Granulosa cell tumor of the ovary: Tumor review

Integrative Cancer Therapies

Volumn 7, Issue 3, 2008, Pages 204-215

  Koukourakis, Georgios V ^a,e   Kouloulias, Vasilios E ^a   Koukourakis, Michael J ^b   Zacharias, Georgios A ^a   Papadimitriou, Christos ^c   Mystakidou, Kyriaki ^a   Pistevou Gompaki, Kyriaki ^d   Kouvaris, John ^a   Gouliamos, Athanasios ^a  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d AHEPA UNIVERSITY HOSPITAL   (Greece)

^e University Hospital of Athens   (Greece)

Author keywords

Etiology; Granulosa cell tumor; Prognosis; Treatment; Tumor markers

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BLEOMYCIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CARBOPLATIN; CISPLATIN; CLOMIFENE; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ESTRADIOL; ETOPOSIDE; FLUOROURACIL; FOLLITROPIN; GEMCITABINE; GESTAGEN; GONADOTROPIN DERIVATIVE; GOSERELIN; INHIBIN; LEUPRORELIN; MEDROXYPROGESTERONE; OXALIPLATIN; PACLITAXEL; PROGESTERONE RECEPTOR; TAMOXIFEN; VINBLASTINE; VINCRISTINE;

ABDOMINAL PAIN; CANCER INCIDENCE; CANCER RELAPSE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; DISEASE ASSOCIATION; DRUG EFFICACY; ECHOGRAPHY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; GENE MUTATION; GRANULOSA CELL TUMOR; HEMOPERITONEUM; HORMONAL THERAPY; HORMONE RELEASE; HUMAN; HYSTERECTOMY; ONCOGENE; OVARY CANCER; OVARY HYPERSTIMULATION; PNEUMONIA; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE; REVIEW; RISK FACTOR; SALPINGOOOPHORECTOMY; SEPSIS; TREATMENT RESPONSE; TUMOR RECURRENCE; TUMOR VOLUME; VAGINA BLEEDING;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; GRANULOSA CELL TUMOR; HUMANS; NEOPLASM STAGING; OVARIAN NEOPLASMS; PROGNOSIS; RADIOTHERAPY, ADJUVANT; TUMOR MARKERS, BIOLOGICAL;

EID: 52649097039     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735408322845     Document Type: Review

References (99)

1. Evans AT III, Gaffey TA, Malkasian GD Jr, Annegers JF Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol. 1980 ; 55: 231-238.
2. Fox H., Agrawal K., Langley FA A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer. 1975: 35: 231-241.
3. Schumer ST, Cannistra SA Granulosa cell tumor of the ovary. J Clin Oncol. 2003 ; 21: 1180-1189.
4. Unkila-Kallio L., Tiitinen A., Wahlstrom T., Lehtovirta P., Leminen A. Reproductive features in women developing ovarian granulosa cell tumour at a fertile age. Hum Reprod. 2000 ; 15: 589-593.
5. Young RH, Dickersin DR, Scully RE Juvenile granulosa cell tumor of the ovary: a clinicopathological analysis of 125 cases. Am J Surg Pathol. 1984 ; 8: 575-596.
6. Scully RE Juvenile granulosa cell tumor. Pediatr Pathol. 1988 ; 8: 423-427.
7. Vassal G., Flamant F., Caillaud JM, Demeocq F., Nihoul-Fekete C., Lemerle J. Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases, J Clin Oncol. 1988 ; 6: 990-995.
8. Biscotti CV, Hart WR Juvenile granulosa cell tumors of the ovary. Arch Pathol Lab Med. 1989 ; 113: 40-46.
9. Cronje HS, Niemand I., Bam RH, JWoodruff JD Granulosa and theca cell tumors in children: a report of 17 cases and literature review. Obstet Gynecol Surv. 1998 ; 53: 240-247.
10. Bjorkholm E., Silfversward C. Prognostic factors in granulosa-cell tumors. Gynecol Oncol. 1981 ; 11: 261-274.
11. Ohel G., Kaneti H., Schenker JG Granulosa cell tumors in Israel: a study of 172 cases. Gynecol Oncol. 1983 ; 15: 278-286.
12. Malmstrom H., Hogberg T., Risberg B., Simonsen E. Granulosa cell tumors of the ovary: prognostic factors and outcome, Gynecol Oncol. 1994 ; 52: 50-55.
13. Savage P., Constenla D., Fisher C., et al. Granulosa cell tumours of the ovary: demographics, survival and the management of advanced disease. Clin Oncol (R Coll Radiol). 1998 ; 10: 242-245.
14. Miller BE, Barron BA, Wan JY, Delmore DE, Silva EG, Gershenson DM Prognostic factors in adult granulosa cell tumor of the ovary. Cancer. 1997 ; 79: 1951-1955.
15. Stenwig JT, Hazekamp JT, Beecham JB Granulosa cell tumors of the ovary: a clinicopathological study of 118 cases with long-term follow-up. Gynecol Oncol. 1979 ; 7: 136-152.
16. Pankratz E., Boyes DA, White GW, Galliford BW, Fairey RN, Benedet LN Granulosa cell tumors: a clinical review of 61 cases. Obstet Gynecol. 1978 ; 52: 718-723.
17. Bennington JL, Ferguson BR, Haber SL Incidence and relative frequency of benign and malignant ovarian neoplasms. Obstet Gynecol. 1968 ; 32: 627-632.
18. Nakashima M., Young RH, Scully RE Androgenic granulosa cell tumors of the ovary: a clinicopathologic analysis of 17 cases and review of the literature. Arch Pathol Lab Med. 1984 ; 108: 786-791.
19. Willemsen W., Kruitwagen R., Bastiaans B., Hanselaar T., Rolland R. Ovarian stimulation and granulosa-cell tumour, Lancet. 1993 ; 341: 986-988.
20. Segal R., DePetrillo AD, Thomas G. Clinical review of adult granulosa cell tumors of the ovary. Gynecol Oncol. 1995 ; 56: 338-344.
21. Schwartz PE, Smith JP Treatment of ovarian stromal tumors. Am J Obstet Gynecol. 1976 ; 125: 402-411.
22. Young RH, Clement PB, Scully RE: The ovary. In: Sternberg SS, Mills SE, eds. Surgical Pathology of the Female Reproductive System and Peritoneum. New York, NY: Raven Press; 1991: 169-248.
23. Gusberg SB, Kardon P. Proliferative endometrial response to theca-granulosa cell tumors. Am J Obstet Gynecol. 1971 ; 111: 633-643.
24. Lack EE, Perez-Atayde AR, Murthy AS, Goldstein DP, Crigler JF Jr, Vawter GF Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases. Cancer. 1981 ; 48: 1846-1854.
25. Roth LM, Nicholas TR, Ehrlich CE Juvenile granulosa cell tumor: a clinicopathologic study of three cases with ultrastructural observations. Cancer. 1979 ; 44: 2194-2205.
26. Pysher TJ, Hitch DC, Krous HF Bilateral juvenile granulosa cell tumors in a 4-month-old dysmorphic infant: a clinical, histologic, and ultrastructural study. Am J Surg Pathol. 1981 ; 5: 789-794.
27. Tamimi HK, Bolen JW Enchondromatosis (Ollier's disease) and ovarian juvenile granulosa cell tumor. Cancer. 1984 ; 53: 1605-1608.
28. Velasco-Oses A., Alonso-Alvaro A., Blanco-Pozo A., Nogales FF Jr. Ollier's disease associated with ovarian juvenile granulosa cell tumor. Cancer. 1988 ; 62: 222-225.
29. Lewis RJ, Ketcham AS Maffucci's syndrome: functional and neoplastic significance: case report and review of the literature. J Bone Joint Surg Am. 1973 ; 55: 1465-1479.
30. Norris HJ, Taylor HB Prognosis of granulosa-theca tumors of the ovary. Cancer. 21: 255-263.
31. Giuntoli RL, Celebre JA, Wu CH, Wheeler JE, Mikuta JJ Androgenic function of a granulosa cell tumor. Obstet Gynecol. 1976 ; 47: 77-79.
32. Choi CH, Pritchard JR Large cystic granulosa cell tumor: case report. Am J Obstet Gynecol. 1990 ; 163: 74-76.
33. Diddle AW Granulosa- and theca-cell ovarian tumors: prognosis. Cancer. 1952 ; 5: 215-228.
34. Hines JF, Khalifa MA, Moore JL, Fine KP, Lage JM, Barnes WA Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol. 1996 ; 60: 484-488.
35. Ko SF, Wan YL, Ng SH, et al. Adult ovarian granulosa cell tumors: spectrum of sonographic and CT findings with pathologic correlation. AJR Am J Roentgenol. 1999 ; 172: 1227-1233.
36. Kim SH, Kim SH Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. J Comput Assist Tomogr. 2002 ; 26: 756-761.
37. Morikawa K., Hatabu H., Togashi K., Kataoka ML, Mori T., Konishi J. Granulosa cell tumor of the ovary: MR findings. J Comput Assist Tomogr. 1997 ; 21: 1001-1004.
38. Outwater EK, Wagner BJ, Mannion C., McLarney JK, Kim B. Sex cord-stromal and steroid cell tumors of the ovary. Radiographics. 1998 ; 18: 1523-1546.
39. Kaye SB, Davies E. Cyclophosphamide, adriamycin, and cis-platinum for the treatment of advanced granulosa cell tumor, using serum estradiol as a tumor marker. Gynecol Oncol. 1986 ; 24: 261-264.
40. Lappohn RE, Burger HG, Bouma J., Bangah M., Krans M., de Bruijn HW Inhibin as a marker for granulosa-cell tumors. N Engl J Med. 1989 ; 321: 790-793.
41. Rey RA, Lhomme C., Marcillac I., et al. Antimullerian hormone as a serum marker of granulosa cell tumors of the ovary: comparative study with serum alpha-inhibin and estradiol. Am J Obstet Gynecol. 1996 ; 74: 958-965.
42. Burger HG What do inhibin measurements tell a clinician today ? Ann Med. 1992 ; 24: 419-421.
43. Burger HG Evidence for a negative feedback role of inhibin in follicle stimulating hormone regulation in women. Hum Reprod. 1993 ; 8 (suppl 2). 129-132.
44. Gurusinghe CJ, Healy DL, Jobling T., Mamers P., Burger HG Inhibin and activin are demonstrable by immunohistochemistry in ovarian tumor tissue. Gynecol Oncol. 1995 ; 57: 27-32.
45. Petraglia F., Luisi S., Pautier P., et al. Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumors. J Clin Endocrinol Metab. 1998 ; 83: 1029-1032.
46. Robertson DM, Cahir N., Burger HG, Mamers P., Groome N. Inhibin forms in serum from postmenopausal women with ovarian cancers. Clin Endocrinol (Oxf). 1999 ; 50: 381-386.
47. Yamashita K., Yamoto M., Shikone T., et al. Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. Am J Obstet Gynecol. 1997 ; 177: 1450-1457.
48. Healy DL, Burger HG, Mamers P., et al. Elevated serum inhibin concentrations in postmenopausal women with ovarian tumors. N Engl J Med. 1993 ; 329: 1539-1542.
49. Boggess JF, Soules MR, Goff BA, Greer BE, Cain JM, Tamimi HK Serum inhibin and disease status in women with ovarian granulosa cell tumors. Gynecol Oncol. 1997 ; 64: 64-69.
50. Rodgers KE, Marks JF, Ellefson DD, et al. Follicle regulatory protein: a novel marker for granulosa cell cancer patients. Gynecol Oncol. 1990 ; 37: 381-387.
51. Lauszus FF, Petersen AC, Greisen J., Jakobsen A. Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. Gynecol Oncol. 2001 ; 81: 456-460.
52. Bjorkholm E., Pettersson F. Granulosa-cell and theca-cell tumors: the clinical picture and long-term outcome for the Radiumhemmet series. Acta Obstet Gynecol Scand. 1980 ; 59: 361-365.
53. Fox H. Pathologic prognostic factors in early stage adult-type granulosa cell tumors of the ovary. Int J Gynecol Cancer. 2003 ; 13: 1-4.
54. Fontanelli R., Stefanon B., Raspagliesi F., et al. Adult granulosa cell tumor of the ovary: a clinico pathologic study of 35 cases. Tumori. 1998 ; 84: 60-64.
55. Fujimoto T., Sakuragi N., Okuyama K., et al. Histopathological prognostic factors of adult granulosa cell tumors of the ovary. Acta Obstet Gynecol Scand. 2001 ; 80: 1069-1074.
56. Sommers SC, Gates O., Goodof II Late recurrence of granulosa cell tumors: report of two cases. Obstet Gynecol. 1955 ; 6: 395-398.
57. Kietlinska Z., Pietrzak K., Drabik M. The management of granulosa-cell tumors of the ovary based on long-term follow up. Eur J Gynaecol Oncol. 1993 ; 14 (suppl): 118-127.
58. Miller BE, Barron BA, Dockter ME, Delmore JE, Silva EG, Gershenson DM Parameters of differentiation and proliferation in adult granulosa cell tumors of the ovary. Cancer Detect Prev. 2001 ; 25: 48-54.
59. Schneider DT, Calaminus G., Wessalowski R., et al. Ovarian sex cord-stromal tumors in children and adolescents. J Clin Oncol. 2003 ; 21: 2357-2363.
60. Vesco KK, Carney ME Granulosa cell tumor of the ovary: extensive late recurrence after initial occult microscopic disease. Obstet Gynecol. 2002 ; 99 (5, pt 2). 888-891.
61. Juric G., Zarkovic N., Nola M., Tillian M., Jukic S. The value of cell proliferation and angiogenesis in the prognostic assessment of ovarian granulosa cell tumors. Tumori. 2001 ; 87: 47-53.
62. King LA, Okagaki T., Gallup DG, Twiggs LB, Messing MJ, Carson LF Mitotic count, nuclear atypia, and immunohistochemical determination of Ki-67, c-myc, p21-ras, c-erbB2, and p53 expression in granulosa cell tumors of the ovary: mitotic count and Ki-67 are indicators of poor prognosis. Gynecol Oncol. 1996 ; 61: 227-232.
63. Wabersich J., Fracas M., Mazzer S., Marchetti M., Altavilla G. The value of the prognostic factors in ovarian granulosa cell tumors. Eur J Gynaecol Oncol. 1998 ; 19: 69-72.
64. Hitchcock CL, Norris HJ, Khalifa MA, Wargotz ES Flow cytometric analysis of granulosa tumors. Cancer. 1989 ; 64: 2127-2132.
65. Suh KS, Silverberg SG, Rhame JG, Wilkinson DS Granulosa cell tumor of the ovary: histopathologic and flow cytometric analysis with clinical correlation. Arch Pathol Lab Med. 1990 ; 114: 496-501.
66. Evans MP, Webb MJ, Gaffey TA, Katzmann JA, Suman VJ, Hu TC DNA ploidy of ovarian granulosa cell tumors: lack of correlation between DNA index or proliferative index and outcome in 40 patients. Cancer. 1995 ; 75: 2295-2298.
67. Klemi PJ, Joensuu H., Salmi T. Prognostic value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary. Cancer. 1990 ; 65: 1189-1193.
68. Haba R., Miki H., Kobayashi S., Ohmori M. Combined analysis of flow cytometry and morphometry of ovarian granulosa cell tumor. Cancer. 1993 ; 72: 3258-3262.
69. Roush GR, el- Naggar AK, Abdul-Karim FW Granulosa cell tumor of ovary: a clinicopathologic and flow cytometric DNA analysis. Gynecol Oncol. 1995 ; 56: 430-434.
70. Ala-Fossi SL, Maenpaa J., Aine R., Koivisto P., Koivisto AM, Punnonen R. Prognostic significance of p53 expression in ovarian granulosa cell tumors. Gynecol Oncol. 1997 ; 66: 475-479.
71. Gebhart JB, Roche PC, Keeney GL, Lesnick TG, Podratz KC Assessment of inhibin and p53 in granulosa cell tumors of the ovary. Gynecol Oncol. 2000 ; 77: 232-236.
72. Horny HP, Marx L., Krober S., Luttges J., Kaiserling E., Dietl J. Granulosa cell tumor of the ovary: immunohistochemical evidence of low proliferative activity and virtual absence of mutation of the p53 tumor-suppressor gene. Gynecol Obstet Invest. 1999 ; 47: 133-138.
73. Costa MJ, Walls J., Ames P., Roth LM Transformation in recurrent ovarian granulosa cell tumors: Ki67 (MIB-1) and p53 immunohistochemistry demonstrates a possible molecular basis for the poor histopathologic prediction of clinical behavior. Hum Pathol. 1996 ; 27: 274-281.
74. Margolin KA, Pak HY, Esensten ML, Doroshow JH Hepatic metastasis in granulosa cell tumor of the ovary. Cancer. 1985 ; 56: 691-695.
75. Neville AJ, Gilchrist KW, Davis TE The chemotherapy of granulosa cell tumors of the ovary: experience of the Wisconsin Clinical Cancer Center. Med Pediatr Oncol. 1984 ; 12: 397-400.
76. Malkasian GD Jr, Webb MJ, Jorgensen EO Observations on chemotherapy of granulosa cell carcinomas and malignant ovarian teratomas. Obstet Gynecol. 1974 ; 44: 885-888.
77. Wolf JK, Mullen J., Eifel PJ, Burke TW, Levenback C., Gershenson DM Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. Gynecol Oncol. 1999 ; 73: 35-41.
78. Lee IW, Levin W., Chapman W., Goldberg RE, Murphy KJ, Milosevic M. Radiotherapy for the treatment of metastatic granulosa cell tumor in the mediastinum: a case report. Gynecol Oncol. 1999 ; 73: 455-460.
79. Barlow JJ, Piver MS, Chuang JT, Cortes EP, Onuma T., Holland JF Adriamycin and bleomycin, alone and in combination, in gynecologic cancers. Cancer. 1973 ; 32: 735-743.
80. Disaia P., Saltz A., Kagan AR, Rich W. A temporary response of recurrent granulosa cell tumor to adriamycin. Obstet Gynecol. 1978 ; 52: 355-358.
81. Jacobs AJ, Deppe G., Cohen CJ Combination chemotherapy of ovarian granulosa cell tumor with cis-platinum and doxorubicin. Gynecol Oncol. 1982 ; 14: 294-297.
82. Schulman P., Cheng E., Cvitkovic E., Golbey R. Spontaneous pneumothorax as a result of intensive cytotoxic chemotherapy. Chest. 1979 ; 75: 194-196.
83. Gershenson DM, Copeland LJ, Kavanagh JJ, Stringer CA, Saul PB, Wharton JT Treatment of metastatic stromal tumors of the ovary with cisplatin, doxorubicin, and cyclophosphamide. Obstet Gynecol. 1987 ; 70: 765-769.
84. Camlibel FT, Caputo TA Chemotherapy of granulosa cell tumors. Am J Obstet Gynecol. 1983 ; 145: 763-765.
85. Pectasides D., Alevizakos N., Athanassiou AE Cisplatin-containing regimen in advanced or recurrent granulosa cell tumours of the ovary. Ann Oncol. 1992 ; 3: 316-318.
86. Colombo N., Sessa C., Landoni F., Sartori E., Pecorelli S., Mangioni C. Cisplatin, vinblastine, and bleomycin combination chemotherapy in metastatic granulosa cell tumor of the ovary. Obstet Gynecol. 1986 ; 67: 265-268.
87. Zambetti M., Escobedo A., Pilotti S., De Palo G. cis-Platinum/ vinblastine/bleomycin combination chemotherapy in advanced or recurrent granulosa cell tumors of the ovary. Gynecol Oncol. 1990 ; 36: 317-320.
88. Pecorelli S., Wagener P., Bonazzi G., et al. Cisplatin (P), vinblastine (V), and bleomycin (B) combination chemotherapy in recurrent or advanced granulosa cell tumor of the ovary (GCTO): an EORTC Gynecologic Cancer Cooperative Group study. Proc Am Soc Clin Oncol. 1988 ; 7: 147. Abstract 567.
89. Gershenson DM, Morris M., Burke TW, Levenback C., Matthews CM, Wharton JT Treatment of poor-prognosis sex cord-stromal tumors of the ovary with the combination of bleomycin, etoposide, and cisplatin. Obstet Gynecol. 1996 ; 87: 527-531.
90. Homesley HD, Bundy BN, Hurteau JA, Roth LM Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: a Gynecologic Oncology Group study. Gynecol Oncol. 1999 ; 72: 131-137.
91. Tresukosol D., Kudelka AP, Edwards CL, Charnsangavej C., Narboni N., Kavanagh JJ Recurrent ovarian granulosa cell tumor: a case report of a dramatic response to Taxol. Int J Gynecol Oncol. 1995 ; 5: 156-159.
92. Brown J., Shvartsman HS, Deavers MT, et al. The activity of taxanes compared with bleomycin, etoposide and cisplatin in the treatment of sex cord-stromal ovarian tumors. Gynecol Oncol. 2003 ; 97: 489-496.
93. Simmons RL, Sciarra JJ Treatment of late recurrent granulosa cell tumors of the ovary. Surg Gynecol Obstet. 1967 ; 124: 65-70.
94. Schwartz PE, MacLusky N., Sakamoto H., Eisenfeld A. Steroid-receptor proteins in nonepithelial malignancies of the ovary. Gynecol Oncol. 1983 ; 15: 305-315.
95. Schwartz PE, MacLusky N., Naftolin F., Eisenfeld A. Tamoxifeninduced increase in cytosol progestin receptor levels in a case of metastatic endometrial cancer. Gynecol Oncol. 1983 ; 16: 41-48.
96. Malik ST, Slevin ML Medroxyprogesterone acetate (MPA) in advanced granulosa cell tumours of the ovary-a new therapeutic approach ? Br J Cancer. 1991 ; 63: 410-411.
97. Briasoulis E., Karavasilis V., Pavlidis N. Megestrol activity in recurrent adult type granulosa cell tumour of the ovary. Ann Oncol. 1997 ; 8: 811-812.
98. Martikainen H., Penttinen J., Huhtaniemi I., Kauppila A. Gonadotropin-releasing hormone agonist analog therapy effective in ovarian granulosa cell malignancy. Gynecol Oncol. 1989 ; 35: 406-408.
99. Fishman A., Kudelka AP, Tresukosol D., et al. Leuprolide acetate for treating refractory or persistent ovarian granulosa cell tumor. J Reprod Med. 1996 ; 41: 393-396.