The status and future of acupuncture clinical research

Journal of Alternative and Complementary Medicine

Volumn 14, Issue 7, 2008, Pages 861-869

  Napadow, Vitaly ^a,b   Ahn, Andrew ^b   Longhurst, John ^c   Lao, Lixing ^d   Stener Victorin, Elisabet ^e   Harris, Richard ^f   Langevin, Helene M ^g  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUPUNCTURE; CARDIOVASCULAR SYSTEM; CARPAL TUNNEL SYNDROME; CONFERENCE PAPER; CONNECTIVE TISSUE; ELECTROACUPUNCTURE; EMBRYO TRANSFER; ENDOCRINE DISEASE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FIBROMYALGIA; FUNDING; GYNECOLOGIC CARE; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INFLAMMATION; MEDICAL RESEARCH; MEDICAL SCHOOL; MEDICAL STUDENT; METABOLIC DISORDER; MUSCLE FUNCTION; NEEDLE; NERVE MEMBRANE; NERVOUS SYSTEM; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PHYSICIAN; PRIORITY JOURNAL;

ACUPUNCTURE THERAPY; ANIMALS; BIOMEDICAL RESEARCH; CLINICAL TRIALS AS TOPIC; DELIVERY OF HEALTH CARE, INTEGRATED; DIAGNOSTIC TECHNIQUES, NEUROLOGICAL; EVIDENCE-BASED MEDICINE; FORECASTING; HUMANS; INTERDISCIPLINARY COMMUNICATION; RESEARCH; RESEARCH DESIGN; SOCIETIES, MEDICAL; UNITED STATES;

EID: 52449133484     PISSN: 10755535     EISSN: None     Source Type: Journal    
DOI: 10.1089/acm.2008.SAR-3     Document Type: Conference Paper

References (78)

1. Dung, HC. Acupuncture points of the cervical plexus. Am Chin Med1984;12(1-4):94-105.
2. Bossy J. Morphological data concerning the acupuncture points and channel network. Acupunct Electrother Res 1984;9:79-106.
3. Liu Y, Varela M, Oswald R. The correspondence between some motor points and acupuncture loci. Am J Chin Med 1975;3:347-358.
4. Kellner G. On a vascularized nerve-ending corpuscle of the Krause end-organ type. Z Mikrosk Anat Forsch 1966;75:130-144.
5. Ciszek M, Szopinski J, Skrzypulec V. Investigations of morphological structure of acupuncture points and meridians. J Tradit Chin Med, 1985;5:289-292.
6. Langevin HM, Yandow JA. Relationship of acupuncture points and meridians to connective tissue planes. Anat Rec 2002;269:257-265.
7. Langevin HM, Churchill DL, Cipolla MJ. Mechanical signaling through connective tissue: A mechanism for the therapeutic effect of acupuncture. FASEB J 2001;15:2275-2282.
8. Langevin HM, Churchill DL, Fox JR, et al. Biomechanical response to acupuncture needling in humans. J Appl Physiol 2001;91:2471-2478.
9. Melzack R, Stillwell DM, Fox EJ. Trigger points and acupuncture points for pain: Correlations and implications [review]. Pain 1977;3:3-23.
10. Birch S, Felt B. Understanding Acupuncture. Edinburgh: Churchill Livingstone, Inc., 1999.
11. Darras, J-C, Vernejoul PD, Albarede P. Nuclear medicine and acupuncture: A study on the migration of radioactive tracers after injection at acupoints. Am J Acupunct 1992;20:245-256.
12. 99m. J Nucl Med 1992;33:403-407.
13. Ahn AC, Colbert AP, Anderson BJ, et al. Electrical properties of acupuncture points and meridians: A systematic review. Bioelectromagnetics 2008; 29:245-256.
14. Li P, Pitsillides KF, Rendig SV, et al. Reversal of reflex-induced myocardial ischemia by median nerve stimulation: A feline model of electroacupuncture. Circulation 1998;97:1186-1194.
15. Zhou W, Fu LW, Tjen-A-Looi SC, et al. Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses. J Appl Physiol 2005;98:872-880.
16. Chao DM, Shen LL, Tjen ALS, et al. Naloxone reverses inhibitory effect of electroacupuncture on sympathetic cardiovascular reflex responses. Am J Physiol 1999;276(6[pt2]):H2127-H2134.
17. Li P, Tjen-A-Looi SC, Longhurst JC. Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats. Auton Neurosci 2001;89(1-2):38-47.
18. Guo ZL, Moazzami AR, Longhurst JC. Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: Relation to opioid containing neurons. Brain Res 2004;1030:103-115.
19. Tjen-A-Looi SC, Li P, Longhurst JC. Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats. Am J Physiol Heart Circ Physiol 2007;293:H3627-H3635.
20. Crisostomo MM, Li P, Tjen-A-Looi SC, Longhurst JC. Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats. J Appl Physiol 2005;98:2056-2063.
21. Zhou WY, Tjen-A-Looi SC, Longhurst JC. Brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in rats. J Appl Physiol 2005;99:851-860.
22. Tjen-A-Looi SC, Li P, Longhurst JC. Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints. Am J Physiol Regul Integr Comp Physiol 2004;287:R852-R862.
23. Li P, Rowshan K, Crisostomo M, et al. Effect of electroacupuncture on pressor reflex during gastric distension. Am J Physiol Regul Integr Comp Physiol 2002;283:R1335-1345.
24. Tjen-A-Looi, S.C., P. Li, and J.C. Longhurst, Midbrain vlPAG inhibits rVLM cardiovascular sympathoexcitatory responses during electroacupuncture. Am J Physiol Heart Circ Physiol, 2006. 290(6): p. H2543-53.
25. Li P, Tjen-A-Looi SC, Longhurst JC. Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes. Am J Physiol Heart Circ Physiol 2006;290:H2535-H2542.
26. Guo ZL, Longhurst J.C. Expression of c-Fos in arcuate nucleus induced by electroacupuncture: Relations to neurons containing opioids and glutamate. Brain Res 2007;1166:65-76.
27. Zhou W, Fu LW, Guo ZL, Longhurst JC. Role of glutamate in the rostral ventrolateral medulla in acupuncture-related modulation of visceral reflex sympathoexcitation. Am J Physiol Heart Circ Physiol 2007;292:H1868-H1875.
28. Zhou W, Fu LW, Tjen-A-Looi SC, et al. Role of glutamate in a visceral sympathoexcitatory reflex in rostral ventrolateral medulla of cats. Am J Physiol Heart Circ Physiol 2006;291:H1309-H1318.
29. Tjen-A-Looi SC, Li P, Longhurst JC. Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neurons by electroacupuncture in cats. Auton Neurosci 2003;106:119-131.
30. Li P, Ayannusi O, Reid C, Longhurst JC. Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress. Clin Auton Res 2004;14:182-188.
31. Hsiao A-F, Tjen-A-Looi SC, Zhou W. Neural pathways of cardiovascular depressor reflex during gastric distension and its modulation by electroacupuncture. FASEB J 2008; in press.
32. Lao L, Zhang G, Wei F, et al. Electro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal Fos protein expression in rats with persistent inflammation. J Pain 2001;2:111-117.
33. Lao L, Zhang RX, Zhang G, et al. A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats. Brain Res 2004;1020(1-2):18-29.
34. Li A, Zhang RX, Wang Y, et al. Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation. BMC Complement Altern Med 2007;7:27.
35. Zhang RX, Lao L, Wang X, et al. Electroacupuncture attenuates inflammation in a rat model. J Altern Complement Med 2005;11:135-142.
36. Zhang RX, Lao L, Wang L, et al. Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation. Brain Res 2004;1020(1-2):12-17.
37. Liu B., Zhang RX, Wang L, et al. Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats. Brain Res 2005;1044:87-92.
38. Zhang RX, Wang L, Liu B, et al. Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation. Brain Res 2005;1048(1-2):235-240.
39. Li A, Wang Y, Xin J, et al. Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system. Brain Res 2007;1186:171-179.
40. Stener-Victorin E, Waldenstrom U, Andersson SA, Wikland M. Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum Reprod 1996;1:1314-1317.
41. Stener-Victorin E, Fujisawa S, Kurosawa M. Ovarian blood flow responses to electroacupuncture stimulation depend on estrous cycle and on site and frequency of stimulation in anesthetized rats. J Appl Physiol 2006;101:84-91.
42. Stener-Victorin E, Kobayashi R, Kurosawa M. Ovarian blood flow responses to electro-acupuncture stimulation at different frequencies and intensities in anaesthetized rats. Auton Neurosci 2003;108(1-2):50-56.
43. Manneras L, Cajander S, Holmang A, et al. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology 2007;148:781-3791.
44. Stener-Victorin E, Waldenstrom U, Tagnfors U, et al. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand 2000;79:180-188.
45. Chen BY. Acupuncture normalizes dysfunction of hypothalamic-pituitary- ovarian axis. Acupunct Electrother Res 1997;22:97-108.
46. Gerhard I, Postneek F. Auricular acupuncture in the treatment of female infertility. Gynecol Endocrinol 1992;6:171-181.
47. Stener-Victorin E, Lindholm C. Immunity and beta-endorphin concentrations in hypothalamus and plasma in rats with steroid-induced polycystic ovaries: Effect of low-frequency electroacupuncture. Biol Reprod 2004;70:329-333.
48. Manni L, Lundeberg T, Holmang A, et al. Effect of electroacupuncture on ovarian expression of alpha (1)- and beta (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Reprod Biol Endocrinol 2005;3:21.
49. Mannerås L, L, Jonsdottir H, Holmäng A, et al. Low frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone- induced polycystic ovary syndrome. Endocrinology 2008;149:3559-3568.
50. Stener-Victorin E, Waldenstrom U, Nilsson L, et al. A prospective randomized study of electro-acupuncture versus alfentanil as anaesthesia during oocyte aspiration in in-vitro fertilization. Hum Reprod 1999;14:2480-2484.
51. Westergaard LG, Mao Q, Krogslund M, et al. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: A prospective, randomized trial. Fertil Steril 2006;85:1341-1346.
52. Anderson BJ, Haimovici F, Ginsburg ES, et al. In vitro fertilization and acupuncture: Clinical efficacy and mechanistic basis. Altern Ther Health Med 2007;13:38-48.
53. Anderson BJ, Rosenthal L. Acupuncture and IVF controversies. Fertil Steril 2007;87:1000.
54. Manheimer E, Zhang G, Udoff L, et al. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: Systematic review and meta-analysis. BMJ 2008;336:545-549.
55. Pinborg A, Loft A, Andersen AN. Acupuncture with in vitro fertilisation. BMJ 2008;336:517-518.
56. Dhond RP, Kettner N, Napadow V. Neuroimaging acupuncture effects in the human brain. J Altern Complement Med 2007;13:603-616.
57. Hui KK, Liu J, Makris N, et al. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects. Hum Brain Mapp 2000;9:13-25.
58. Hui KK, Liu J, Marina O, et al. The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage 2005;27:479-496.
59. Napadow V, Makris N, Liu J, et al. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Hum Brain Mapp 2005;24:193-205.
60. Wu MT, Hsieh JC, Xiong J, et al. Central nervous pathway for acupuncture stimulation: Localization of processing with functional MR imaging of the brain - preliminary experience. Radiology 1999;212:133-141.
61. Pariente J, White P, Frackowiak RS, Lewith G. Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture. Neuroimage 2005;25:1161-1167.
62. Kong J, Gollub RL,. Rosman IS, et al. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci 2006;26:381-388.
63. Dhond RP, Yeh C, Park K, et al. Acupuncture modulates resting state connectivity in default and sensorimotor brain networks. Pain 2008;136:407-418.
64. Napadow, V., J. Liu, M. Li, N. Kettner, A. Ryan, K.K. Kwong, K.K. Hui, and J.F. Audette, Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture. Hum Brain Mapp 2007;28:159-171.
65. Napadow V, Kettner N, Ryan A, et al. Somatosensory cortical plasticity in carpal tunnel syndrome - a cross-sectional fMRI evaluation. Neuroimage 2006;1:520-530.
66. Napadow V, Kettner N, Liu J, et al. Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome. Pain 2007;130:254-266.
67. Wolfe F, Ross K, Anderson J, et al. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995;38:19-28.
68. Cook DB, Lange G, Ciccone DS, et al. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol 2004;31:364-378.
69. Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002;46:1333-1343.
70. Harris RE, Clauw DJ, Scott DJ, et al. Decreased central mu-opioid receptor availability in fibromyalgia. J Neurosci 2007;27:10000-10006.
71. Assefi NP, Sherman KJ, Jacobsen C, et al. A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia. Ann Intern Med 2005;143:10-19.
72. Deluze C, Bosia L, Zirbs A, et al. Electroacupuncture in fibromyalgia: Results of a controlled trial. BMJ 1992;305:1249-1252.
73. Harris RE, Tian X, Williams DA, et al. Treatment of fibromyalgia with formula acupuncture: Investigation of needle placement, needle stimulation, and treatment frequency. J Altern Complement Med 2005;11:663-671.
74. Benedetti F, Amanzio M. The neurobiology of placebo analgesia: From endogenous opioids to cholecystokinin. Prog Neurobiol 1997;52:109-125.
75. Chen XH, Geller EB, Adler MW. Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats. J Pharmacol Exp Ther 1996;277:654-660.
76. Shah JP, Danoff JV, Desai MJ, et al. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil 2008;89:16-23.
77. Langevin HM, Bouffard NA, Badger GJ, et al. Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: Evidence for a mechanotransduction-based mechanism. J Cell Physiol 2006;207:767-774.
78. Langevin HM, Bouffard NA, Churchill DL, Badger GJ. Connective tissue fibroblast response to acupuncture: Dose-dependent effect of bidirectional needle rotation. J Altern Complement Med 2007;13:355-360.