Stimulation of contractions in human myometrium by serotonin is unmasked by smooth muscle relaxants

Reproductive Sciences

Volumn 15, Issue 7, 2008, Pages 727-734

  Cordeaux, Yolande ^a   Missfelder Lobos, Hannah ^a   Charnock Jones, D Stephen ^a   Smith, Gordon C S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Human myometrium; Serotonin; Smooth muscle relaxants; Uterine contractions

Indexed keywords

ADENYLATE CYCLASE; DIAZOXIDE; FORSKOLIN; SEROTONIN;

ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; MYOMETRIUM; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; UTERINE ATONY;

FEMALE; FORSKOLIN; HUMANS; MUSCLE, SMOOTH; MYOMETRIUM; PARASYMPATHOLYTICS; PREGNANCY; SEROTONIN; UTERINE CONTRACTION;

EID: 52449084168     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719108317582     Document Type: Article

References (31)

1. Hoyer D., Hannon JP, Martin GR Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav. 2002 ; 71: 533-554.
2. Alexander SP, Mathie A., Peters JA Guide to receptors and channels, 2 nd edition. Br J Pharmacol. 2006 ; 147 (suppl 3). S1 - S168.
3. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology. 1999 ; 38: 1083-1152.
4. Kaumann AJ, Levy FO 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacol Ther. 2006 ; 111: 674-706.
5. De Ponti F. Pharmacology of serotonin: what a clinician should know. Gut. 2004 ; 53: 1520-1535.
6. Freyburger WA, Graham BE, Rapport MM, et al. The pharmacology of 5-hydroxytryptamine (serotonin). J Pharmacol Exp Ther. 1952 ; 105: 80-86.
7. Woolley DW A probable mechanism of action of serotonin. Proc Natl Acad Sci U S A. 1958 ; 44: 197-201.
8. Contractor SF, Jones JJ, Lee J., Morris NF The responses of the human myometrium to 5-hydroxytryptamine (5-HT) and oxytocin (syntocinon) and its monoamine oxidase (MAO) activity during gestation. J Physiol. 1968 ; 195: 16P - 17P.
9. Minosyan TY, Lu R., Eghbali M., Toro L., Stefani E. Increased 5-HT contractile response in late pregnant rat myometrium is associated with a higher density of 5-HT2A receptors. J Physiol. 2007 ; 581: 91-97.
10. Kelly CR, Sharif NA Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line. J Pharmacol Exp Ther. 2006 ; 317: 1254-1261.
11. Sweeney G., Templeton A., Clayton RA, et al. Contractile responses to sumatriptan in isolated bovine pulmonary artery rings: relationship to tone and cyclic nucleotide levels. J Cardiovasc Pharmacol. 1995 ; 26: 751-760.
12. Shaw AM, Bunton DC, Brown T., Irvine J., MacDonald A. Regulation of sensitivity to 5-hydroxytryptamine in pulmonary supernumerary but not conventional arteries by a 5-HT1D-like receptor. Eur J Pharmacol. 2000 ; 408: 69-80.
13. Bardou M., Cortijo J., Loustalot C., et al. Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium. Naunyn Schmiedebergs Arch Pharmacol. 1999 ; 360: 457-463.
14. Zawadzki W., Zieba D., Dejneka J. Changes in uterus myoelectrical activity under influence of serotonin in sheep sensitised and non-sensitised with stilboestrol. Electr J Pol Agric Univ Vet Med. 1999 ; 2: 1-8.
15. Cruz MA, Gonzalez C., Acevedo CG, Sepulveda WH, Rudolph MI Effects of histamine and serotonin on the contractility of isolated pregnant and non-pregnant human myometrium. Gynecol Obstet Invest. 1989 ; 28: 1-4.
16. Rudolph MI, Rojas IG, Penissi AB Uterine mast cells: a new hypothesis to understand how we are born. Biocell. 2004 ; 28: 1-11.
17. Garfield RE, Irani AM, Scwartz LB, Bytautiene E., Romero R. Structural and functional comparison of mast cells in the pregnant versus nonpregnant human uterus. Am J Obstet Gynecol. 2006 ; 194: 261-267.
18. Rudolph MI, Reinicke K., Cruz MA, Gallardo V., Gonzalez C., Bardisa L. Distribution of mast cells and the effect of their mediators on contractility in human myometrium. Br J Obstet Gynaecol. 1993 ; 100: 1125-1130.
19. Bytautiene E., Vedernikov YP, Saade GR, Romero R., Garfield RE Degranulation of uterine mast cell modifies contractility of isolated myometrium from pregnant women. Am J Obstet Gynecol. 2004 ; 191: 1705-1710.
20. Rudolph MI, Oviedo C., Vega E., et al. Oxytocin inhibits the uptake of serotonin into uterine mast cells. J Pharmacol Exp Ther. 1998 ; 287: 389-394.
21. Elovitz MA, Ascher-Landsberg J., Saunders T., Phillippe M. The mechanisms underlying the stimulatory effects of thrombin on myometrial smooth muscle. Am J Gynecol. 2000 ; 183: 674-681.
22. Adebiyi A., Adaikan GP, Prasad RN Oxytocic activity of thrombin: modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists. J Perinat Med. 2004 ; 32: 126-131.
23. Hollingsworth M., Edwards D., Miller M. Ergometrine-a partial agonist at 5-HT receptors in the uterus isolated from oestrogen-primed rat. Eur J Pharm. 1988 ; 158: 79-84.
24. McLaughlin AD The action of ergometrine on the isolated human uterus. J Pharm Exp Ther. 1938 ; 64: 243-249.
25. Roberts RE, Kendall DA, Wilson VG A study of NPY-mediated contractions of the porcine ear artery. Br J Pharm. 1999 ; 127: 284-290.
26. Roberts RE, Tomlinson AE, Kendall DA, Wilson VG α2-Adrenoceptor- mediated contractions of the porcine isolated ear artery: evidence for a cyclic AMP-dependent and a cyclic-AMP-independent mechanism. Br J Pharm. 1998 ; 124: 1107-1114.
27. Komalavilas P., Mehta S., Wingard CJ, et al. PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways. J Appl Physiol. 2001 ; 91: 1819-1827.
28. Leroy MJ, Lugnier C., Merezek J., et al. Isolation and characterization of the rolipram-sensitive cyclic AMP-specific phosphodiesterase (type IV PDE) in human term myometrium. Cell Signal. 1994 ; 6: 405-412.
29. Shum JKS, Melendez JA, Jeffrey JJ Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C and ERK1/2 in rat uterine smooth muscle cells. J Biol Chem. 2002 ; 277: 42830-42840.
30. Kordowska J., Huang R., Wang CL Phosphorylation of caldesmon during smooth muscle contraction and cell migration or proliferation. J Biomed Sci. 2006 ; 13: 159-172.
31. CordeauxY., Missfelder-Lobos H., Charnock-Jones DS, Smith GCS. Functional and molecular characterization of 5-HT2 serotonin receptors in myometrium from pregnant women at term. Reprod Sci. 2007 ; 14 (suppl): 229A.