4-O-acetylation and 3-O-acetylation of trichothecenes by trichothecene 15-O-acetyltransferase encoded by Fusarium Tri3

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 9, 2008, Pages 2485-2489

  Tokai, Takeshi ^a,d,e   Takahashi Ando, Naoko ^a,d   Izawa, Masumi ^a,b   Kamakura, Takashi ^b   Yoshida, Minoru ^c   Fujimura, Makoto ^d   Kimura, Makoto ^a,c  

^a Japan Science and Technology Agency   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c RIKEN   (Japan)

^d TOYO UNIVERSITY   (Japan)

^e TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Biosynthesis gene cluster; Fungal secondary metabolism; Fusarium graminearum (Gibberella zeae); Sesquiterpene; Trichothecene mycotoxins

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CHLORINE COMPOUNDS; CONCENTRATION (PROCESS); ENZYME ACTIVITY; FOOD ADDITIVES; GENES;

ACETYL TRANSFERASES; ACETYLATED DERIVATIVES; ACETYLTRANSFERASE ACTIVITY; BIOSYNTHESIS GENE CLUSTER; DIACETYLNIVALENOL; ENZYME CONCENTRATIONS; EVOLUTIONARY HISTORY; FUNGAL SECONDARY METABOLISM; FUSARIUM; FUSARIUM GRAMINEARUM (GIBBERELLA ZEAE); GAIN INSIGHT; GENE CLUSTERING; H IGH CONCENTRATIONS; HYDROXYL GROUPS; NIVALENOL; O-ACETYLATION; PATHWAY GENES; SESQUITERPENE; TRICHOTHECENE; TRICHOTHECENE MYCOTOXINS; TRICHOTHECENES;

ACETYLATION;

ACYLTRANSFERASE; FUNGAL PROTEIN; RECOMBINANT PROTEIN; TRI3 PROTEIN, FUSARIUM; TRICHOTHECENE DERIVATIVE;

ACETYLATION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; FUSARIUM; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MULTIGENE FAMILY;

ACETYLATION; ACETYLTRANSFERASES; FUNGAL PROTEINS; FUSARIUM; MOLECULAR STRUCTURE; MULTIGENE FAMILY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRICHOTHECENES;

FUSARIUM; GIBBERELLA; GIBBERELLA ZEAE;

EID: 52649104989     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80501     Document Type: Article

References (23)

1. Walton, J. D., Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: an hypothesis. Fungal Genet. Biol., 30, 167-171 (2000).
2. Ahn, J. H., Cheng, Y. Q., and Walton, J. D., An extended physical map of the TOX2 locus of Cochliobolus carbonum required for biosynthesis of HC-toxin. Fungal Genet. Biol., 35, 31-38 (2002).
3. Turgeon, B. G., and Baker, S. E., Genetic and genomic dissection of the Cochliobolus heterostrophus Tox1 locus controlling biosynthesis of the polyketide virulence factor T-toxin. Adv. Genet., 57, 219-261 (2007).
4. Kimura, M., Tokai, T., O'Donnell, K., Ward, T. J., Fujimura, M., Hamamoto, H., Shibata, T., and Yamaguchi, I., The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes. FEBS Lett., 539, 105-110 (2003).
5. Brown, D. W., Dyer, R. B., McCormick, S. P., Kendra, D. F., and Plattner, R. D., Functional demarcation of the Fusarium core trichothecene gene cluster. Fungal Genet. Biol., 41, 454-462 (2004).
6. Kimura, M., Kaneko, I., Komiyama, M., Takatsuki, A., Koshino, H., Yoneyama, K., and Yamaguchi, I., Trichothecene 3-O-acetyltransferase protects both the producing organism and transformed yeast from related mycotoxins. Cloning and characterization of Tri101. J. Biol. Chem., 273, 1654-1661 (1998).
7. McCormick, S. P., Alexander, N. J., Trapp, S. E., and Hohn, T. M., Disruption of TRI101, the gene encoding trichothecene 3-O-acetyltransferase, from Fusarium sporotrichioides. Appl. Environ. Microbiol., 65, 5252-5256 (1999).
8. O'Donnell, K., Kistler, H. C., Tacke, B. K., and Casper, H. H., Gene genealogies reveal global phylogeographic structure and reproductive isolation among lineages of Fusarium graminearum, the fungus causing wheat scab. Proc. Natl. Acad. Sci. USA, 97, 7905-7910 (2000).
9. Kimura, M., Matsumoto, G., Shingu, Y., Yoneyama, K., and Yamaguchi, I., The mystery of the trichothecene 3-O-acetyltransferase gene. Analysis of the region around Tri101 and characterization of its homologue from Fusarium sporotrichioides. FEBS Lett., 435, 163-168 (1998).
10. Kimura, M., Tokai, T., Matsumoto, G., Fujimura, M., Hamamoto, H., Yoneyama, K., Shibata, T., and Yamaguchi, I., Trichothecene nonproducer Gibberella species have both functional and nonfunctional 3-O-acetyltransferase genes. Genetics, 163, 677-684 (2003).
11. Tokai, T., Fujimura, M., Inoue, H., Aoki, T., Ohta, K., Shibata, T., Yamaguchi, I., and Kimura, M., Concordant evolution of trichothecene 3-O-acetyltransferase and an rDNA species phylogeny of trichothecene-producing and non-producing fusaria and other ascomycetous fungi. Microbiology, 151, 509-519 (2005).
12. McCormick, S. P., Hohn, T. M., and Desjardins, A. E., Isolation and characterization of Tri3, a gene encoding 15-O-acetyltransferase from Fusarium sporotrichioides. Appl. Environ. Microbiol., 62, 353-359 (1996).
13. Brown, D. W., McCormick, S. P., Alexander, N. J., Proctor, R. H., and Desjardins, A. E., A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. Fungal Genet. Biol., 32, 121-133 (2001).
14. O'Donnell, K., Ward, T. J., Geiser, D. M., Kistler, H. C., and Aoki, T., Genealogical concordance between the mating type locus and seven other nuclear genes supports formal recognition of nine phylogenetically distinct species within the Fusarium graminearum clade. Fungal Genet. Biol., 41, 600-623 (2004).
15. Tokai, T., Koshino, H., Kawasaki, T., Igawa, T., Suzuki, Y., Sato, M., Fujimura, M., Eizuka, T., Watanabe, H., Kitahara, T., Ohta, K., Shibata, T., Kudo, T., Inoue, H., Yamaguchi, I., and Kimura, M., Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis. FEMS Microbiol. Lett., 251, 193-201 (2005).
16. Igawa, T., Ochiai-Fukuda, T., Takahashi-Ando, N., Ohsato, S., Shibata, T., Yamaguchi, I., and Kimura, M., New TAXI-type xylanase inhibitor genes are inducible by pathogens and wounding in hexaploid wheat. Plant Cell Physiol., 45, 1347-1360 (2004).
17. Takitani, S., Asabe, Y., Kato, T., Suzuki, M., and Ueno, Y., Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J. Chromatogr., 172, 335-342 (1979).
18. Thibault, G., Guitard, M., and Daigneault, R., A study of the enzymatic inactivation of chloramphenicol by highly purified chloramphenicol acetyltransferase. Biochim. Biophys. Acta, 614, 339-342 (1980).
19. Alexander, N. J., McCormick, S. P., and Hohn, T. M., The identification of the Saccharomyces cerevisiae gene AYT1(ORF-YLL063c) encoding an acetyltransferase. Yeast, 19, 1425-1430 (2002).
20. Kimura, M., Tokai, T., Takahashi-Ando, N., Ohsato, S., and Fujimura, M., Molecular and genetic studies of Fusarium trichothecene biosynthesis: pathways, genes, and evolution. Biosci. Biotechnol. Biochem., 71, 2105-2123 (2007).
21. Lee, T., Han, Y. K., Kim, K. H., Yun, S. H., and Lee, Y. W., Tri13 and Tri7 determine deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae. Appl. Environ. Microbiol., 68, 2148-2154 (2002).
22. Sweigard, J. A., Carroll, A. M., Kang, S., Farrall, L., Chumley, F. G., and Valent, B., Identification, cloning, and characterization of PWL2, a gene for host species specificity in the rice blast fungus. Plant Cell, 7, 1221-1233 (1995).
23. Keller, N. P., Turner, G., and Bennett, J. W., Fungal secondary metabolism - from biochemistry to genomics. Nat. Rev. Microbiol., 3, 937-947 (2005).