Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes

Neurochemical Research

Volumn 33, Issue 11, 2008, Pages 2263-2268

  Cupello, Aroldo ^a   Audenino, Daniela ^b,c   Scarrone, Simona ^a   Fornaro, Michele ^b   Gatta, Elena ^b   Fornaro, Pantaleo ^b   Albano, Claudio ^b  

^a CNR   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c Ospedale di Vercelli   (Italy)

Author keywords

Blood platelets; Epilepsy; Pseudoepilepsy; Serotonin; Serotonin transporter

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; ETIRACETAM; LAMOTRIGINE; OLANZAPINE; PAROXETINE; PHENOBARBITAL; SEROTONIN TRANSPORTER; TOPIRAMATE; VALPROIC ACID;

ADULT; AGED; ARTICLE; BRAIN DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPILEPSY; FEMALE; HOMEOSTASIS; HUMAN; LOW DRUG DOSE; MALE; MONOTHERAPY; PRIORITY JOURNAL; PSEUDOSEIZURE; SEIZURE; THROMBOCYTE MEMBRANE;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; BLOOD PLATELETS; CELL MEMBRANE; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED; PAROXETINE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRITIUM;

EID: 52549113969     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9708-7     Document Type: Article

References (22)

1. CL Scudder AG Karczmar GM Everett 1966 Brain cathecolamines and serotonin values in various strains and genera of mice and a possibile interpretation for the correlation of amine with electroshock latency and behaviour Int J Neuropharmacol 5 343 351
2. QS Yan PC Jobe JW Dailey 1993 Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats Eur J Pharmacol 252 105 112
3. PC Jobe RA Browning 2005 The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant not proconvulsant Epilepsy Behav 7 602 619
4. G Bagdy V Kecskemeti P Riba 2007 Serotonin and Epilepsy J Neurochem 100 857 873
5. JD Leander 1992 Fluoxetine, a selective serotonin uptake inhibitor, enhances the anticonvulsant effects of phenytoin, carbamazepine and ameltolide Epilepsia 33 573 576
6. A Pasini A Tortorella K Gale 1992 Anticonvulsant action of intranigral fluoxetine Brain Res 593 287 290
7. S Prendeville K Gale 1993 Anticonvulsant effect of fluoxetine on focally evoked limbic motor seizures in rats Epilepsia 34 381 384
8. Y Wada J Shiraishi M Nakamura 1995 Prolonged but not acute fluoxetine administration produces the inhibitory effect on hippocampal seizures in rats Psychopharmacology 118 305 309
9. E Favale V Rubino P Mainardi 1995 Anticonvulsant effect of fluoxetine in humans Neurology 45 1926 1927
10. E Favale D Audenino L Cocito 2003 The anticonvulsant effect of citalopram as an indirect evidence of serotoninergic impairment in human epileptogenesis Seizure 12 316 318
11. SM Paul M Rehavi P Skolnick 1981 Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter" Arch Gen Psychiat 38 1315 1317
12. SZ Langer E Zarifian M Briley 1982 High-affinity 3H-imipramine binding: a new biological marker in depression Pharmacopsychiatria 15 4 10
13. SZ Langer AM Galzin MF Poirier 1987 Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression J Recept Res 7 499 521
14. ET Mellerup I Errebo J Molin 1993 Platelet paroxetine binding and light therapy in winter depression J Affect Disord 29 11 15
15. R Uebelhack L Franke N Herold 2006 Brain and platelet serotonin transporter in humans-orrelation between [123I]-ADAM SPECT and serotonergic measurements in platelets Neurosci Lett 406 153 158
16. M Da Prada AM Cesura JM Launay 1988 Platelets as a model for neurones? Experientia 44 115 126
17. KP Lesch BL Wolozin DL Murphy 1993 Primary structure of human platelet serotonin uptake site: identity with the brain serotonin transporter J Neurochem 60 2319 2322
18. Rausch Jl ME Johnson J Li 2005 Serotonin transport kinetics correlated between human platelets and brain synaptosomes Psychopharmacology 180 391 398
19. A Cupello E Favale D Audenino 2005 Decrease of serotonin transporters in blood platelets after epileptic seizures Neurochem Res 30 425 428
20. C Albano A Cupello P Mainardi 2006 Successful treatment of epilepsy with serotonin reuptake inhibitors: proposed mechanism Neurochem Res 31 509 514
21. RP Lesser 2003 Treatment and outcome of psychogenic nonepileptic seizures Epilepsy Curr 3 198 200
22. M Reuber G Fernandez J Bauer 2002 Diagnostic delay in psychogenic nonepileptic seizures Neurology 58 493 495