM, Bon D, Doré B, and Aubert J (1997) Inflammation in benign prostatic hyperplasia: correlation with prostate specific antigen value. J Urol 157:1301-1303.
12. Karlsson S (2006) Histopathology and histomorphometry of the urogenital tract in 15-month old male and female rats treated neonatally with SERMs and estrogens. Exp Toxicol Pathol 58:1-12.
13. Keetch DW, Humphrey P, and Ratliff TL (1994) Development of a mouse model for nonbacterial prostatitis. J Urol 152:247-250.
14. Kindblom J, Dillner K, Sahlin L, Robertson F, Ormandy C, Törnell J, and Wennbo H (2003) Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin. Endocrinology 144:2269-2278.
15. Kohnen PW and Drach GW (1979) Patterns of inflammation in prostatic hyperplasia: a histologic and bacteriologic study. J Urol 121:755-760.
16. Leav I, Merk FB, Kwan PW, and Ho SM (1989) Androgen-supported estrogen-enhanced epithelial proliferation in the prostates of intact noble rats. Prostate 15:23-40.
17. Levine R and Levine S (1989) Role of the pituitary-adrenal hormones in the acquisition of schedule-induced polydipsia. Behav Neurosci 103:621-637.
18. Lyle SF, Wright K, and Collins DC (1984) Comparative effects of tamoxifen and bromocriptine on prolactin and pituitary weight in estradiol-treated male rats. Cancer 53:1473-1477.
19. McPherson SJ, Wang H, Jones ME, Pedersen J, Iismaa TP, Wreford N, Simpson ER, and Risbridger GP (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142:2458-2467.
20. Motrich RD, Maccioni M, Riera CM, and Rivero VE (2007) Autoimmune prostatitis: state of the art. Scand J Immunol 66:217-227.
21. Naslund MJ, Strandberg JD, and Coffey DS (1988) The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis. J Urol 140:1049-1053.
22. Nellemann C, Dalgaard M, Holst B, Bonefeld-Jørgensen EC, and Vinggaard AM (2005) Gene expression changes in rat prostate after activation or blocking of the androgen and estrogen receptor. Mol Cell Endocrinol 237:25-35.
23. Nickel JC, True LD, Krieger JN, Berger RE, Boag AH, and Young ID (2001) Consensus development of a histopathological classification system for chronic prostatic inflammation. BJU Int 87:797-805.
24. Orgebin-Crist MC, Eller BC, and Danzo BJ (1983) The effects of estradiol, tamoxifen, and testosterone on the weights and histology of the epididymis and accessory sex organs of sexually immature rabbits. Endocrinology 113:1703-1715.
25. Risbridger G, Wang H, Young P, Kurita T, Wang YZ, Lubahn D, Gustafsson JA, and Cunha G(2001) Evidence that epithelial and mesenchymal estrogen receptoralpha mediates effects of estrogen on prostatic epithelium. Dev Biol 229:432-442.
26. Robinette CL (1988) Sex-hormone-induced inflammation and fibromuscular proliferation in the rat lateral prostate. Prostate 12:271-286.
27. Rudick CN, Schaeffer AJ, and Thumbikat P (2008) Experimental autoimmune prostatitis induces chronic pelvic pain. Am J Physiol Regul Integr Comp Physiol 294:R1268-R1275.
28. Sciarra A, Mariotti G, Salciccia S, Gomez AA, Monti S, Toscano V, and Di Silverio F (2008) Prostate growth and inflammation. J Steroid Biochem Mol Biol 108:254-260.
29. Straub RH (2007) The complex role of estrogens in inflammation. Endocr Rev 28:521-574.
30. Taguchi O (1987) Reproductive tract lesions in male mice treated neonatally with tamoxifen. Biol Reprod 37:113-116.
31. Tangbanluekal L and Robinette CL (1993) Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats. Endocrinology 132:2407-2416.
32. Thompson CJ, Tam NN, Joyce JM, Leav I, and Ho SM (2002) Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780. Endocrinology 143:2093-2105.
33. Thorat SP, Thatte UM, Pai N, and Dahanukar SA (1993) Effect of prolactin on neutrophils and monocytes. Acta Haematol 89:219-220.
34. Tibbetts TA, Conneely OM, and O'Malley BW (1999) Progesterone via its receptor antagonizes the pro-inflammatory activity of estrogen in the mouse uterus. Biol Reprod 60:1158-1165.
35. Vykhovanets EV, Resnick MI, MacLennan GT, and Gupta S (2007) Experimental rodent models of prostatitis: limitations and potential. Prostate Cancer Prostatic Dis 10:15-29.
36. Vykhovanets EV, Resnick MI, and Marengo SR (2006) Intraprostatic lymphocyte profiles in aged Wistar rats with estradiol induced prostate inflammation. J Urol 175:1534-1540.
37. West NB, Chang CS, Liao SS, and Brenner RM (1990) Localization and regulation of estrogen, progestin and androgen receptors in the seminal vesicle of the rhesus monkey. J Steroid Biochem Mol Biol 37:11-21.