Development of new bone cement utilizing low toxicity monomers

Journal of Medical and Dental Sciences

Volumn 55, Issue 2, 2008, Pages 189-196

  Ono, Satoshi ^a   Kadoma, Yoshinori ^a   Morita, Sadao ^a   Takakuda, Kazuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

2 ethylhexyl methacrylate; Bone cement; Cyclohexyl methacrylate; Methyl methacrylate; Monomer toxicity

Indexed keywords

BONE CEMENT; METHACRYLIC ACID DERIVATIVE; METHACRYLIC ACID METHYL ESTER; POLY(ETHYLMETHACRYLATE); POLYMER; TRIMETHYLOLPROPANE TRIMETHACRYLATE;

ANIMAL; ARTICLE; BONE MARROW; CHEMISTRY; COMPRESSIVE STRENGTH; DRUG EFFECT; FEMALE; FEMUR; LD 50; MATERIALS TESTING; MECHANICAL STRESS; RAT; SOLUBILITY; SPRAGUE DAWLEY RAT; TEMPERATURE;

ANIMALS; BONE CEMENTS; BONE MARROW; COMPRESSIVE STRENGTH; FEMALE; FEMUR; LETHAL DOSE 50; MATERIALS TESTING; METHACRYLATES; METHYLMETHACRYLATES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STRESS, MECHANICAL; TEMPERATURE;

EID: 52449097791     PISSN: 13428810     EISSN: 13428810     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Lewis G. Properties of acrylic bone cement: State of the art review. J Biomed Mater Res: Appl Biomater 1997;38B:155-182.
2. Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg 1960;42B:28-30.
3. Amar AP, Larsen DW, Esnaashari N, et al. Percutaneous transpedicular polymethylmethacrylate vertebroplasty for the treatment of spinal compression fractures. Neurosurgery 2001;49:1105-1115.
4. Dunne NJ, Orr JF. Curing characteristics of acrylic bone cement. J Mater Sci: Mater Med 2002;13:17-22.
5. Duncan JA. Intra-operative collapse or death related to the use of acrylic cement in hip surgery. Anaesthesia 1989;44:149-153.
6. Byrick RJ. Cement implantation syndrome: a time limited embolic phenomenon. Can J Anaesth 1997;44:107-111.
7. Pharmaceutical and Medical Safety Bureau, Ministry of Health, Labour and Welfare (Japan). Serious health risk related to the use of bone cement (in Japanese). Pharmaceuticals and medical devices safety information, 2005;216:2-10.
8. Schlegel UJ, Sturm M, Ewerbeck V, et al. Efficacy of vacuum bone cement mixing systems in reducing methylmethacrylate fume exposure Comparison of 7 different mixing devices and handmixing. Acta Orthop Scand 2004;75:559-566.
9. Jensen JS, Trap B, Skydsgaard K. Delayed contact hypersensitivity and surgical glove penetration with acrylic bone cements. Acta Orthop Scand 1991;62:24-28.
10. Revell P, George M, Braden M, et al. Experimental studies of the biological response to a new bone cement. Part I Toxicity of n-butylmethacrylate monomer compared with methylmethacrylate monomer. J Mater Sci: Mater Med 1992;3:84-87.
11. Hasenwinkel JM, Lautenschlager EP, Wixson RL, et al. A novel high-viscosity, two-solution acrylic bone cement: Effect of chemical composition on properties. J Biomed Mater Res 1999;47:36-45.
12. Shinzato S, Kobayashi M, Mousa WF, et al. Bioactive polymethyl methacrylate-based bone cement: Comparison of glass beads, apatite- and wollastonite-containing glass ceramic, and hydroxyapatite fillers on mechanical and biological properties. J Biomed Mater Res, 2000;51:258-272.
13. OECD guideline for testing of chemicals. Acute Oral Toxicity. Up-and-Down Procedure (2001).
14. International standards, ISO 5833. Implants for surgery -Acrylic resin cements. International Organization for Standardization; 1992.
15. Parvizi J, Holiday AD, Ereth MH, et al. Sudden death during primary hip arthroplasty. Clin Orthop Relat Res 1999;369:39-48.
16. Fallon KM, Fuller JG, Morley-Forster P. Fat embolization and fatal cardiac arrest during hip arthroplasty with methylmethacrylate. Canad J Anesthesia 2001 ;48:626-629.
17. Vasconcelos C, Gailloud P, Martin JB, et al. Interventional neuroradiology transient arterial hypotension induced by polymethylmethacrylate injection during percutaneous vertebroplasty. J Vasc Interv Radiol 2001;12:1001-1002.
18. Mir GN, Lawrence WH, Autian J. Toxicological and pharmacological actions of methacrylate monomers. I. Effects on isolated, perfused rabbit heart. J Pharm Sci 1973;62:778-782.
19. Chung CW, Giles AL. Sensitization potentials of methyl, ethyl, and n-butyl methacrylates and mutual cross-sensitivity in guinea pigs. J Investig Dermatl 1977;68:187-190.
20. Karlsson J, Wendling W, Chen D, et al. Methylmethacrylate monomer produces direct relaxation of vascular smooth muscle in vitro. Acta Anaesthesiol Scand 1995;39:685-689.
21. Motobe T, Hashiguchi T, Uchimura T, et al. Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. Shock 2004;21:8-12.
22. Mir GN, Lawrence WH, Autian J. Toxicological and pharmacological actions of methacrylate monomers. III. Effects on respiratory and cardiovascular functions of anesthetized dogs. J Pharm Sci 1974;63:376-381.
23. Puska MA, Narhi TO, Aho AJ, et al. Flexural properties of crosslinked and oligomer-modified glass-fibre reinforced acrylic bone cement. J Mater Sci: Mater Med 2004;15:1037-1043.
24. Marrs B, Andrews R, Rantell T, et al. Augmentation of acrylic bone cement with multiwall carbon nanotubes. J Biomed Mater Res 2003;77A:269-276.
25. Kotha SP, Li C, Schmid SR, et al. Fracture toughness of steel-fiber-reinforced bone cement. J Biomed Mater Res 2004;70A:514-521.
26. Weightman B. Freeman MAR, Revell PA, et al.The mechanical properties of cement and loosening of the femoral component of hip replacements. J Bone Joint Surg 1987;69B:558-564.
27. Carrodeguas RG, Lasa BV, Del Barrio JSR. Injectable acrylic bone cements for vertebroplasty with improved properties. J Biomed Mater Res: Appl Biomater 2004;68B:94-104.