Neurally induced umbilical cord blood cells modestly repair injured spinal cords

NeuroReport

Volumn 19, Issue 13, 2008, Pages 1259-1263

  Cho, Sung Rae ^a   Yang, Mal Sook ^c   Yim, Sun Hee ^a   Park, Jin Hee ^a   Lee, Jong Eun ^c   Eom, Young Woo ^c   Jang, In Keun ^c   Kim, Hyo Eun ^c   Park, Joon Seong ^b   Kim, Hyun Ok ^a   Lee, Bae Hwan ^a   Park, Chang Il ^a   Kim, Young Jin ^c,d  

^a Yonsei University   (South Korea)

^b Departments of Laboratory Medicine   (South Korea)

^c Biomedical Research Institute   (South Korea)

^d Ajou University Medical CentSuwon   (South Korea)

Author keywords

Functional recovery; Multipotent progenitor cells; Neural induction; Spinal cord injury; Umbilical cord blood

Indexed keywords

CYCLOSPORIN A; KANAMYCIN; NERVE GROWTH FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; MYELIN BASIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CORD BLOOD STEM CELL TRANSPLANTATION; EVOKED SOMATOSENSORY RESPONSE; FUNCTIONAL STATUS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LOCOMOTION; MALE; NECROSIS; NONHUMAN; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RATING SCALE; SPINAL CORD INJURY; ANIMAL; ANIMAL BEHAVIOR; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; ELECTROPHYSIOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STEM CELL;

ANIMALS; BEHAVIOR, ANIMAL; CELL DIFFERENTIATION; CELLS, CULTURED; CORD BLOOD STEM CELL TRANSPLANTATION; ELECTROPHYSIOLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EVOKED POTENTIALS, SOMATOSENSORY; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MOTOR ACTIVITY; MYELIN BASIC PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD INJURIES; STEM CELLS;

EID: 52649085337     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283089234     Document Type: Article

References (16)

1. Chopp M, Zhang X, Li Y,Wang L, Chen J, Lu D, et al. Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport 2000; 11:3001-3005.
2. Sasaki M, Honmou O, Akiyama Y, Uede T, Hashi K, Kocsis J. Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 2001; 35:26-34.
3. Koshizuka S, Okada S, Okawa A, Koda M, Murasawa M, Hashimoto M, et al. Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice. J Neuropath Exp Neurol 2004; 63:64-72.
4. Saporta S, Kim J,Willing A, Fu E, Davis C, Sanberg P. Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior. J Hematother Stem Cell Res 2003; 12:271-278.
5. Zhao Z, Li H, Liu H, Lu S, Yang R, Zhang O, et al. Intraspinal transplantation of CD34 + human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant 2004; 13:113-122.
6. Kuh S, Cho Y, Yoon D, Kim K, Ha Y. Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat. Acta Neurochir 2005; 147:985-992.
7. Woodury D, Schwarz E, Prockop D, Black I. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000; 61:364-370.
8. Jang Y, Park J, Lee M, Yoon B, Yang Y, Yang S, et al. Retinoic acidmediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells. J Neurosci Res 2004; 75:573-584.
9. Jeong J, Gang E, Hong S, Hwang S, Kim S, Yang I, et al. Rapid neural differentiation of human cord blood-derived mesenchymal stem cells. Neuroreport 2004; 15:1731-1734.
10. Lu P, Jones L, Tuszynski M. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 2005; 191:344-360.
11. Lee M, Moon Y, Yang M, Kim S, Jang I, Eom Y, et al. Neural differentiation of novel multipotent progenitor cells from cryopreserved human umbilical cord blood. Biochem Biophys Res Commun 2007; 358:637-643.
12. Lee M, Choi J, Yang M, Moon Y, Park J, Kim H, et al. Mensenchymal stem cells from cryopreserved human umbilical cord blood. Biochem Biophys Res Commun 2004; 320:273-278.
13. Woodbury D, Reynolds K, Black I. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 2002; 96:908-917.
14. Tai M, Cheng H, Wu J, Liu Y, Lin P, Kuo J, et al. Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusion. Exp Neurol 2003; 183:508-515.
15. Tuszynski M, Gabriel K, Gage F, Suhr S, Meyer S, Rosetti A. Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neuritis after adult spinal cord injury. Exp Neurol 1996; 137:157-173.
16. Lu P, Jones L, Snyder E, Tuszynski M. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003; 181:115-129.