Computational fluid dynamics modeling of the upper airway of children with obstructive sleep apnea syndrome in steady flow

Journal of Biomechanics

Volumn 39, Issue 11, 2006, Pages 2043-2054

  Xu, Chun ^a   Sin, SangHun ^b,c   McDonough, Joseph M ^c   Udupa, Jayaram K ^d   Guez, Allon ^a   Arens, Raanan ^c   Wootton, David M ^a  

^a Drexel University   (United States)

^b DREXEL UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Flow resistance; Human; Magnetic resonance imaging (MRI); Pharynx; Pressure

Indexed keywords

AIRWAY GEOMETRY; OBSTRUCTIVE SLEEP APNEA SYNDROME (OSAS); PHARYNX PRESSURE;

BOUNDARY CONDITIONS; MAGNETIC RESONANCE IMAGING; NAVIER STOKES EQUATIONS; PRESSURE DISTRIBUTION; REYNOLDS NUMBER; STEADY FLOW;

COMPUTATIONAL FLUID DYNAMICS;

ADENOID; AIRWAY PRESSURE; ARTICLE; ATMOSPHERIC PRESSURE; BREATHING; CASE REPORT; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; CORRELATION ANALYSIS; EXHALATION; FEMALE; GEOMETRY; HUMAN; IN VITRO STUDY; INHALATION; MALE; MATHEMATICAL MODEL; NASOPHARYNX; NOSE AIRWAY RESISTANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; OROPHARYNX; PEAK EXPIRATORY FLOW; PHARYNX; PRESCHOOL CHILD; PRIORITY JOURNAL; SIMULATION; SLEEP APNEA SYNDROME; TONSIL; UPPER RESPIRATORY TRACT;

BIOMECHANICS; CHILD; CHILD, PRESCHOOL; COMPUTER SIMULATION; FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; PRESSURE; RESPIRATORY SYSTEM; RHEOLOGY; SLEEP APNEA, OBSTRUCTIVE;

EID: 33745868029     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2005.06.021     Document Type: Article

References (36)

1. Aittokallio T., Gyllenberg M., and Polo O. Adjustment of the human respiratory system to increased upper airway resistance during sleep. A model of a snorer's upper airway. Bulletin of Mathematical Biology 64 (2002) 3-28
2. Ali N.J., Pitson D.J., and Stradling J.R. Snoring, sleep disturbance, and behaviour in 4-5 year olds. Archives of Disease in Childhood 68 (1993) 360-366
3. Allen G.M., Shortall B.P., Gemci T., Corcoran T.E., and Chigier N.A. Computational simulations of airflow in an in vitro model of the pediatric upper airways. Journal of Biomechanical Engineering 126 (2004) 604-613
4. Arens R., McDonough J.M., Costarino A.T., Tayag-Kier C.E., Mahboubi S., Schwab R.J., and Pack A.I. Magnetic resonance imaging of the upper airway structure in children with obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine 164 (2001) 698-703
5. Arens R., McDonough J.M., Corbin A.M., Hernandez M.E., Maislin G., and Schwab R.J. Linear diensions of the upper airway structure during development. American Journal of Respiratory and Critical Care Medicine 165 (2002) 117-122
6. Arens R., McDonough J.M., Corbin A.M., Rubin N.K., Carroll M.E., Pack A.I., Liu J., and Udupa J.K. Upper airway size analysis by magnetic resonance imaging of children with obstructive sleep apnea syndrome. American Journal of Respiratory and Critical Care Medicine 167 (2003) 65-70
7. Arens R., Sin S., McDonough J.M., Palmer J.M., Dominguez T., Meyer H., Wootton D.M., and Pack A.I. Changes in upper airway size during tidal breathing in children with obstructive sleep apnea syndrome. American Journal of Respiratory and Critical Care Medicine 171 (2005) 1298-1304
8. Bathe M., and Kamm R.D. A fluid-structure interaction finite element analysis of pulsatile blood flow through a compliant stenotic artery. Journal of Biomechanical Engineering 121 (1999) 361-369
9. Bockholt U., Mlynski G., Muller W., and Voss G. Rhinosurgical therapy planning via endonasal airflow simulation. Computer Aided Surgery 5 (2000) 175-179
10. Brouilette R., Hanson D., David R., Klemka L., Szatkowski A., Fernbach S., and Hunt C. A diagnostic approach to suspected obstructive sleep apnea in children. Journal of Pediatrics 105 (1984) 10-14
11. Elad D., Liebenthal R., Wenig B.L., and Einav S. Analysis of air flow patterns in the human nose. Medical and Biological Engineering and Computing 31 (1993) 585-592
12. Hahn I., Scherer P.W., and Mozell M.M. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. Journal of Applied Physiology 75 (1993) 2273-2287
13. Huang Y., Malhotra A., and White D.P. Computational simulation of human upper airway collapse using a pressure/state-dependent model of genioglossal muscle contraction under liminar flow conditions. J. Appl. Physiol (2005)
14. Isono S., Morrison D.L., Launois S.H., Feroah T.R., Whitelaw W.A., and Remmers J.E. Static mechanics of the velopharynx of patients with obstructive sleep apnea. Journal of Applied Physiology 75 (1993) 148-154
15. Isono S., Shimada A., Utsugi M., Konno A., and Nishino T. Comparison of static mechanical properties of the passive pharynx between normal children and children with sleep-disordered breathing. American Journal of Respiratory and Critical Care Medicine 157 (1998) 1204-1212
16. Keyhani K., Scherer P.W., and Mozell M.M. Numerical simulation of airflow in the human nasal cavity. Journal of Biomechanical Engineering 117 (1995) 429-441
17. Ku D.N., Zeigler M.N., and Downing J.M. One-dimensional steady inviscid flow through a stenotic collapsible tube. Journal of Biomechanical Engineering 112 (1990) 444-450
18. Leiter J.C. Analysis of pharyngeal resistance and genioglossal EMG activity using a model of orifice flow. Journal of Applied Physiology 73 (1992) 576-583
19. Liu J., Udupa J.K., Odhner D., McDonough J.M., and Arens R. System for upper airway segmentation and measurement with MR imaging and fuzzy connectedness. Academic Radiology 10 (2003) 13-24
20. Malhotra A., Huang Y., Fogel R.B., Pillar G., Edwards J.K., Kikinis R., Loring S.H., and White D.P. The male predisposition to pharyngeal collapse: importance of airway length. American Journal of Respiratory and Critical Care Medicine 166 (2002) 1388-1395
21. Marcus C.L., McColley S.A., Carroll J.L., Loughlin G.M., Smith P.L., and Schwartz A.R. Upper airway collapsibility in children with obstructive sleep apnea syndrome. Journal of Applied Physiology 77 (1994) 918-924
22. Marcus C.L., Katz E.S., Lutz J., Black C.A., Galster P., and Carson K.A. Upper airway dynamic responses in children with the obstructive sleep apnea syndrome. Pediatric Research (2004)
23. Martonen T.B., Quan L., Zhang Z., and Musante C.J. Flow simulation in the human upper respiratory tract. Cell Biochemistry and Biophysics 37 (2002) 27-36
24. Morrell M.J., Arabi Y., Zahn B., and Badr M.S. Progressive retropalatal narrowing preceding obstructive apnea. American Journal of Respiratory and Critical Care Medicine 158 (1998) 1974-1981
25. Munson B.R., Young D.F., and Okiishi T.H. Fundamentals of Fluid Mechanics (2002), Wiley, New York (840pp)
26. Redline S., Tishler P.V., Schluchter M., Aylor J., Clark K., and Graham G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. American Journal of Respiratory and Critical Care Medicine 159 (1999) 1527-1532
27. Rizzi M., Onorato J., Andreoli A., Colombo S., Pecis M., Marchisio P., Morelli M., Prinicipi N., Esposito S., and Sergi M. Nasal resistances are useful in identifying children with severe obstructive sleep apnea before polysomnography. International Journal of Pediatric Otorhinolaryngology 65 (2002) 7-13
28. Schwab R.J., Gefter W.B., Hoffman E.A., Gupta K.B., and Pack A.I. Dynamic upper airway imaging during awake respiration in normal subjects and patients with sleep disordered breathing. American Review of Respiratory Disease 148 (1993) 1385-1400
29. Schwab R.J., Gefter W.B., Pack A.I., and Hoffman E.A. Dynamic imaging of the upper airway during respiration in normal subjects. Journal of Applied Physiology 74 (1993) 1504-1514
30. Shome B., Wang L.P., Santare M.H., Prasad A.K., Szeri A.Z., and Roberts D. Modeling of airflow in the pharynx with application to sleep apnea. Journal of Biomechanical Engineering 120 (1998) 416-422
31. Stocks J., Sly P.D., Tepper R.S., and Morgan W.J. Infant Respiratory Function Testing (1996), Wiley-Liss, Inc., New York
32. Tang D., Yang C., Kobayashi S., and Ku D.N. Steady flow and wall compression in stenotic arteries: a three-dimensional thick-wall model with fluid-wall interactions. Journal of Biomechanical Engineering 123 (2001) 548-557
33. Udupa J.K., Odhner D., Samarasekera S., Goncalves R.J., Iyer K., Venugopal K., and Furule S. 3DVIEWNIX: an open, transportable, multidimensional, multimodality, multiparametric imaging software system. SPIE Proceedings 2164 (1994) 58-73
34. Young D.F. Fluid mechanics of arterial stenoses. Journal of Biomechanical Engineering 101 (1979) 157-175
35. Young D.F., and Tsai F.Y. Flow characteristics in models of arterial stenoses-I. Steady flow. Journal Biomechanics 6 (1973) 395-410
36. Zapletal A., and Chalupova J. Nasal airflow and resistance measured by active anterior rhinomanometry in healthy children and adolescents. Pediatric Pulmonology 33 (2002) 174-180