메뉴 건너뛰기




Volumn 8, Issue SUPPL. 2, 2008, Pages

Clinical experience with epothilones in patients with breast cancer

Author keywords

Antimicrotubule agents; Ixabepilone; P glycoprotein; Triple negative breast cancer

Indexed keywords

21 AMINOEPOTHILONE B; ANTHRACYCLINE; BEVACIZUMAB; BIOLOGICAL MARKER; CAPECITABINE; CARBOPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; ESTROGEN RECEPTOR; IXABEPILONE; PACLITAXEL; PROGESTERONE RECEPTOR; SAGOPILONE; TAXANE DERIVATIVE; TRASTUZUMAB; TUBULIN MODULATOR;

EID: 52449115718     PISSN: 15268209     EISSN: None     Source Type: Journal    
DOI: 10.3816/CBC.2008.s.003     Document Type: Article
Times cited : (6)

References (64)
  • 1
    • 0346847742 scopus 로고    scopus 로고
    • Is breast cancer survival improving?
    • Giordano SH, Buzdar AU, Smith TL, et al. Is breast cancer survival improving? Cancer 2004; 100:44-52.
    • (2004) Cancer , vol.100 , pp. 44-52
    • Giordano, S.H.1    Buzdar, A.U.2    Smith, T.L.3
  • 2
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365:1687-717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 3
    • 0037445132 scopus 로고    scopus 로고
    • Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer
    • Henderson IC, Berry DA, Demetri GD, et al. Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J Clin Oncol 2003; 21:976-83.
    • (2003) J Clin Oncol , vol.21 , pp. 976-983
    • Henderson, I.C.1    Berry, D.A.2    Demetri, G.D.3
  • 4
    • 21144435932 scopus 로고    scopus 로고
    • Adjuvant docetaxel for nodepositive breast cancer
    • Martin M, Pienkowski T, Mackey J, et al. Adjuvant docetaxel for nodepositive breast cancer. N Engl J Med 2005; 352:2302-13.
    • (2005) N Engl J Med , vol.352 , pp. 2302-2313
    • Martin, M.1    Pienkowski, T.2    Mackey, J.3
  • 5
    • 33745864289 scopus 로고    scopus 로고
    • Biomarkers and multiple drug resistance in breast cancer
    • O'Driscoll L, Clynes M. Biomarkers and multiple drug resistance in breast cancer. Curr Cancer Drug Targets 2006; 6:365-84.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 365-384
    • O'Driscoll, L.1    Clynes, M.2
  • 6
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005; 205:275-92.
    • (2005) J Pathol , vol.205 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 7
    • 0027965381 scopus 로고
    • Salvage therapies in women who fail to respond to first-line treatment with fluorouracil, epirubicin, and cyclophosphamide for advanced breast cancer
    • Porkka K, Blomqvist C, Rissanen P, et al. Salvage therapies in women who fail to respond to first-line treatment with fluorouracil, epirubicin, and cyclophosphamide for advanced breast cancer. J Clin Oncol 1994; 12:1639-47.
    • (1994) J Clin Oncol , vol.12 , pp. 1639-1647
    • Porkka, K.1    Blomqvist, C.2    Rissanen, P.3
  • 8
    • 0033050165 scopus 로고    scopus 로고
    • Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer
    • Blum JL, Jones SE, Buzdar AU, et al. Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer. J Clin Oncol 1999; 17:485-93.
    • (1999) J Clin Oncol , vol.17 , pp. 485-493
    • Blum, J.L.1    Jones, S.E.2    Buzdar, A.U.3
  • 9
    • 10744229320 scopus 로고    scopus 로고
    • Multicentre, phase II study evaluating capecitabine monotherapy in patients with anthracyclineand taxane-pretreated metastatic breast cancer
    • Fumoleau P, Largillier R, Clippe C, et al. Multicentre, phase II study evaluating capecitabine monotherapy in patients with anthracyclineand taxane-pretreated metastatic breast cancer. Eur J Cancer 2004; 40:536-42.
    • (2004) Eur J Cancer , vol.40 , pp. 536-542
    • Fumoleau, P.1    Largillier, R.2    Clippe, C.3
  • 10
    • 0346694519 scopus 로고    scopus 로고
    • The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC)
    • Abstract 766
    • Hillan KJ, Koeppen HK, Tobin P, et al. The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC). Proc Am Soc Oncol 2003; 22:191. (Abstract 766).
    • (2003) Proc Am Soc Oncol , vol.22 , pp. 191
    • Hillan, K.J.1    Koeppen, H.K.2    Tobin, P.3
  • 11
    • 9744278998 scopus 로고    scopus 로고
    • Efficacy and safety of single agent capecitabine in pretreated metastatic breast cancer patients from the French compassionate use program
    • Pierga JY, Fumoleau P, Brewer Y, et al. Efficacy and safety of single agent capecitabine in pretreated metastatic breast cancer patients from the French compassionate use program. Breast Cancer Res Treat 2004; 88:117-29.
    • (2004) Breast Cancer Res Treat , vol.88 , pp. 117-129
    • Pierga, J.Y.1    Fumoleau, P.2    Brewer, Y.3
  • 12
    • 0041508753 scopus 로고    scopus 로고
    • Multicenter phase II study of oral capecitabine (Xeloda()) in patients with meta-static breast cancer relapsing after treatment with a taxane-contain-ing therapy
    • Reichardt P, Von Minckwitz G, Thuss-Patience PC, et al. Multicenter phase II study of oral capecitabine (Xeloda(")) in patients with meta-static breast cancer relapsing after treatment with a taxane-contain-ing therapy. Ann Oncol 2003; 14:1227-33.
    • (2003) Ann Oncol , vol.14 , pp. 1227-1233
    • Reichardt, P.1    Von Minckwitz, G.2    Thuss-Patience, P.C.3
  • 13
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag DM, McQueney PA, Zhu J, et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995; 55:2325-33.
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 14
    • 0037975662 scopus 로고    scopus 로고
    • Understanding tubulin-Taxol interactions: Mutations that impart Taxol binding to yeast tubulin
    • Gupta ML, Jr, Bode CJ, Georg GI, et al. Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin. Proc Natl Acad Sci U S A 2003; 100:6394-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6394-6397
    • Gupta Jr, M.L.1    Bode, C.J.2    Georg, G.I.3
  • 15
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • Lee FY, Borzilleri R, Fairchild CR, et al. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 2001; 7:1429-37.
    • (2001) Clin Cancer Res , vol.7 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 16
    • 34247170561 scopus 로고    scopus 로고
    • The Pat-21 breast cancer model derived from a patient with primary Taxol® resistance recapitulates the phenotype of its origin, has altered beta-tubulin expression and is sensitive to ixabepi-lone
    • Abstract LB-280
    • Jordan MA, Miller H P, Ni L, et al. The Pat-21 breast cancer model derived from a patient with primary Taxol® resistance recapitulates the phenotype of its origin, has altered beta-tubulin expression and is sensitive to ixabepi-lone Proc Am Assoc Cancer Res 2006; 47:Abstract LB-280.
    • (2006) Proc Am Assoc Cancer Res , vol.47
    • Jordan, M.A.1    Miller, H.P.2    Ni, L.3
  • 18
    • 0037362355 scopus 로고    scopus 로고
    • ATP binding cassette transporters and drug resistance in breast cancer
    • Leonessa F, Clarke R. ATP binding cassette transporters and drug resistance in breast cancer. Endocr Relat Cancer 2003; 10:43-73.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 43-73
    • Leonessa, F.1    Clarke, R.2
  • 19
    • 34047212584 scopus 로고    scopus 로고
    • Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas
    • Aghajanian C, Burris HA, 3rd, Jones S, et al. Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas. J Clin Oncol 2007; 25:1082-8.
    • (2007) J Clin Oncol , vol.25 , pp. 1082-1088
    • Aghajanian, C.1    Burris 3rd, H.A.2    Jones, S.3
  • 20
    • 24344450233 scopus 로고    scopus 로고
    • Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design
    • Gadgeel SM, Wozniak A, Boinpally RR, et al. Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design. Clin Cancer Res 2005; 11:6233-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 6233-6239
    • Gadgeel, S.M.1    Wozniak, A.2    Boinpally, R.R.3
  • 21
    • 12144285977 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
    • Mani S, McDaid H, Hamilton A, et al. Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res 2004; 10:1289-98.
    • (2004) Clin Cancer Res , vol.10 , pp. 1289-1298
    • Mani, S.1    McDaid, H.2    Hamilton, A.3
  • 22
    • 84898689172 scopus 로고    scopus 로고
    • Bunnell C, Klimovsky J, Thomas E. Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline. J Clin Oncol 2006; 24(18 suppl):568s (Abstract 10511).
    • Bunnell C, Klimovsky J, Thomas E. Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline. J Clin Oncol 2006; 24(18 suppl):568s (Abstract 10511).
  • 23
    • 34548149645 scopus 로고    scopus 로고
    • Predictive biomarker discovery and validation for the targeted chemotherapeutic ixabepilone
    • 18 suppl):123s Abstract 3011
    • Lee H, Xu L, Wu S, et al. Predictive biomarker discovery and validation for the targeted chemotherapeutic ixabepilone. J Clin Oncol 2006; 24(18 suppl):123s (Abstract 3011).
    • (2006) J Clin Oncol , pp. 24
    • Lee, H.1    Xu, L.2    Wu, S.3
  • 24
    • 34548157209 scopus 로고    scopus 로고
    • Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
    • Perez EA, Lerzo G, Pivot X, et al. Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol 2007; 25:3407-14.
    • (2007) J Clin Oncol , vol.25 , pp. 3407-3414
    • Perez, E.A.1    Lerzo, G.2    Pivot, X.3
  • 25
    • 34548179878 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepi- lone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy
    • Roche H, Yelle L, Cognetti F, et al. Phase II clinical trial of ixabepi- lone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J Clin Oncol 2007; 25:3415-20.
    • (2007) J Clin Oncol , vol.25 , pp. 3415-3420
    • Roche, H.1    Yelle, L.2    Cognetti, F.3
  • 26
    • 34548187738 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
    • Thomas E, Tabernero J, Fornier M, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol 2007; 25:3399-406.
    • (2007) J Clin Oncol , vol.25 , pp. 3399-3406
    • Thomas, E.1    Tabernero, J.2    Fornier, M.3
  • 27
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and tax-ane treatment
    • Thomas ES, Gomez HL, Li RK, et al. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and tax-ane treatment. J Clin Oncol 2007; 25:5210-7.
    • (2007) J Clin Oncol , vol.25 , pp. 5210-5217
    • Thomas, E.S.1    Gomez, H.L.2    Li, R.K.3
  • 28
    • 0037132372 scopus 로고    scopus 로고
    • Docetaxel vs 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure
    • Bonneterre J, Roche H, Monnier A, et al. Docetaxel vs 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure. Br J Cancer 2002; 87:1210-5.
    • (2002) Br J Cancer , vol.87 , pp. 1210-1215
    • Bonneterre, J.1    Roche, H.2    Monnier, A.3
  • 29
    • 24944507764 scopus 로고    scopus 로고
    • Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer
    • Jones SE, Erban J, Overmoyer B, et al. Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J Clin Oncol 2005; 23:5542-51.
    • (2005) J Clin Oncol , vol.23 , pp. 5542-5551
    • Jones, S.E.1    Erban, J.2    Overmoyer, B.3
  • 30
    • 0032949449 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus mitomycin plus vinblastine in patients with metastatic breast cancer progressing despite previous anthracycline-containing chemotherapy. 304 Study Group
    • Nabholtz JM, Senn HJ, Bezwoda WR, et al. Prospective randomized trial of docetaxel versus mitomycin plus vinblastine in patients with metastatic breast cancer progressing despite previous anthracycline-containing chemotherapy. 304 Study Group. J Clin Oncol 1999; 17:1413-24.
    • (1999) J Clin Oncol , vol.17 , pp. 1413-1424
    • Nabholtz, J.M.1    Senn, H.J.2    Bezwoda, W.R.3
  • 31
    • 17344390083 scopus 로고    scopus 로고
    • Docetaxel compared with sequential methotrexate and 5-fluorouracil in patients with advanced breast cancer after anthracycline failure: A randomised phase III study with crossover on progression by the Scandinavian Breast Group
    • Sjostrom J, Blomqvist C, Mouridsen H, et al. Docetaxel compared with sequential methotrexate and 5-fluorouracil in patients with advanced breast cancer after anthracycline failure: a randomised phase III study with crossover on progression by the Scandinavian Breast Group. Eur J Cancer 1999; 35:1194-201.
    • (1999) Eur J Cancer , vol.35 , pp. 1194-1201
    • Sjostrom, J.1    Blomqvist, C.2    Mouridsen, H.3
  • 32
    • 0031758794 scopus 로고    scopus 로고
    • A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer
    • Valero V, Jones SE, Von Hoff DD, et al. A phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer. J Clin Oncol 1998; 16:3362-8.
    • (1998) J Clin Oncol , vol.16 , pp. 3362-3368
    • Valero, V.1    Jones, S.E.2    Von Hoff, D.D.3
  • 33
    • 84898697361 scopus 로고    scopus 로고
    • Lee FY, Camuso S, Castenada S, et al. Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts. J Clin Oncol 2006; 24(18 suppl):597s (Abstract 12017).
    • Lee FY, Camuso S, Castenada S, et al. Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts. J Clin Oncol 2006; 24(18 suppl):597s (Abstract 12017).
  • 34
    • 84898699384 scopus 로고    scopus 로고
    • Lee FY, Castaneda S, Inigo I, et al. Ixabepilone (BMS-247550) plus trastuzumab combination chemotherapy induces synergistic antitumor efficacy in HER2 dependent breast cancers and is accompanied by modulation of molecular response markers. J Clin Oncol 2005; 23(16 suppl):19s (Abstract 561).
    • Lee FY, Castaneda S, Inigo I, et al. Ixabepilone (BMS-247550) plus trastuzumab combination chemotherapy induces synergistic antitumor efficacy in HER2 dependent breast cancers and is accompanied by modulation of molecular response markers. J Clin Oncol 2005; 23(16 suppl):19s (Abstract 561).
  • 36
    • 84898696792 scopus 로고    scopus 로고
    • Vahdat L, Bunnell C, Schwartzberg L, et al. Ixabepilone is effective in combination with capecitabine in ER, PR, HER-2 negative (triple negative) patients (pts) resistant to taxanes and anthracyclines: final results from a breast cancer exploratory program. Ann Oncol 2006; 17(suppl 9):Abstract 159P.
    • Vahdat L, Bunnell C, Schwartzberg L, et al. Ixabepilone is effective in combination with capecitabine in ER, PR, HER-2 negative (triple negative) patients (pts) resistant to taxanes and anthracyclines: final results from a breast cancer exploratory program. Ann Oncol 2006; 17(suppl 9):Abstract 159P.
  • 37
    • 33750705613 scopus 로고    scopus 로고
    • Success of neoadjuvant chemotherapy in conversion of mastectomy to breast conservation surgery
    • Kaufmann P, Dauphine CE, Vargas M P, et al. Success of neoadjuvant chemotherapy in conversion of mastectomy to breast conservation surgery. Am Surg 2006; 72:935-8.
    • (2006) Am Surg , vol.72 , pp. 935-938
    • Kaufmann, P.1    Dauphine, C.E.2    Vargas, M.P.3
  • 38
    • 33845494854 scopus 로고    scopus 로고
    • Gene expression profiles as predictors of response to neoadjuvant taxotere and adriamycin/cytoxan: A prospective randomized multicenter trial in breast cancer
    • Abstract 304
    • Chang J, Hilsenbeck S, Yee D, et al. Gene expression profiles as predictors of response to neoadjuvant taxotere and adriamycin/cytoxan: a prospective randomized multicenter trial in breast cancer. Breast Cancer Res and Treat 2005; 94(suppl 1):S31 (Abstract 304).
    • (2005) Breast Cancer Res and Treat , vol.94 , Issue.SUPPL. 1
    • Chang, J.1    Hilsenbeck, S.2    Yee, D.3
  • 39
    • 23844464866 scopus 로고    scopus 로고
    • Neoadjuvant docetaxel followed by adjuvant doxorubicin and cyclophosphamide in patients with stage III breast cancer
    • Gradishar WJ, Wedam SB, Jahanzeb M, et al. Neoadjuvant docetaxel followed by adjuvant doxorubicin and cyclophosphamide in patients with stage III breast cancer. Ann Oncol 2005; 16:1297-304.
    • (2005) Ann Oncol , vol.16 , pp. 1297-1304
    • Gradishar, W.J.1    Wedam, S.B.2    Jahanzeb, M.3
  • 40
    • 0642347622 scopus 로고    scopus 로고
    • The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: Preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27
    • Bear HD, Anderson S, Brown A, et al. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 2003; 21:4165-74.
    • (2003) J Clin Oncol , vol.21 , pp. 4165-4174
    • Bear, H.D.1    Anderson, S.2    Brown, A.3
  • 41
    • 29344467956 scopus 로고    scopus 로고
    • Feasibility and tolerability of sequential doxorubicin/paclitaxel followed by cyclophosphamide, methotrexate, and fluorouracil and its effects on tumor response as preoperative therapy
    • Gianni L, Baselga J, Eiermann W, et al. Feasibility and tolerability of sequential doxorubicin/paclitaxel followed by cyclophosphamide, methotrexate, and fluorouracil and its effects on tumor response as preoperative therapy. Clin Cancer Res 2005; 11:8715-21.
    • (2005) Clin Cancer Res , vol.11 , pp. 8715-8721
    • Gianni, L.1    Baselga, J.2    Eiermann, W.3
  • 42
    • 24944542869 scopus 로고    scopus 로고
    • Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks
    • Green MC, Buzdar AU, Smith T, et al. Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks. J Clin Oncol 2005; 23:5983-92.
    • (2005) J Clin Oncol , vol.23 , pp. 5983-5992
    • Green, M.C.1    Buzdar, A.U.2    Smith, T.3
  • 43
    • 34247161458 scopus 로고    scopus 로고
    • Predicting response to ixabepi-lone: Genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (BC)
    • Abstract 305
    • Baselga J, Gianni L, Llombart A, et al. Predicting response to ixabepi-lone: genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (BC). Breast Cancer Res Treat 2005; 94(suppl 1):(Abstract 305).
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL. 1
    • Baselga, J.1    Gianni, L.2    Llombart, A.3
  • 44
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey LA, Dees EC, Sawyer L, et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007; 13:2329-34.
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 45
    • 84898695350 scopus 로고    scopus 로고
    • Roche H, Perez E, Llombart Cussac A, et al. Ixabepilone, an epothilone B analog, is effective in ER, PR, HER-2 negative (triple negative) patients (pts): data from neoadjuvant and metastatic breast cancer (MBC) trials. Ann Oncol 2006; 17(suppl 9):(Abstract 256P).
    • Roche H, Perez E, Llombart Cussac A, et al. Ixabepilone, an epothilone B analog, is effective in ER, PR, HER-2 negative (triple negative) patients (pts): data from neoadjuvant and metastatic breast cancer (MBC) trials. Ann Oncol 2006; 17(suppl 9):(Abstract 256P).
  • 46
    • 84898690240 scopus 로고    scopus 로고
    • ClinicalTrials.gov [Web site]. Epothilone (Ixabepilone) Plus Capecitabine Versus Capecitabine Alone in Patients With Advanced Breast Cancer. Available at: http://clinicaltrials.gov/ct2/show/ NCT00082433. Accessed: January 4, 2008.
    • ClinicalTrials.gov [Web site]. Epothilone (Ixabepilone) Plus Capecitabine Versus Capecitabine Alone in Patients With Advanced Breast Cancer. Available at: http://clinicaltrials.gov/ct2/show/ NCT00082433. Accessed: January 4, 2008.
  • 47
    • 34147112848 scopus 로고    scopus 로고
    • Targeting the microtubules in breast cancer beyond taxanes: The epothilones
    • Cortes J, Baselga J. Targeting the microtubules in breast cancer beyond taxanes: the epothilones. Oncologist 2007; 12:271-80.
    • (2007) Oncologist , vol.12 , pp. 271-280
    • Cortes, J.1    Baselga, J.2
  • 48
    • 3042701597 scopus 로고    scopus 로고
    • Epothilones: Mechanism of action and biologic activity
    • Goodin S, Kane M P, Rubin EH. Epothilones: mechanism of action and biologic activity. J Clin Oncol 2004; 22:2015-25.
    • (2004) J Clin Oncol , vol.22 , pp. 2015-2025
    • Goodin, S.1    Kane, M.P.2    Rubin, E.H.3
  • 49
    • 38449120471 scopus 로고    scopus 로고
    • Novel tubulin-targeting agents: Anticancer activity and pharmacologic profile of epothilones and related analogues
    • suppl 5:v9-15
    • Fumoleau P, Coudert B, Isambert N, et al. Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. Ann Oncol 2007; 18 (suppl 5):v9-15.
    • (2007) Ann Oncol , pp. 18
    • Fumoleau, P.1    Coudert, B.2    Isambert, N.3
  • 50
    • 41849145265 scopus 로고    scopus 로고
    • ZK-EPO, a novel synthetic epothilone B analog, significantly inhibits tumor growth in both nonresistant and resistant breast cancer models
    • Abstract 1072
    • Klar U, Buchmann B, Schwede W, et al. ZK-EPO, a novel synthetic epothilone B analog, significantly inhibits tumor growth in both nonresistant and resistant breast cancer models. Breast Cancer Res and Treat 2005; 94(suppl 1):S64 (Abstract 1072).
    • (2005) Breast Cancer Res and Treat , vol.94 , Issue.SUPPL. 1
    • Klar, U.1    Buchmann, B.2    Schwede, W.3
  • 51
    • 33646547391 scopus 로고    scopus 로고
    • A Phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors
    • 16 suppl):147s Abstract 2051
    • Schmid P, Kiewe D, Kuehnhardt A, et al. A Phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors. J Clin Oncol 2005; 23 (16 suppl):147s (Abstract 2051).
    • (2005) J Clin Oncol , pp. 23
    • Schmid, P.1    Kiewe, D.2    Kuehnhardt, A.3
  • 54
    • 0347325036 scopus 로고    scopus 로고
    • Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days
    • Abstract 515
    • Mekhail T, Chung C, Holden S, et al. Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days Proc Am Soc Clin Oncol 2003; 22:129 (Abstract 515).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 129
    • Mekhail, T.1    Chung, C.2    Holden, S.3
  • 55
    • 21244499905 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic (PK) study of the novel epothilone BMS-310705 in patients (pts) with advanced solid cancer
    • Abstract 519
    • Sessa C, Perotti A, Malossi A, et al. Phase I and pharmacokinetic (PK) study of the novel epothilone BMS-310705 in patients (pts) with advanced solid cancer. Proc Am Soc Clin Oncol 2003; 22:130 (Abstract 519).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 130
    • Sessa, C.1    Perotti, A.2    Malossi, A.3
  • 56
    • 33750379152 scopus 로고    scopus 로고
    • A phase II study of KOS-862 (epothilone D) in anthracycline and taxane pretreated meta- static breast cancer: Updated results
    • Abstract 1087
    • Buzdar A, Silverman P, Kaufman PA, et al. A phase II study of KOS-862 (epothilone D) in anthracycline and taxane pretreated meta- static breast cancer: updated results. Breast Cancer Res Treat 2005; 94(suppl 1):(Abstract 1087).
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL. 1
    • Buzdar, A.1    Silverman, P.2    Kaufman, P.A.3
  • 57
    • 38749090643 scopus 로고    scopus 로고
    • A phase I trial of weekly combination KOS-862 (epothilone D) and trastuzumab in HER-2 overexpressing malignancies
    • 86s Abstract 2028
    • Cortes J, Climent MA, Gomez P, et al. A phase I trial of weekly combination KOS-862 (epothilone D) and trastuzumab in HER-2 overexpressing malignancies. J Clin Oncol 2006; 24(suppl):86s (Abstract 2028).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Cortes, J.1    Climent, M.A.2    Gomez, P.3
  • 58
    • 84898693668 scopus 로고    scopus 로고
    • ClinicalTrials.gov [Web site]. A Phase II Combination of Trastuzumab and Ixabepilone Versus Trastuzumab and Docetaxel in Patients With Advanced and/or Metastatic Breast Cancer. Available at: http://clinical-trials.gov/ct2/show/ NCT00490646. Accessed: January 4, 2008.
    • ClinicalTrials.gov [Web site]. A Phase II Combination of Trastuzumab and Ixabepilone Versus Trastuzumab and Docetaxel in Patients With Advanced and/or Metastatic Breast Cancer. Available at: http://clinical-trials.gov/ct2/show/ NCT00490646. Accessed: January 4, 2008.
  • 59
    • 84898695426 scopus 로고    scopus 로고
    • ClinicalTrials.gov [Web site]. A Trial of 2 Schedules of Ixabepilone Plus Bevacizumab and Paclitaxel Plus Bevacizumab for Breast Cancer. Available at: http://clinicaltrials.gov/ct2/show/NCT00370552. Accessed: January 4, 2008.
    • ClinicalTrials.gov [Web site]. A Trial of 2 Schedules of Ixabepilone Plus Bevacizumab and Paclitaxel Plus Bevacizumab for Breast Cancer. Available at: http://clinicaltrials.gov/ct2/show/NCT00370552. Accessed: January 4, 2008.
  • 60
    • 0000155381 scopus 로고    scopus 로고
    • A Phase I Clinical and Pharmacokinetic Study of EPO906 (Epothilone B), Given Every Three Weeks, in Patients with Advanced Solid Tumors
    • Abstract 429
    • Calvert PM, O'Neill V, Twelves C, et al. A Phase I Clinical and Pharmacokinetic Study of EPO906 (Epothilone B), Given Every Three Weeks, in Patients with Advanced Solid Tumors. Proc Am Soc Clin Oncol 2001; 20:(Abstract 429).
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Calvert, P.M.1    O'Neill, V.2    Twelves, C.3
  • 61
    • 33644831567 scopus 로고    scopus 로고
    • Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors
    • Rubin EH, Rothermel J, Tesfaye F, et al. Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors. J Clin Oncol 2005; 23:9120-9.
    • (2005) J Clin Oncol , vol.23 , pp. 9120-9129
    • Rubin, E.H.1    Rothermel, J.2    Tesfaye, F.3
  • 62
    • 8344260820 scopus 로고    scopus 로고
    • Phase I study using continuous intravenous (CI) KOS-862 (Epothilone D)
    • patients with solid tumors, 14 suppl):133 Abstract 2024
    • Holen KD, Syed S, Hannah AL, et al. Phase I study using continuous intravenous (CI) KOS-862 (Epothilone D) in patients with solid tumors. J Clin Oncol 2004; 22(14 suppl):133 (Abstract 2024).
    • (2004) J Clin Oncol , pp. 22
    • Holen, K.D.1    Syed, S.2    Hannah, A.L.3
  • 63
    • 2442505920 scopus 로고    scopus 로고
    • KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies
    • Abstract 539
    • Piro LD, Rosen LS, Parson M, et al. KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies. Proc Am Soc Clin Oncol 2003; 22:135 (Abstract 539).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 135
    • Piro, L.D.1    Rosen, L.S.2    Parson, M.3
  • 64
    • 3142755834 scopus 로고    scopus 로고
    • KOS-862 (Epothilone D): Phase 1 dose escalating and pharmacokinetic (PK) study in patients with advanced malignancies
    • Abstract 894
    • Spriggs DR, Dupont J, Pezzulli S, et al. KOS-862 (Epothilone D): Phase 1 dose escalating and pharmacokinetic (PK) study in patients with advanced malignancies Proc Am Soc Clin Oncol 2003; 22:223 (Abstract 894).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 223
    • Spriggs, D.R.1    Dupont, J.2    Pezzulli, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.