Large Eddy simulation and Reynolds-Averaged Navier-Stokes modeling of flow in a realistic pharyngeal airway model: An investigation of obstructive sleep apnea

Journal of Biomechanics

Volumn 41, Issue 10, 2008, Pages 2279-2288

  Mihaescu, Mihai ^a   Murugappan, Shanmugam ^b   Kalra, Maninder ^c   Khosla, Sid ^b   Gutmark, Ephraim ^a,b  

^a University of Cincinnati   (United States)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

LES; Obstructive sleep apnea; Pharyngeal airway; RANS

Indexed keywords

COMPUTATIONAL FLUID DYNAMICS; EDDY CURRENTS; FLOW CONTROL; FLOW SEPARATION; LARGE EDDY SIMULATION; MAGNETIC RESONANCE; NAVIER STOKES EQUATIONS; RESPIRATORY SYSTEM; SLEEP RESEARCH; TURBULENCE MODELS;

COMPUTATIONAL FLUID DYNAMICS TECHNIQUE; OBSTRUCTIVE SLEEP APNEA; PHARYNGEAL AIRWAY; RANS; REYNOLDS AVERAGED NAVIER-STOKES MODELS; REYNOLDS-AVERAGED NAVIER-STOKES; STATIC PRESSURE DISTRIBUTIONS; TWO-EQUATION TURBULENCE MODELS;

SHEAR FLOW;

AIRFLOW; AIRWAY DYNAMICS; ANISOTROPY; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; FLOW MEASUREMENT; IMAGE RECONSTRUCTION; LARGE EDDY SIMULATION; MATHEMATICAL MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHARYNX; PRIORITY JOURNAL; REYNOLDS AVERAGED NAVIER STOKES MODEL; SIMULATION; SLEEP APNEA SYNDROME; TURBULENT FLOW; AUDIOVISUAL EQUIPMENT; BIOMECHANICS; BREATHING MECHANICS; COMPUTER PROGRAM; COMPUTER SIMULATION; HISTOLOGY; HUMAN; MECHANICAL STRESS; METHODOLOGY; NONLINEAR SYSTEM; PATHOPHYSIOLOGY; PRESSURE; THEORETICAL MODEL; TRACHEA;

ANISOTROPY; BIOMECHANICS; COMPUTER SIMULATION; HUMANS; MAGNETIC RESONANCE IMAGING; MODELS, ANATOMIC; MODELS, THEORETICAL; NONLINEAR DYNAMICS; PHARYNX; PRESSURE; RESPIRATORY MECHANICS; SLEEP APNEA, OBSTRUCTIVE; SOFTWARE; STRESS, MECHANICAL; TRACHEA;

EID: 52649099946     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2008.04.013     Document Type: Article

References (32)

1. Arens, R., McDonough, J.M., Corbin, A.M., Rubin, N.K., Carroll, M.E., Pack, A.I., Liu, J., Udupa, J.K., 2003. Upper airway size analysis by magnetic resonance imaging of children with obstructive sleep apnea syndrome. American Journal of Respiratory and Critical Care Medicine 167, 65-70.
2. Boudier, G., Gicquel, L.Y.M., Poinsot, T., Bissières, D., Bérat, C., 2007. Comparison of LES, RANS and experiments in an aeronautical gas turbine combustion chamber. Proceedings of the Combustion Institute 31, 3075-3082.
3. Breuer, M., Jaffrézic, B., Peller, N., Manhart, M., Fröhlich, J., Hinterberger, C., Rodi, W., Deng, G., Chikhaoui, O., uSarić, S., Jakirlić, S., 2006. A Comparative Study of the Turbulent Flow over a Periodic Arrangement of Smoothly Contoured Hills. Direct and Large Eddy Simulation, vol. VI. Springer, Netherlands, pp. 635-642.
4. Collins, T.P., Tabor, G.R., Young, P.G., 2007. A computational fluid dynamics study of inspiratory flow in orotracheal geometries. Medical and Biological Engineering and Computing 45, 829-836.
5. De Backer, W., 2006. Obstructive sleep apnea - hypopnea syndrome. Progress in Respiratory Research Basel Karger 35, 90-96.
6. Horner, R.L., Shea, S.A., Mcivor, J., Guz, A., 1989. Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnea. Quarterly Journal of Medicine 72 (268), 719-735.
7. Hudgel, D.W., 1986. Variable site of airway narrowing among obstructive sleep apnea patients. Journal of Applied Physiology 61, 1403-1409.
8. Jeong, S.-J., Kim, W.-S., Sung, S.-J., 2007. Numerical investigation on the flow characteristics and aerodynamic force of the upper airway of patient with obstructive sleep apnea using computational fluid dynamics. Medical Engineering & Physics 29, 637-651.
9. Jin, H.H., Fan, J.R., Zeng, M.J., Cen, K.F., 2007. Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. Journal of Aerosol Science 38, 257-268.
10. Kleinstreuer, C., Zhang, Z., 2003. Laminar-to-turbulent fluid-particle flows in a human airway model. International Journal of Multiphase Flow 29, 271-289.
11. Lilly, D.K., 1966. On the application of the eddy viscosity concept in the inertial subrange of turbulence. NCAR Manuscript 123.
12. Luo, X.Y., Hinton, J.S., Liew, T.T., Tan, K.K., 2004. LES modeling of flow in a simple airway model. Medical Engineering & Physics 26, 403-413.
13. Mahesh, K., Constantinescu, S.G., Moin, P., 2004. A numerical method for large-Eddy simulation in complex geometries. Journal of Computational Physics 197, 215-240.
14. Malhotra, A., White, D.P., 2002. Obstructive sleep apnea. Lancet 360 (9328), 237-245.
15. Matida, E.A., Finlay, W.H., Breuer, M., Lange, C.F., 2006. Improving prediction of aerosol deposition in an idealized mouth using large-eddy simulation. Journal of Aerosol Medicine 19 (3), 290-300.
16. Medic, G., Daeninck, G., Templeton, J.A., Kalitzin, G., 2005. A framework for near-wall RANS/LES coupling. Center for Turbulence Research. Annual Research Briefs, 2005, pp. 169-182.
17. Mongia, H.C., 2008. Recent progress in comprehensive modeling of gas turbine combustion. AIAA Paper, AIAA 2008-1445.
18. Morrell, M.J., Arabi, Y., Zahn, B., Badr, M.S., 1998. Progressive retropalatal narrowing preceding obstructive apnea. American Journal of Respiratory and Critical Care Medicine 158, 1974-1981.
19. Nithiarasu, P., Liu, C.-B., Massarotti, N., 2007. Laminar and turbulent flow calculations through a model human upper airway using unstructured meshes. Communications in Numerical Methods in Engineering 23, 1057-1069.
20. Pedley, T.J., 1977. Pulmonary fluid dynamics. Annual Review of Fluid Mechanics 9, 229-274.
21. Pope, S.B., 2000. Turbulent Flows. Cambridge University Press, Cambridge.
22. Schwab, R.J., Gupta, K.B., Gefter, W.B., Metzger, L.J., Hoffman, E.A., Pack, A.I., 1995. Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing: significance of the lateral pharyngeal walls. American Journal of Respiratory and Critical Care Medicine 152, 1673-1689.
23. Sung, S.-J., Jeong, S.-J., Yu, Y.-S., Hwang, C.-J., Pae, E.-K., 2006. Customized three-dimensional computational fluid dynamics simulation of the upper airway of obstructive sleep apnea. Angle Orthodontist 76 (5), 791-799.
24. Szasz, R.Z., Revstedt, J., Fuchs, L., 2004. Comparison of Some SGS Models for Turbulent Fluxes of Momentum and a Passive Scalar in Swirling Co-Annular Jets, Direct and Large Eddy Simulation, vol. V. Kluwer Academic Publishers, pp. 545-554.
25. Temmerman, L., Leschziner, M.A., Mellen, C.P., Fröhlich, J., 2003. Investigation of wall-function approximations and subgrid-scale models in large eddy simulation of separated flow in a channel with streamwise periodic constrictions. International Journal of Heat and Fluid Flow 24, 157-180.
26. Tokyay, T.E., Constantinescu, S.G., 2006. Validation of a large-Eddy simulation model to simulate flow in pumps intakes of realistic geometries. Journal of Hydraulic Engineering 132 (12), 1303-1315.
27. Vandoormaal, J.P., Raithby, G.D., 1984. Enhancements of the simple method for predicting incompressible fluid flows. Numerical Heat Transfer 7, 147-163.
28. Varghese, S.S., Frankel, S.H., Fischer, P.F., 2008. Modeling transition to turbulence in eccentric stenotic flows. Journal of Biomechanical Engineering 130 (1), 014503.
29. Vos, W., De Backer, J., Devolder, A., Vanderveken, O., Verhulst, S., Salgado, R., Germonpre, P., Partoens, B., Wuyts, F., Parizel, P., De Backer, W., 2007. Correlation between severity of sleep apnea and upper airway morphology based on advanced anatomical and functional imaging. Journal of Biomechanics 40 (10), 2207-2213.
30. Wilcox, D.C., 1993. Turbulence Modeling for CFD. DCW Industries, La Canada, CA.
31. Xu, C., Sin, S., McDonough, J.M., Udupa, J.K., Guez, A., Arens, R., Wootton, D.M., 2006. Computational fluid dynamics modeling of the upper airway of children with obstructive sleep apnea syndrome in steady flow. Journal of Biomechanics 39, 2043-2054.
32. Zhang, Z., Kleinstreuer, C., Kim, C.S., 2002. Micro-particle transport and deposition in a human oral airway model. Aerosol Science 33, 1635-1652.