Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 295, Issue 3, 2008, Pages

  Liu, Y ^a   Fanburg, B L ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

Cell signal transduction; Phosphatidic acid; Phospholipase D; Pulmonary artery smooth muscle cell proliferation; Serotonin

Indexed keywords

BUTANOL; CYCLIN D1; IMIPRAMINE; KETANSERIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDIC ACID; PHOSPHATIDYLBUTANOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; PROTEIN S6; RHO FACTOR; S6 KINASE; SEROTONIN; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG; PHOSPHOLIPASE D1; RECOMBINANT PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; LIPID HYDROLYSIS; MITOGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR CAPACITY; ANIMAL; BIOLOGICAL MODEL; CATTLE; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; METABOLISM;

ANIMALS; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; HUMANS; MODELS, BIOLOGICAL; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; PULMONARY ARTERY; RECEPTOR, SEROTONIN, 5-HT2A; RECOMBINANT PROTEINS; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 52649100665     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00071.2008     Document Type: Article

References (34)

1. Abdelghaffar H, Vazifeh D, Labro MT. Erythromycin A-derived macrolides modify the functional activities of human neutrophils by altering the phospholipase D-phosphatidate phosphohydrolase transduction pathway: L-cladinose is involved both in alterations of neutrophil functions and modulation of this transductional pathway. J Immunol 159: 3995-4005, 1997.
2. Adnot S, Eddahibi S. Genetics and physiopathology of primary or secondary pulmonary artery hypertension. Bull Acad Natl Med 187: 1529-1525, 2003.
3. Cummings R, Parinandi N, Wang L, Usatyuk P, Natarajan V. Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung. Mol Cell Biochem 234-235: 99-109, 2002.
4. Eddahibi S, Adnot S. Serotonin and pulmonary arterial hypertension. Rev Mal Respir 99: 621-625, 2006.
5. Eddahibi S, Humbert M, Fadel E, Raffestin B, Darmon M, Capron F, Simonneau G, Dartevelle P, Hamon M, Adnot S. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J Clin Invest 108: 1141-1150, 2001.
6. Exton JH. Regulation of phospholipase D. FEBS Lett 531: 58-61, 2002.
7. Fanburg BL, Lee SL. A new role for an old molecule: serotonin as a mitogen. Am J Physiol Lung Cell Mol Physiol 272: L795-L806, 1997.
8. Foster DA, Xu L. Phospholipase D in cell proliferation and cancer. Mol Cancer Res 1: 789-800, 2003.
9. Herve P, Drouet L, Dosquet C, Launay JM, Rain B, Simonneau G, Caen J, Duroux P. Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin. Am J Med 89: 117-120, 1990.
10. Herve P, Launay JM, Scrobohaci ML, Brenot F, Simonneau G, Petitpretz P, Poubeau P, Cerrina J, Duroux P, Drouet L. Increased plasma serotonin in primary pulmonary hypertension. Am J Med 99: 249-254, 1995.
11. Hinton JM, Adams D, Garland CJ. 5-hydroxytryptamine stimulation of phospholipase D activity in the rabbit isolated mesenteric artery. Br J Pharmacol 126: 1601-1608, 1999.
12. Johnson MS, Robertson DN, Holland PJ, Lutz EM, Mitchell R. Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF). Cell Signal 18: 1793-1800, 2006.
13. Khan NA, Hichami A. Ionotrophic 5-hydroxytryptamine type 3 receptor activates the protein kinase C-dependent phospholipase D pathway in human T-cells. Biochem J 344: 199-204, 1999.
14. Ktistakis NT, Delon C, Manifava M, Wood E, Ganley I, Sugars JM. Phospholipase D1 and potential targets of its hydrolysis product, phosphatidic acid. Biochem Soc Trans 31: 94-97, 2003.
15. Kurscheid-Reich D, Throckmorton DC, Rasmussen H. Serotonin activates phospholipase D in rat mesangial cells. Am J Physiol Renal Fluid Electrolyte Physiol 268: F997-F1003, 1995.
16. Lee SL, Wang WW, Finlay GA, Fanburg BL. Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion. Am J Physiol Lung Cell Mol Physiol 277: L282-L291, 1999.
17. Lee SL, Wang WW, Lanzillo JJ, Fanburg BL. Regulation of serotonin-induced DNA synthesis of bovine pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 266: L53-L60, 1994.
18. Liu Y, Fanburg BL. Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/ serinethreonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. Am J Respir Cell Mol Biol 34: 182-191, 2006.
19. Liu Y, Li M, Warburton RR, Hill NS, Fanburg BL. The 5-HT transporter transactivates the PDGFbeta receptor in pulmonary artery smooth muscle cells. Faseb J 21: 2725-2734, 2007.
20. Liu Y, Suzuki YJ, Day RM, Fanburg BL. Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res 95: 579-586, 2004.
21. Lopez I, Arnold RS, Lambeth JD. Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol Chem 273: 12846-12852, 1998.
22. Marcos E, Fadel E, Sanchez O, Humbert M, Dartevelle P, Simonneau G, Hamon M, Adnot S, Eddahibi S. Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circ Res 94: 1263-1270, 2004.
23. McGrew L, Chang MS, Sanders-Bush E. Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. Mol Pharmacol 62: 1339-1343, 2002.
24. Morris AJ. Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides. Biochem Soc Symp: 247-257, 2007.
25. Natarajan V, Garcia JG. Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium. J Lab Clin Med 121: 337-347, 1993.
26. Palomaki VA, Laitinen JT. The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections. Br J Pharmacol 147: 596-606, 2006.
27. Plevin NAKR, Wakelam MJ, Wadsworth R. Regulation by hypoxia of endothelin-1-stimulated phospholipase D activity in sheep pulmonary artery cultured smooth muscle cells (Abstract). Br J Pharmacol 112: 5, 1994.
28. Rizzo M, Romero G. Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade. Pharmacol Ther 94: 35-50, 2002.
29. Rizzo MA, Kraft CA, Watkins SC, Levitan ES, Romero G. Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascade. J Biol Chem 276: 34928-34933, 2001.
30. Ross R. The smooth muscle cell: II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 50: 172-186, 1971.
31. Rothman RB, Ayestas MA, Dersch CM, Baumann MH. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation 100: 869-875, 1999.
32. Salvador GA, Ilincheta de Boschero MG, Pasquare SJ, Giusto NM. Phosphatidic acid and diacylglycerol generation is regulated by insulin in cerebral cortex synaptosomes from adult and aged rats. J Neurosci Res 81: 244-252, 2005.
33. Walker SJ, Brown HA. Measurement of G protein-coupled receptor-stimulated phospholipase D activity in intact cells. Methods Mol Biol 237: 89-97, 2004.
34. Wang L, Cummings R, Zhao Y, Kazlauskas A, Sham JK, Morris A, Georas S, Brindley DN, Natarajan V. Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem 278: 39931-39940, 2003.